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Incidence and outcome of acquired aplastic anemia: real-world data from patients diagnosed in Sweden from 2000–2011
Krista Vaht, Magnus Göransson, Kristina Carlson, Cecilia Isaksson, Stig Lenhoff, Anna Sandstedt, Bertil Uggla, Jacek Winiarski, Per Ljungman, Mats Brune, Per-Ola Andersson
Haematologica October 2017 102: 1683-1690; doi:10.3324/haematol.2017.169862
Krista Vaht
Section of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg, Sweden Sahlgrenska Academy at Gothenburg University, Sweden
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  • For correspondence: krista.vaht@vgregion.se
Magnus Göransson
Department of Pediatrics, The Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Umeå, Sweden
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Kristina Carlson
Department of Hematology, Uppsala University Hospital, Umeå, Sweden
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Cecilia Isaksson
Department of Hematology, Cancer Centre, University Hospital, Umeå, Sweden
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Stig Lenhoff
Department of Hematology, Skåne University Hospital, Lund University, Stockholm, Sweden
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Anna Sandstedt
Department of Hematology, Linköping University Hospital, Stockholm, Sweden
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Bertil Uggla
Section of Hematology Department of Medicine, Faculty of Medicine and Health, Örebro University, Stockholm, Sweden
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Jacek Winiarski
Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
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Per Ljungman
Centre of allogeneic stem cell transplantation (CAST), Karolinska University Hospital Huddinge, Stockholm, Sweden
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Mats Brune
Section of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg, Sweden Sahlgrenska Academy at Gothenburg University, Sweden
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Per-Ola Andersson
South Älvsborg Hospital Borås, Sweden Sahlgrenska Academy at Gothenburg University, Sweden
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Author Affiliations

  1. Krista Vaht1,11⇑,
  2. Magnus Göransson2,
  3. Kristina Carlson3,
  4. Cecilia Isaksson4,
  5. Stig Lenhoff5,
  6. Anna Sandstedt6,
  7. Bertil Uggla7,
  8. Jacek Winiarski8,
  9. Per Ljungman9,
  10. Mats Brune1,11 and
  11. Per-Ola Andersson10,11
  1. 1Section of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg, Sweden
  2. 2Department of Pediatrics, The Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Umeå, Sweden
  3. 3Department of Hematology, Uppsala University Hospital, Umeå, Sweden
  4. 4Department of Hematology, Cancer Centre, University Hospital, Umeå, Sweden
  5. 5Department of Hematology, Skåne University Hospital, Lund University, Stockholm, Sweden
  6. 6Department of Hematology, Linköping University Hospital, Stockholm, Sweden
  7. 7Section of Hematology Department of Medicine, Faculty of Medicine and Health, Örebro University, Stockholm, Sweden
  8. 8Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
  9. 9Centre of allogeneic stem cell transplantation (CAST), Karolinska University Hospital Huddinge, Stockholm, Sweden
  10. 10South Älvsborg Hospital Borås, Sweden
  11. 11Sahlgrenska Academy at Gothenburg University, Sweden
  1. Correspondence:
    krista.vaht{at}vgregion.se
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Data supplements

  • Vaht et al. Supplementary Appendix

    Vaht et al. Supplementary figure and table provided by the authors.

    Files in this Data Supplement:

    • Adobe PDF - 2017.169862.VAHT_SUPPL.pdf
  • Disclosures and Contributions

    Files in this Data Supplement:

    • Adobe PDF - 2017_169862-Disclosures_and_Contributions.pdf

ARTICLE FIGURES & DATA

Figures

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    Figure 1.

    Overall survival. A. For all patients. B. In different age groups: 0–18 years, 19–39 years, 40–59 years, and ≥60 years.

  • Figure 2.
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    Figure 2.

    Overall survival according to disease severity at diagnosis (very severe, severe, and non-severe AA).

  • Figure 3.
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    Figure 3.

    Overall survival. A. According to primary treatment. B. For patients treated with IST divided into different age groups.

  • Figure 4.
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    Figure 4.

    Relative survival. A. For all patients. B. Divided into two age groups according to median age at diagnosis: < and ≥60 years.

Tables

  • Figures
  • Table 1.

    Clinical characteristics.

    Table 1.
  • Table 2.

    Primary treatment in different age groups.

    Table 2.
  • Table 3.

    Uni-and multivariable Cox-regression.

    Table 3.
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Haematologica: 102 (10)
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Incidence and outcome of acquired aplastic anemia: real-world data from patients diagnosed in Sweden from 2000–2011
Krista Vaht, Magnus Göransson, Kristina Carlson, Cecilia Isaksson, Stig Lenhoff, Anna Sandstedt, Bertil Uggla, Jacek Winiarski, Per Ljungman, Mats Brune, Per-Ola Andersson
Haematologica Oct 2017, 102 (10) 1683-1690; DOI: 10.3324/haematol.2017.169862

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Krista Vaht, Magnus Göransson, Kristina Carlson, Cecilia Isaksson, Stig Lenhoff, Anna Sandstedt, Bertil Uggla, Jacek Winiarski, Per Ljungman, Mats Brune, Per-Ola Andersson
Haematologica Oct 2017, 102 (10) 1683-1690; DOI: 10.3324/haematol.2017.169862
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