Haematologica, Vol 94, Issue 11, 1563-1568 doi:10.3324/haematol.2009.008474
Copyright © 2009 by Ferrata Storti Foundation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Google Scholar
Right arrow Articles by Dictor, M.
Right arrow Articles by Borrebaeck, C.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dictor, M.
Right arrow Articles by Borrebaeck, C.
Related Collections
Right arrowRelated Article

Malignant Lymphomas

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt’s lymphoma

Michael Dictor1, Sara Ek3, Maria Sundberg1, Janina Warenholt1, Czabafy György1, Sandra Sernbo3, Elin Gustavsson3, Waleed Abu-Alsoud2,*, Torkel Wadström2, Carl Borrebaeck3

1 Departments of Pathology
2 Medical Microbiology, Lund University Hospital
3 Department of Immunotechnology, CREATE Health, BioMedical Center (BMC) D13, Lund University, Lund, Sweden

Correspondence: Michael Dictor, Department of Pathology, Lund University Hospital, Sölvegatan 25, 22185 Lund, Sweden. E-mail:michael.dictor{at}med.lu.se

Background: We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1.

Design and Methods: On hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed.

Results: Nuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt’s lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were negative for SOX11, as were all cases of intermediate Burkitt’s lymphomas/diffuse large B-cell lymphoma, myeloma, Hodgkin’s lymphomas and mature T-cell and NK/T-cell lymphomas.

Conclusions: In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt’s lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia.

Key words: lymphoid, SOX11 transcription factors, lymphoblastic neoplasms, mantle cell lymphoma, Burkitt’s lymphoma.


Related Article

Mantle cell lymphoma
Stefano A. Pileri, Brunangelo Falini
Haematologica 2009 94: 1488-1492. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 haematolHome page
S. A. Pileri and B. Falini
Mantle cell lymphoma
Haematologica, November 1, 2009; 94(11): 1488 - 1492.
[Full Text] [PDF]