Haematologica: 100 (7)

June 30, 2015 ; 100 (7)

Editorials

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The search for the origin of factor VIII synthesis and its impact on therapeutic strategies for hemophilia A
Valder R. Arruda

Haematologica July 2015 100: 849-850; doi:10.3324/haematol.2015.129858
Disclosure
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Dangerous liaisons: cooperation between Pbx3, Meis1 and Hoxa9 in leukemia
Ross M. W. Thorne, Thomas A. Milne

Haematologica July 2015 100: 850-853; doi:10.3324/haematol.2015.129932
Disclosures and Contributions
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Rituximab maintenance therapy in diffuse large B-cell lymphoma: is XY the most important variable?
Matthew A Lunning, James O Armitage

Haematologica July 2015 100: 853-855; doi:10.3324/haematol.2015.129924
Disclosures and Contributions
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Personalized medicine in adult acute lymphoblastic leukemia
Dieter Hoelzer

Haematologica July 2015 100: 855-858; doi:10.3324/haematol.2015.127837
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Review Article

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Reduced intensity conditioning allogeneic hematopoietic cell transplantation for adult acute myeloid leukemia in complete remission - a review from the Acute Leukemia Working Party of the EBMT
Salyka Sengsayadeth, Bipin N. Savani, Didier Blaise, Florent Malard, Arnon Nagler, Mohamad Mohty

Haematologica July 2015 100: 859-869; doi:10.3324/haematol.2015.123331
Disclosures and Contributions

Articles

Red Cell Biology & Its Disorders

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Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease
Brian T. Kalish, Alessandro Matte, Immacolata Andolfo, Achille Iolascon, Olga Weinberg, Alessandra Ghigo, James Cimino, Angela Siciliano, Emilio Hirsch, Enrica Federti, Mark Puder, Carlo Brugnara, Lucia De Franceschi

Haematologica July 2015 100: 870-880; doi:10.3324/haematol.2015.124586
Kalish et al. Supplementary Appendix
Disclosures and Contributions

Coagulation & Its Disorders

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Extrahepatic sources of factor VIII potentially contribute to the coagulation cascade correcting the bleeding phenotype of mice with hemophilia A
Diego Zanolini, Simone Merlin, Maria Feola, Gabriella Ranaldo, Angela Amoruso, Gianluca Gaidano, Mauro Zaffaroni, Alessandro Ferrero, Sandra Brunelleschi, Guido Valente, Sanjeev Gupta, Maria Prat, Antonia Follenzi

Haematologica July 2015 100: 881-892; doi:10.3324/haematol.2014.123117
Zanolini et al. Graphical Abstract
Zanolini et al. Supplementary Appendix
Disclosures and Contributions

Myeloproliferative Disorders

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Analysis of phenotype and outcome in essential thrombocythemia with CALR or JAK2 mutations
Carla Al Assaf, Florence Van Obbergh, Johan Billiet, Els Lierman, Timothy Devos, Carlos Graux, Anne-Sophie Hervent, Jan Emmerechts, Thomas Tousseyn, Pascale De Paepe, Petros Papadopoulos, Lucienne Michaux, Peter Vandenberghe

Haematologica July 2015 100: 893-897; doi:10.3324/haematol.2014.118299
Al Assaf et al. Supplementary Appendix
Disclosures and Contributions
Disclosures and Contributions

Chronic Myeloid Leukemia

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A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy
Gautam Borthakur, Herve Dombret, Philippe Schafhausen, Tim Henrik Brummendorf, Nicolas Boissel, Elias Jabbour, Mariangela Mariani, Laura Capolongo, Patrizia Carpinelli, Cristina Davite, Hagop Kantarjian, Jorge E. Cortes

Haematologica July 2015 100: 898-904; doi:10.3324/haematol.2014.115279
Borthakur et al. Supplementary Appendix
Disclosures and Contributions

Acute Myeloid Leukemia

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Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia
Maria-Paz Garcia-Cuellar, Julia Steger, Elisa Füller, Katrin Hetzner, Robert K. Slany

