4th Palermo Conference on INNOVATIVE THERAPIES FOR LYMPHOID MALIGNANCIES
Published online 18 April 2009
Haematologica, Vol 94, Issue 6, 857-860 doi:10.3324/haematol.2008.000034
Copyright © 2009 by Ferrata Storti Foundation
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Brief Reports

Angiotensin-(1–7) stimulates hematopoietic progenitor cells in vitro and in vivo

Silvia Heringer-Walther1, Klaus Eckert2, Sarah-Mai Schumacher3, Lutz Uharek4, Annika Wulf-Goldenberg2, Florian Gembardt5,6, Iduna Fichtner2, Heinz-Peter Schultheiss3, Kathy Rodgers7, Thomas Walther3,5

1 Department of Gynaecology, University of Leipzig, Germany
2 Max-Delbrück-Center, Berlin-Buch, Germany
3 Department of Cardiology, Charité, Campus Benjamin Franklin, Berlin, Germany
4 Department of Haematology, Charité, Campus Benjamin Franklin Berlin, Germany
5 Department of Pharmacology, Erasmus Medical Centre, Rotterdam, The Netherlands
6 Centre for Biomedical Research, Hull York Medical School, University of Hull, UK
7 Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA

Correspondence: Thomas Walther, Centre for Biomedical Research, Hull York Medical School, University of Hull, Hull, HU6 7RX, United Kingdom. E-mail:thomas.walther{at}hyms.ac.uk

ABSTRACT

Effects of angiotensin (Ang)-(1–7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1–7) to stimulate proliferation of human CD34+ and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1–7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+ and CD34+ cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1–7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.

Key words: angiotensin, CD34, hematopoietic stem cell.


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