Published online 6 March 2008
Haematologica, Vol 93, Issue 4, 623-626 doi:10.3324/haematol.12005
Copyright © 2008 by Ferrata Storti Foundation
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Multiple Myeloma

Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics

Karin Bink1, Eugenia Haralambieva2, Marcus Kremer3, German Ott4, Christine Beham-Schmid5, Laurence de Leval6, Suat Cheng Peh7, Hubert R. Laeng8, Uta Jütting9, Peter Hutzler1, Leticia Quintanilla-Martinez1, Falko Fend3

1 Institutes of Pathology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Oberschleissheim;
2 University of Würzburg;
3 Technical University of Munich;
4 Robert Bosch Hospital, Stuttgart, Germany;
5 University of Graz, Austria;
6 University of Liège, Belgium;
7 University of Malaya, Malaysia;
8 Kantonsspital Aarau, Switzerland;
9 Institute of Biomathematics and Biometry, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Oberschleissheim, Germany

Correspondence: Falko Fend, M.D., Institute of Pathology, University Hospital Tuebingen, Eberhard-Karls-University, Liebermeisterstrasse 8, 72076 Tuebingen, Germany. E-mail:falko.fend{at}med.uni-tuebingen.de

Primary extramedullary plasmacytoma is an indolent neoplasm that infrequently converts to multiple myeloma. Since cytogenetic data on extramedullary plasmacytoma are lacking, we studied 38 cases of this type of neoplasm by fluorescence in situ hybridization. Fourteen cases (37%) contained IGH breaks, including six with a t(4;14) translocation. No translocations t(11;14), t(14;16), t(8;14), nor breaks involving MALT1, BCL6 or FOXP1 were found. Loss of 13q (40%), as well as chromosomal gains (82%) were common. There was no correlation between chromosomal alterations and clinical features or local relapse. Cytogenetically, extramedullary plasmacytoma and multiple mueloma are closely related. However, the distribution of IGH translocation partners, with the notable absence of t(11;14), is different. Key words: extramedullary plasmacytoma, multiple myeloma, cytogenetics, IGH translocation, fluorescence in situ hybridization.