Published online 6 March 2008
Haematologica, Vol 93, Issue 4, 619-622 doi:10.3324/haematol.11867
Copyright © 2008 by Ferrata Storti Foundation
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Multiple Myeloma

Hepatocyte growth factor promotes migration of human myeloma cells

Randi Utne Holt1,2, Unn-Merete Fagerli1,3, Vadim Baykov1, Torstein Baade Rø1, Håkon Hov1, Anders Waage1,4, Anders Sundan1, Magne Børset1,5

1 Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim;
2 Faculty of Technology, Sør Trøndelag University College, Trondheim;
3 Departments of Oncology;
4 Hematology;
5 Immunology and Transfusion Medicine, St. Olavs Hospital, Trondheim, Norway

Correspondence: Randi Utne Holt, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, N-7489 Trondheim, Norway. Phone: international +47.73550309. Fax: international +47.73598801. E-mail:randi.u.holt{at}ntnu.no

Multiple myeloma is characterized by the accumulation and dissemination of malignant plasma cells in the bone marrow. Cell migration is thought to be important for these events. We studied migration in a Transwell two-chamber assay and tested the motogenic effect of various cytokines. In addition to insulin-like growth factor-1 and stromal cell-derived growth factor-1{alpha}, previously known as chemoattractants for myeloma cells, we identified hepatocyte growth factor as a potent attractant for myeloma cells. Hepatocyte growth factor-mediated migration was dependent on phosphatidylinositol-3-kinase, involved the MAPK/Erk signaling cascade and VLA-4 integrins, but did not involve Akt, mTOR or G proteins.

Key words: myeloma, cell migration, hepatocyte growth factor, stromal cell-derived growth factor-1.




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