4th Palermo Conference on INNOVATIVE THERAPIES FOR LYMPHOID MALIGNANCIES
Published online 19 February 2009
Haematologica, Vol 94, Issue 4, 536-541 doi:10.3324/haematol.2008.002741
Copyright © 2009 by Ferrata Storti Foundation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Querol, S.
Right arrow Articles by Madrigal, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Querol, S.
Right arrow Articles by Madrigal, J. A.
Related Collections
Right arrowRelated Article

Stem Cell Transplantation

Cord blood stem cells for hematopoietic stem cell transplantation in the UK: how big should the bank be?

Sergio Querol1,2,3, Ghulam J. Mufti3, Steven G.E. Marsh1,2, Antonio Pagliuca3, Ann-Margaret Little1,2, Bronwen E. Shaw1,2,4, Robert Jeffery1, Joan Garcia5, John M. Goldman1, J. Alejandro Madrigal1,2

1 Anthony Nolan Research Institute, Royal Free Hospital, London, UK
2 Department of Haematology, UCL Cancer Institute, Royal Free Campus, London, UK
3 Department of Haematology, Kings College Hospital and Kings College, London, UK
4 Royal Marsden Hospital, Sutton, Surrey, UK
5 Programa de Sang de Cordó, Banc de Sang i Teixits, Barcelona, Spain

Correspondence: J. Alejandro Madrigal, Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London NW3 2QG, UK. E-mail:a.madrigal{at}medsch.ucl.ac.uk

Background: A stored cord blood donation may be a valuable source of hemopoietic stem cells for allogeneic transplantation when a matched sibling donor is not available. We carried out a study to define the optimal size of a national cord blood bank for the UK.

Design and Methods: We calculated the actual numbers of possible donors and the chance of finding at least one donor for 2,000 unselected and for 722 non-North Western European patients for whom searches had been initiated as a function of three levels of HLA matching (4, 5 and 6 out of 6 alleles by HLA-A, -B low and -DRB1 high resolution HLA typing) according to various donor bank sizes.

Results: With a bank size of 50,000, 80% of patients will have at least one donor unit available at the 5 out of 6 HLA allele match level (median 9 donors per patient), and 98% will have at least one donor at the 4 out of 6 allele match level (median 261). Doubling the size of the bank yields at least one donor for only an additional 6% of patients at the 5 of 6 allele match level. Moreover, for non-North Western European patients a 50,000 unit bank provides a donor for 50% at the 5 allele match level, and for 96% at the 4 allele match level.

Conclusions: A bank containing 50,000 units is optimal for the UK and larger banks would only marginally increase the chance of finding suitable units.

Key words: cord blood, banking, stem cell transplantation.


Related Article

Cord blood transplantation: state of the art
Eliane Gluckman, Vanderson Rocha
Haematologica 2009 94: 451-454. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 BloodHome page
S. Querol
A case of mistaken identity
Blood, August 20, 2009; 114(8): 1459 - 1460.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
E. Gluckman and V. Rocha
Cord blood transplantation: state of the art
Haematologica, April 1, 2009; 94(4): 451 - 454.
[Full Text] [PDF]