Haematologica July 2015 100: 905-913; doi:10.3324/haematol.2015.124032
Garcia-Cuellar et al. Graphical Abstract
Garcia-Cuellar et al. Supplementary Appendix
Disclosures and Contributions
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Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice
Erwin M. Lee, Dean Yee, Samantha J. Busfield, Julie F. McManus, Nik Cummings, Gino Vairo, Andrew Wei, Hayley S. Ramshaw, Jason A. Powell, Angel F. Lopez, Ian D. Lewis, Martin N. McCall, Richard B. Lock

Haematologica July 2015 100: 914-926; doi:10.3324/haematol.2014.113092
Lee et al. Supplementary Appendix
Disclosures and Contributions
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Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia
Marina Konopleva, Peter F. Thall, Cecilia Arana Yi, Gautam Borthakur, Andrew Coveler, Carlos Bueso-Ramos, Juliana Benito, Sergej Konoplev, Yongchuan Gu, Farhad Ravandi, Elias Jabbour, Stefan Faderl, Deborah Thomas, Jorge Cortes, Tapan Kadia, Steven Kornblau, Naval Daver, Naveen Pemmaraju, Hoang Q. Nguyen, Jennie Feliu, Hongbo Lu, Caimiao Wei, William R. Wilson, Teresa J. Melink, John C. Gutheil, Michael Andreeff, Elihu H. Estey, Hagop Kantarjian

Haematologica July 2015 100: 927-934; doi:10.3324/haematol.2014.118455
Disclosures and Contributions
Konopleva et al. Supplementary Appendix

Acute Lymphoblastic Leukemia

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Minimal residual disease analysis by eight-color flow cytometry in relapsed childhood acute lymphoblastic leukemia
Leonid Karawajew, Michael Dworzak, Richard Ratei, Peter Rhein, Giuseppe Gaipa, Barbara Buldini, Giuseppe Basso, Ondrej Hrusak, Wolf-Dieter Ludwig, Günter Henze, Karl Seeger, Arend von Stackelberg, Ester Mejstrikova, Cornelia Eckert

Haematologica July 2015 100: 935-944; doi:10.3324/haematol.2014.116707
Karawajew et al. Supplementary Appendix
Disclosures and Contributions

Chronic Lymphocytic Leukemia

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Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B
Manoj K. Kashyap, Deepak Kumar, Reymundo Villa, James J. La Clair, Chris Benner, Roman Sasik, Harrison Jones, Emanuela M. Ghia, Laura Z. Rassenti, Thomas J. Kipps, Michael D. Burkart, Januario E. Castro

Haematologica July 2015 100: 945-954; doi:10.3324/haematol.2014.122069
Kashyap et al. Graphical Abstract
Kashyap et al. Supplementary Appendix
Disclosures and Contributions

Non-Hodgkin Lymphoma

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Rituximab maintenance for patients with aggressive B-cell lymphoma in first remission: results of the randomized NHL13 trial
Ulrich Jaeger, Marek Trneny, Helen Melzer, Michael Praxmarer, Weerasak Nawarawong, Dina Ben Yehuda, David Goldstein, Bilijana Mihaljevic, Osman Ilhan, Veronika Ballova, Michael Hedenus, Liang-Tsai Hsiao, Wing-Yan Au, Sonja Burgstaller, Gerhard Weidinger, Felix Keil, Christian Dittrich, Cathrin Skrabs, Anton Klingler, Andreas Chott, Michael A. Fridrik, Richard Greil

Haematologica July 2015 100: 955-963; doi:10.3324/haematol.2015.125344
Jaeger et al. Graphical Abstract
Disclosures and Contributions

Plasma Cell Disorders

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Subcutaneous versus intravenous bortezomib in two different induction therapies for newly diagnosed multiple myeloma: an interim analysis from the prospective GMMG-MM5 trial
Maximilian Merz, Hans Salwender, Mathias Haenel, Elias K. Mai, Uta Bertsch, Christina Kunz, Thomas Hielscher, Igor W. Blau, Christof Scheid, Dirk Hose, Anja Seckinger, Anna Jauch, Jens Hillengass, Marc S. Raab, Baerbel Schurich, Markus Munder, Ingo G.H. Schmidt-Wolf, Christian Gerecke, Hans-Walter Lindemann, Matthias Zeis, Katja Weisel, Jan Duerig, Hartmut Goldschmidt

