Haematologica
HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
QUICK SEARCH:   [advanced]


     

Published online 27 May 2008
Haematologica, Vol 93, Issue 7, 1017-1024 doi:10.3324/haematol.12004
Copyright © 2008 by Ferrata Storti Foundation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lo-Coco, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lo-Coco, F.
Related Collections
Right arrowRelated Article

Acute Myeloid Leukemia

Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia

Francesco Lo-Coco, Antonio Cuneo, Fabrizio Pane, Daniela Cilloni, Daniela Diverio, Marco Mancini, Nicoletta Testoni, Antonella Bardi, Barbara Izzo, Niccolò Bolli, Roberta La Starza, Paola Fazi, Simona Iacobelli, Alfonso Piciocchi, Marco Vignetti, Sergio Amadori, Franco Mandelli, Pier Giuseppe Pelicci, Cristina Mecucci, Brunangelo Falini, Giuseppe Saglio, for the Acute Leukemia Working Party of the GIMEMA group

Acute Leukemia Working Party of the GIMEMA group

Correspondence: Francesco Lo-Coco, Department of Biopathology, University Tor Vergata, via Montpellier 1, 00161 Rome, Italy, E-mail:francesco.lo.coco{at}uniroma2.it

Background: Recent advances in genetic characterization of acute myeloid leukemia indicate that combined cytogenetic and molecular analyses provide better definition of prognostic groups. The aim of this study was to verify this prospectively in a large group of patients.

Design and Methods: Genetic characterization was prospectively carried out in 397 patients with acute myeloid leukemia (median age, 46 years) receiving uniform treatment according to the LAM99P protocol of the Italian GIMEMA group. The impact of genetic markers on response to therapy and outcome was assessed by univariate and multivariate analyses.

Results: For induction response, conventional karyotyping identified three groups with complete remission rates of 92%, 67% and 39% (p<0.0001). Complete remission rates in NPM1 mutated (NPM1+) and wild-type (NPM1-) groups were 76% and 60%, respectively, for the whole population and 81% and 61% in the group with normal karyotype (p<0.001 and p=0.026, respectively). Multivariate analysis indicated that low risk karyotype and NPM1+ were independent factors favorably affecting complete remission. Multivariate analysis of overall and disease-free survival among 269 patients who achieved complete remission showed a significant impact of karyotype on both estimates and of FLT3 status on disease free-survival (FLT3-ITD vs. FLT3 wild-type, p=0.0001). NPM1 status did not significantly influence disease free-survival in either the whole population or in the patients with a normal karyotype in this series, probably due to the low number of cases analyzed.

Conclusions: These results reiterate the prognostic relevance of combining cytogenetic and mutational analysis in the diagnostic work up of patients with acute myeloid leukemia.


Related Article

Molecular characterization of acute myeloid leukemia
Konstanze Döhner, Hartmut Döhner
Haematologica 2008 93: 976-982. [Full Text] [PDF]





HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
Copyright © 2008 by the Ferrata Storti Foundation.