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Anemia management in patients on peritoneal dialysis: efficacy and safety of epoetin

New York Hospital, Queens, Cornell University Medical Center, New York, NY, USA

Correspondence: Bruce S. Spinowitz, M.D. FACP, Associate Director, Nephrology, Associate Chairman, Medicine, New York Hospital, Queens, Clinical Professor of Medicine, Cornell University Medical Center, New York, NY, USA. E-mail: bss9001{at}nyp.org

ABSTRACT

In a one-year, multicenter, open-label, uncontrolled trial, epoetin was given subcutaneously, 1–3-times weekly to peritoneal dialysis patients who had previously received an epoetin. Dose was adjusted to maintain hemoglobin at 1.00–1.20 g/L. The primary endpoint was mean hemoglobin over weeks 12–24. Safety was assessed. Mean±SD baseline hemoglobin was 1.12±0.09 g/L. Hemoglobin over weeks 12–24 was 1.16±0.11 g/L. Adverse events were those expected in this patient population. No life-threatening adverse events occurred. Subcutaneous epoetin was effective and well tolerated for the treatment of anemia in peritoneal dialysis patients.

Key words: anemia, peritoneal dialysis, epoetin.