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Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem- and progenitor- cell mobilization

¹ Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden
² Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Correspondence: Melissa van Pel, PhD, Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, E3-Q, P.O. box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.van_pel{at}lumc.nl

ABSTRACT

CD97 is broadly expressed on hematopoietic cells and is involved in neutrophil migration. Since neutrophils are key regulators in HSC/HPC mobilization, we studied a possible role for CD97 in interleukin-8 and granulocyte-colony stimulating factor-induced HSC/HPC mobilization. Mobilization was absent in mice receiving CD97 mAb followed by interleukin-8, while granulocyte-colony stimulating factor-induced mobilization remained unaltered following anti-CD97 administration. Furthermore, combined administration of CD97 mAb and IL-8 induced a significant reduction in the neutrophilic compartment. We hypothesize that the absence of interleukin-8-induced HSC/HPC mobilization after CD97 mAb administration is due to its effect on neutrophil function.

Key words: stem cell mobilization, CD97, IL-8, granulocyte-colony stimulating factor, animal models.