Haematologica July 2015 100: 964-969; doi:10.3324/haematol.2015.124347
Merz et al. Supplementary Appendix
Disclosures and Contributions

Stem Cell Transplantation

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Prolonged sirolimus administration after allogeneic hematopoietic cell transplantation is associated with decreased risk for moderate-severe chronic graft-versus-host disease
Joseph Pidala, Jongphil Kim, Melissa Alsina, Ernesto Ayala, Brian C. Betts, Hugo F. Fernandez, Teresa Field, Heather Jim, Mohamed A. Kharfan-Dabaja, Frederick L. Locke, Asmita Mishra, Taiga Nishihori, Leonel Ochoa-Bayona, Lia Perez, Marcie Riches, Claudio Anasetti

Haematologica July 2015 100: 970-977; doi:10.3324/haematol.2015.123588
Disclosures and Contributions

Immunodeficiencies

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The syndrome of hemophagocytic lymphohistiocytosis in primary immunodeficiencies: implications for differential diagnosis and pathogenesis
Sebastian FN Bode, Sandra Ammann, Waleed Al-Herz, Mihaela Bataneant, Christopher C Dvorak, Stephan Gehring, Andrew Gennery, Kimberly C Gilmour, Luis I Gonzalez-Granado, Ute Groß-Wieltsch, Marianne Ifversen, Jenny Lingman-Framme, Susanne Matthes-Martin, Rolf Mesters, Isabelle Meyts, Joris M van Montfrans, Jana Pachlopnik Schmid, Sung-Yun Pai, Pere Soler-Palacin, Uta Schuermann, Volker Schuster, Markus G. Seidel, Carsten Speckmann, Polina Stepensky, Karl-Walter Sykora, Bianca Tesi, Thomas Vraetz, Catherine Waruiru, Yenan T. Bryceson, Despina Moshous, Kai Lehmberg, Michael B Jordan, Stephan Ehl

Haematologica July 2015 100: 978-988; doi:10.3324/haematol.2014.121608
Disclosures and Contributions

Online Only Articles

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Azacitidine as post-remission consolidation for sorafenib-induced remission of Fms-like tyrosine kinase-3 internal tandem duplication positive acute myeloid leukemia
Harinder Gill, Cheuk-Him Man, Alvin H.W. Ip, William W.L. Choi, Howard C.H. Chow, Yok-Lam Kwong, Anskar Y.H. Leung

Haematologica July 2015 100: e250-e253; doi:10.3324/haematol.2014.123034
Gill et al. Supplementary Appendix
Disclosures and Contributions
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Effect of allogeneic hematopoietic cell transplantation in first complete remission on post-relapse complete remission rate and survival in acute myeloid leukemia
Daisuke Araki, Megan Othus, Roland B. Walter, Vicky Sandhu, Brenda M. Sandmaier, Pamela S. Becker, Frederick R. Appelbaum, Elihu H. Estey

Haematologica July 2015 100: e254-e256; doi:10.3324/haematol.2014.118570
Araki et al. Supplementary Appendix
Disclosures and Contributions
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CD127⁺ innate lymphoid cells are dysregulated in treatment naïve acute myeloid leukemia patients at diagnosis
Sara Trabanelli, Antonio Curti, Mariangela Lecciso, Bérengère Salomé, Carsten Riether, Adrian Ochsenbein, Pedro Romero, Camilla Jandus

Haematologica July 2015 100: e257-e260; doi:10.3324/haematol.2014.119602
Disclosures and Contributions
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Expression profiling of adult acute lymphoblastic leukemia identifies a BCR-ABL1-like subgroup characterized by high non-response and relapse rates
Judith M. Boer, Jasper E. Koenders, Bronno van der Holt, Carla Exalto, Mathijs A. Sanders, Jan J. Cornelissen, Peter J.M. Valk, Monique L. den Boer, Anita W. Rijneveld

Haematologica July 2015 100: e261-e264; doi:10.3324/haematol.2014.117424
Boer et al. Supplementary Appendix
Disclosures and Contributions
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Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia
Adam Linley, Beatriz Valle-Argos, Andrew J. Steele, Freda K. Stevenson, Francesco Forconi, Graham Packham

