4th Palermo Conference on INNOVATIVE THERAPIES FOR LYMPHOID MALIGNANCIES
Haematologica, Vol 94, Issue 10, 1453-1455 doi:10.3324/haematol.2009.008508
Copyright © 2009 by Ferrata Storti Foundation
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Myelodysplastic Syndromes

Low RPS14 expression is common in myelodysplastic syndromes without 5q- aberration and defines a subgroup of patients with prolonged survival

Akos Czibere, Ingmar Bruns, Bärbel Junge, Raminder Singh, Guido Kobbe, Rainer Haas, Ulrich Germing

Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Duesseldorf, Germany

Correspondence: Akos Czibere, MD, Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Duesseldorf Moorenstraße 5, 40225 Duesseldorf, Germany. E-Mail address:Akos.Czibere{at}med.uni-duesseldorf.de

To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (INT-1) score according to the international prognostic scoring system and low RPS14 expression had a superior median overall survival of not reached versus 25 months compared to INT-1 patients with high RPS14 expression (p=0.0249). Using multivariate analysis, the RPS14 expression status was confirmed as an independent predictor for survival in INT-1 patients.

Key words: low RPS14, myelodysplastic syndromes, prolonged survival, 5q- aberration.


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N. Galili, S. A. Qasim, and A. Raza
Defective ribosome biogenesis in myelodysplastic syndromes
Haematologica, October 1, 2009; 94(10): 1336 - 1338.
[Full Text] [PDF]