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Thrombophilia as a predictor of persistent residual vein thrombosis

Department of Medical and Surgical Sciences, Clinica Medica II
¹ Department of Pediatrics, Unit of Epidemiology and Community Medicine, University of Padua, Italy

Correspondence: Paolo Prandoni, Dipartimento di Scienze Mediche e Chirurgiche, Clinica Medica II, Università di Padova, via Ospedale Civile 105, 35128 Padua, Italy. E-mail: paoloprandoni{at}tin.it

To compare the probability of leg vein recanalization between carriers and non-carriers of thrombophilia after an episode of deep vein thrombosis (DVT) of the lower extremities, we reviewed the clinical records of 472 patients with proximal DVT who were diagnosed with thrombophilia, and had long-term ultrasound scanning. One hundred and thirty-seven patients (29.0%) were carriers of thrombophilia. After adjusting for age, sex, DVT localization and modality of presentation, the hazard ratio of vein recanalization in thrombophilic compared with non-thrombophilic patients was 0.49 (95% CI, 0.38 to 0.63). These findings suggest that thrombophilia is an independent predictor of persistent residual vein thrombosis.