Published online 14 January 2009
Haematologica, Vol 94, Issue 2, 264-268 doi:10.3324/haematol.13755
Copyright © 2009 by Ferrata Storti Foundation
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Myelodysplastic Syndromes

Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellular myelodysplastic syndromes and aplastic anemia: recommendations for a standardized approach

John M. Bennett1, Attilio Orazi2

1 James P. Wilmot Cancer Center, University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, Rochester, NY
2 Weill Medical College of Cornell University, Department of Pathology and Laboratory Medicine, New York, NY, USA

Correspondence: John M. Bennett, M.D., James P. Wilmot Cancer Center, University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, 601 Elmwood Avenue, Box 626, Rochester, NY 14642 USA., E-mail:John_Bennett{at}urmc.rochester.edu

Members of the French-American-British Cooperative Leukemia Working Group met to review cases of aplastic anemia, hypocellular myelodysplastic syndrome and hypocellular acute myeloid leukemia. Criteria were proposed and modified following three workshops. Additional input was obtained from another hematopathologist with a special interest in bone marrow histology and immunohistochemistry. Guidelines were recommended based on the workshop results as well as additional studies including selective immunohistochemistry, flow cytometry and cytogenetics.

Key words: hypocellular myelodysplasia, hypocellular myeloid leukemia, abnormal localization of immature precursors, aplastic anemia.




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Flow cytometry immunophenotyping for diagnosis of myelodysplastic syndrome
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