Haematologica, Vol 92, Issue 7, 1007-1008 doi:10.3324/haematol.10883
Copyright © 2007 by Ferrata Storti Foundation
Traumatic vs. atraumatic 22 G needle for therapeutic and diagnostic lumbar puncture in the hematologic patient: a prospective clinical trial
Ronit Lavi*,,
Jacob M. Rowe°,
Irit Avivi°
* From the Department of Anesthesiology,
° Department of Hematology, Rambam Medical Center, and Rappaport Faculty of Medicine Technion-Israel Institute of Technology, Haifa, Israel
Correspondence: Ronit Lavi, M.D., Anesthesiology Department, Rambam Medical Center, P.O.B. 9602, Haifa 31096, Israel. Phone: international +972.4.8542487. Fax: international +972.4.8542961. E-mail: lavironit{at}hotmail.com
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ABSTRACT
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We investigated the impact of needle type on post lumbar puncture headache (PLPH) in hematologic patients undergoing LP. We prospectively compared traumatic (TN) vs. atraumatic 22G needles. Twenty-seven patients underwent 48 LPs, 22 with chemotherapy injection. PLPH occurred almost exclusively with TN (4% vs. 30% p=0.02), irrespective of chemotherapy injection.
Key words: lumbar puncture, intrathecal chemotherapy, post lumbar puncture headache, traumatic needle, atraumatic needle.
Diagnostic lumbar puncture with or without intrathecal chemotherapy injection is often required in hematologic patients, particularly in patients diagnosed with high or intermediate grade lymphoma and acute lymphoblastic leukemia who are at high risk of CNS disease. These patients often have between 4–8 intrathecal methotraxte (MTX) injections from 8 days to a few weeks apart. Unfortunately, they often develop post lumbar puncture headache (PLPH), causing a delay, or even withdrawal of scheduled intrathecal MTX therapy.
PLPH is defined as a headache appearing within 12 days after LP (usually within 24–48 hours). It is exacerbated by standing and passes when the patient lies down. Treatment includes bed rest, analgesics, increased fluid intake (especially caffeine-containing beverages) and epidural blood patch.1,2,3 PLPH is more frequent in younger women with a low body mass index and in patients who have previously experienced PLPH.4 Technical factors affecting PLPH include patient’s position during procedure, bevel insertion of the needle in parallel to the patient’s axis, and reinsertion of a stylet before needle withdrawal.5,6 An atraumatic needle (ATN) has a blunt tip that separates the dural fibers instead of tearing them thus enabling their rapid closure. This potentially results in a lower incidence of PLPH compared with that observed with a traumatic needle (TN).5–8
We conducted a prospective randomized trial, comparing the incidence and severity of PLPH following diagnostic or therapeutic LP, using a TN versus an ATN 22G needle. The study was approved by the local IRB and informed consent was obtained from all patients. All hematologic patients, 18 years or older, that were scheduled for a diagnostic or therapeutic LP between July and December 2004 as part of their clinical management were included. Exclusion criteria were platelet count <80x109/L, evidence of increased intracranial pressure in fundoscopy and/or brain CT scan, and a previous LP, performed during the preceding week. Patients were randomly assigned according to identification number to undergo LP with a standard TN (Quincke, traumatic, 22 Gauge, 90 mm; TSK, JAPAN) versus an ATN (Whitacre, 22 Gauge, 0.70 mm, 103 mm, Polymedic, E.C, JAPAN). The same physician performed all LPs using the same technique with patients lying on their side and receiving local anesthesia. Introducer needle or traumatic needle bevel were directed parallel to the patient’s axis with stylets reinserted before needle withdrawal. Patients were required to lie down for an hour after LP. Patients were not aware of the needle type being used. Data collection included demographics, past medical history, indication for LP, procedure-related parameters and complications was obtained from questionnaires carried out by a blinded physician on days 2 and 7 post LP. PLPH was defined according to standard criteria.9 Twenty-seven patients (lymphoma 14; leukemia 13) underwent 48 LPs; 25 with an ATN and 23 with a TN. Patient characteristics, technique parameters and complications are presented in Table 1. Seventeen patients (63%) had a single LP, whereas 10 required repeated LPs (2–4), performed from a week to several weeks apart. All LPs, irrespective of the needle type being used, provided a sufficient amount of CSF for all tests required and allowed an intrathecal injection of chemotherapy to be given.
The incidence of PLPH following all LPs was higher with TN compared with an ATN: 7/23 vs. 1/25, (p=0.02). After adjustment to other covariates (age, and positive CSF results) that showed a trend in the univariate analysis (p<0.2), needle type remained an important predictor of PLPH (p=0.01). Only one episode resulted in a significant limitation of daily activities (VAS scale=4.8 range 2–10) and resolved within 12–48 hours (median 36 hours) after being treated with analgesics and increased fluid intake. Ten patients required 22 therapeutic LPs with intrathecal MTX alone (n=8) or in combination with cytarabine and steroids (n=14). Twelve of these LPs were performed with a TN and 10 with an ATN. All PLPH episodes occurred following a therapeutic LP with a TN (5/12, vs. none following a therapeutic LP with an ATN) (Figure 1). A therapeutic and diagnostic LP through a TN was associated with a higher risk of PLPH (5/12 and 2/11) whereas intrathecal chemotherapy through an ATN had the same low impact on PLPH risk as observed following a diagnostic LP through an ATN (0/10 vs. 1/15).
The use of ATN for diagnostic and therapeutic LPs in hematologic patients is safe and feasible. Furthermore, the results strongly support its superiority over the TN, providing a significant reduction in the incidence of PLPH and allowing the application of repeated therapeutic LPs according to treatment schedule.
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References
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