Published online 16 July 2009
Haematologica, Vol 94, Issue 8, 1109-1123 doi:10.3324/haematol.2009.005983
Copyright © 2009 by Ferrata Storti Foundation
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Acute Leukemia

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

Richard J. Bende, Febe van Maldegem, Carel J.M. van Noesel

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Correspondence: Carel J.M. van Noesel, Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. E-mail:c.j.vannoesel{at}amc.uva.nl

Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) ‘potential’ mouse models for MZBCL.

Key words: B-cell non-Hodgkin’s lymphoma, extranodal marginal zone B-cell lymphoma, immunoglobulin, B-cell antigen receptor, inflammation, lymphoid tissue neogenesis.