Published online 4 July 2008
Haematologica, Vol 93, Issue 9, 1372-1375 doi:10.3324/haematol.12915
Copyright © 2008 by Ferrata Storti Foundation
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Erythropoiesis

Variation of hemoglobin levels in normal Italian populations from genetic isolates

Cinzia Sala1, Marina Ciullo3, Carmela Lanzara4, Teresa Nutile3, Silvia Bione1, Roberto Massacane5, Pio d’Adamo4, Paolo Gasparini4, Daniela Toniolo1, Clara Camaschella1,2

1 DIBIT-San Raffaele Scientific Institute
2 Vita-Salute San Raffaele University, Milan
3 Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" CNR Naples
4 Genetica Medica, Dipartimento di Scienze della Riproduzione e dello Sviluppo, IRCCS-Burlo Garofolo, Università di Trieste
5 Laboratorio ASL 22 Novi Ligure, Italy

Correspondence: Clara Camaschella, MD, Università Vita-Salute San Raffaele, via Olgettina, 60, 20132 Milan, Italy. E-mail:camaschella.clara{at}hsr.it

Normal hemoglobin levels vary greatly according to genetic and acquired factors. As a consequence there is no general agreement on the definition of anemia in terms of hemoglobin levels. Here we compare the hemoglobin levels of subjects recruited from normal genetically isolated Italian populations whose medical history, life style habits and results of laboratory tests are available. After the exclusion of pathological samples we analyzed the hemoglobin levels of 3,849 subjects (1,661 males and 2,188 females) and evaluated the hemoglobin heritability. Normal subjects of different age groups from a northern Italian isolate have significantly higher hemoglobin levels when compared to matched subjects of southern Italian isolates. The estimated heritability of hemoglobin levels ranges from 0.34 to 0.42 in the different isolates. Our study provides a dataset of hemoglobin levels for normal subjects of different geographical origin and indicate that hemoglobin levels are substantially influenced by heritable components.

Key words: hemoglobin, anemia, genetic isolates.




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