Haematologica July 2015 100: e265-e268; doi:10.3324/haematol.2014.120824
Linley et al. Supplementary Appendix
Disclosures and Contributions
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Sequential combination of gemcitabine, vinorelbine, pegylated liposomal doxorubicin and brentuximab as a bridge regimen to transplant in relapsed or refractory Hodgkin lymphoma
Anne-Sophie Michallet, Yann Guillermin, Benedicte Deau, Laure Lebras, Stephanie Harel, Sandy Amorin, Claire Reynes, Gilles Salles, Fabien Subtil, Pauline Brice

Haematologica July 2015 100: e269-e271; doi:10.3324/haematol.2015.124784
Disclosures and Contributions
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Experience with HSP90 inhibitor AUY922 in patients with relapsed or refractory non-Hodgkin lymphoma
Yasuhiro Oki, Anas Younes, Javier Knickerbocker, Felipe Samaniego, Loretta Nastoupil, Fredrick Hagemeister, Jorge Romaguera, Nathan Fowler, Larry Kwak, Jason Westin

Haematologica July 2015 100: e272-e274; doi:10.3324/haematol.2015.126557
Disclosures and Contributions
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Post-transplant molecularly defined Burkitt lymphomas are frequently MYC-negative and characterized by the 11q-gain/loss pattern
Julio Finalet Ferreiro, Julie Morscio, Daan Dierickx, Lukas Marcelis, Gregor Verhoef, Peter Vandenberghe, Thomas Tousseyn, Iwona Wlodarska

Haematologica July 2015 100: e275-e279; doi:10.3324/haematol.2015.124305
Finalet Ferreiro et al. Supplementary Appendix
Disclosures and Contributions
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Somatic mutations of cell-free circulating DNA detected by next-generation sequencing reflect the genetic changes in both germinal center B-cell-like and activated B-cell-like diffuse large B-cell lymphomas at the time of diagnosis
Elodie Bohers, Pierre Julien Viailly, Sydney Dubois, Philippe Bertrand, Catherine Maingonnat, Sylvain Mareschal, Philippe Ruminy, Jean-Michel Picquenot, Christian Bastard, Fabienne Desmots, Thierry Fest, Karen Leroy, Hervé Tilly, Fabrice Jardin

Haematologica July 2015 100: e280-e284; doi:10.3324/haematol.2015.123612
Bohers et al. Supplementary Appendix
Disclosures and Contributions
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Efficacy of single versus boost vaccination against influenza virus in patients with multiple myeloma
Michael Hahn, Paul Schnitzler, Brunhilde Schweiger, Christina Kunz, Anthony D. Ho, Hartmut Goldschmidt, Michael Schmitt

Haematologica July 2015 100: e285-e288; doi:10.3324/haematol.2014.116772
Disclosures and Contributions
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Evidence of long-term disease control with panobinostat maintenance in patients with relapsed multiple myeloma
Enrique M. Ocio, Julio Dávila, Juan-Carlos Caballero, Sara Alonso, Verónica González de la Calle, Ramón García-Sanz, Lucien Gazi, Socrates Opio, Mónica Jiménez, Jesús F. San-Miguel, María-Victoria Mateos

Haematologica July 2015 100: e289-e291; doi:10.3324/haematol.2015.124164
Disclosures and Contributions

Table of Contents

Editorials

Review Article

Articles

Red Cell Biology & Its Disorders

Coagulation & Its Disorders

Myeloproliferative Disorders

Chronic Myeloid Leukemia

Acute Myeloid Leukemia

Acute Lymphoblastic Leukemia

Chronic Lymphocytic Leukemia

Non-Hodgkin Lymphoma

Plasma Cell Disorders

Stem Cell Transplantation

Immunodeficiencies

Online Only Articles

In this issue

Table of Contents

Editorials

Review Article

Articles

Red Cell Biology & Its Disorders

Coagulation & Its Disorders

Myeloproliferative Disorders

Chronic Myeloid Leukemia

Acute Myeloid Leukemia

Acute Lymphoblastic Leukemia

Chronic Lymphocytic Leukemia

Non-Hodgkin Lymphoma

Plasma Cell Disorders

Stem Cell Transplantation

Immunodeficiencies

Online Only Articles

In this issue

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