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Lymphoproliferative Disorders |
1 Nuclear Medicine Department, University Hospital, Nantes
2 Histopathology Department, University Hospital, Nantes
3 Statistics Department, René Gauducheau Cancer Centre, Nantes
4 Radiology Department, University Hospital, Nantes
5 Hematology Department, University Hospital, Nantes, France
Correspondence: Steven Le Gouill, Haematology Department, University Hospital, Place Alexis Ricordeau, 44093 Nantes cedex 1, France. Phone: international +33.02.40083263. Fax: international +33.02.40083250. E-mail: steven.legouill{at}chu-nantes.fr
Positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) has been successfully evaluated in the management of non-Hodgkins lymphoma (NHL).1–3 Histological transformation (HT) of indolent lymphoma is a dramatic event that occurs in 5–10% of the patients and carries a dismal prognosis.4,5 Previous studies prove that indolent lymphoma entities show a lower FDG uptake when compared with aggressive lymphomas.6–8 We therefore postulated that FDG-PET/CT identifies aggressive transformation sites and can guide biopsies.
Key words: FDG-PET/CT, lymphoma, biopsy, histological transformation.
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