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Clinical and demographic characteristics of Epstein-Barr virus-associated childhood Burkitt’s lymphoma in Southeastern Brazil: epidemiological insights from an intermediate risk region

¹ Bone Marrow Transplantation Centre (CEMO)
² Hematology Service
³ Genetics Division, Instituto Nacional de Câncer (INCA)
⁴ Genetics Department, Universidade Federal do Rio de Janeiro (HNS), Rio de Janeiro, RJ, Brazil

Correspondence: Rocio Hassan, PhD, Instituto Nacional de Câncer, INCA-Bone Marrow Transplantation Centre (CEMO). Praça da Cruz Vermelha 23, 6th floor, 20230-130, Rio de Janeiro, RJ, Brazil. E-mail: biomol{at}inca.gov.br

ABSTRACT

We studied a group of 54 children with Burkitt’s lymphoma from Southeastern Brazil, where epidemiological status of Burkitt’s lymphoma is poorly understood. Epstein-Barr virus association showed an intermediate frequency (~60%) between endemic and sporadic subtypes. Median age was five years. Epstein-Barr virus infection was significantly associated to low age (Epstein-Barr virus⁺ four years vs. Epstein-Barr virus^– eight years). Sex ratio (M:F) was 2:1, with a significantly higher number of males in old age classes. Young age at diagnosis and excess of males at older ages, as well as a causal relationship between low age, epstein-barr virus and Burkitt’s lymphoma risk, may characterize Burkitt’s lymphoma in Brazil.

Key words: Burkitt’s lymphoma, Epstein-Barr virus, clinico-demographic, Brazil.