Haematologica
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Haematologica, Vol 93, Issue 3, 471-472 doi:10.3324/haematol.12013
Copyright © 2008 by Ferrata Storti Foundation
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Lymphoproliferative Disorders

Investigation of FDG-PET/CT imaging to guide biopsies in the detection of histological transformation of indolent lymphoma

Caroline Bodet-Milin1, Françoise Kraeber-Bodéré1, Philippe Moreau2, Loïc Campion3, Benoît Dupas4, Steven Le Gouill5,

1 Nuclear Medicine Department, University Hospital, Nantes
2 Histopathology Department, University Hospital, Nantes
3 Statistics Department, René Gauducheau Cancer Centre, Nantes
4 Radiology Department, University Hospital, Nantes
5 Hematology Department, University Hospital, Nantes, France

Correspondence: Steven Le Gouill, Haematology Department, University Hospital, Place Alexis Ricordeau, 44093 Nantes cedex 1, France. Phone: international +33.02.40083263. Fax: international +33.02.40083250. E-mail: steven.legouill{at}chu-nantes.fr

Positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) has been successfully evaluated in the management of non-Hodgkin’s lymphoma (NHL).1–3 Histological transformation (HT) of indolent lymphoma is a dramatic event that occurs in 5–10% of the patients and carries a dismal prognosis.4,5 Previous studies prove that indolent lymphoma entities show a lower FDG uptake when compared with aggressive lymphomas.6–8 We therefore postulated that FDG-PET/CT identifies aggressive transformation sites and can guide biopsies.

Key words: FDG-PET/CT, lymphoma, biopsy, histological transformation.







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