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Table of Contents

October 27, 2017 ;  102 (11)

Editorial

  • You have access
    Understanding the extracellular matrix in acute myeloid leukemia
    Valerio Izzi, Ritva Heljasvaara, Taina Pihlajaniemi
    Haematologica November 2017 102: 1807-1809; doi:10.3324/haematol.2017.174847
    • Disclosures and Contributions

Guideline Article

  • Open Access
    Haploidentical hematopoietic cell transplantation for adult acute myeloid leukemia: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
    Catherine J Lee, Bipin N Savani, Mohamad Mohty, Myriam Labopin, Annalisa Ruggeri, Christoph Schmid, Frédéric Baron, Jordi Esteve, Norbert C Gorin, Sebastian Giebel, Fabio Ciceri, Arnon Nagler
    Haematologica November 2017 102: 1810-1822; doi:10.3324/haematol.2017.176107
    • Disclosures and Contributions

Articles

  • Red Cell Biology & Its Disorders

    • Open Access
      Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases
      Staci D. Arnold, Ruta Brazauskas, Naya He, Yimei Li, Richard Aplenc, Zhezhen Jin, Matt Hall, Yoshiko Atsuta, Jignesh Dalal, Theresa Hahn, Nandita Khera, Carmem Bonfim, Navneet S. Majhail, Miguel Angel Diaz, Cesar O. Freytes, William A. Wood, Bipin N. Savani, Rammurti T. Kamble, Susan Parsons, Ibrahim Ahmed, Keith Sullivan, Sara Beattie, Christopher Dandoy, Reinhold Munker, Susana Marino, Menachem Bitan, Hisham Abdel-Azim, Mahmoud Aljurf, Richard F. Olsson, Sarita Joshi, Dave Buchbinder, Michael J. Eckrich, Shahrukh Hashmi, Hillard Lazarus, David I. Marks, Amir Steinberg, Ayman Saad, Usama Gergis, Lakshmanan Krishnamurti, Allistair Abraham, Hemalatha G. Rangarajan, Mark Walters, Joseph Lipscomb, Wael Saber, Prakash Satwani
      Haematologica November 2017 102: 1823-1832; doi:10.3324/haematol.2017.169581
      • Arnold et al. Supplementary Appendix
      • Disclosures and Contributions
  • Coagulation & Its Disorders

    • Open Access
      The ADAMTS131239–1253 peptide is a dominant HLA-DR1-restricted CD4+ T-cell epitope
      Laurent Gilardin, Sandrine Delignat, Ivan Peyron, Mathieu Ing, Yu-Chun Lone, Bagirath Gangadharan, Baptiste Michard, Yousra Kherabi, Meenu Sharma, Anastas Pashov, Jean-Baptiste Latouche, Mohamad Hamieh, Olivier Toutirais, Pascale Loiseau, Lionel Galicier, Agnès Veyradier, Srini Kaveri, Bernard Maillère, Paul Coppo, Sébastien Lacroix-Desmazes
      Haematologica November 2017 102: 1833-1841; doi:10.3324/haematol.2015.136671
      • Disclosures and Contributions
  • Chronic Myeloid Leukemia

    • Open Access
      Treatment outcome in a population-based, ‘real-world’ cohort of patients with chronic myeloid leukemia
      Inge G.P. Geelen, Noortje Thielen, Jeroen J.W.M. Janssen, Mels Hoogendoorn, Tanja J.A. Roosma, Sten P. Willemsen, Otto Visser, Jan J. Cornelissen, Peter E. Westerweel
      Haematologica November 2017 102: 1842-1849; doi:10.3324/haematol.2017.174953
      • Geelen et al. Graphical Abstract
      • Geelen et al. Supplementary Appendix
      • Disclosures and Contributions
  • Acute Myeloid Leukemia

    • Open Access
      Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells
      Laure Delestré, Hengxiang Cui, Michela Esposito, Cyril Quiveron, Elena Mylonas, Virginie Penard-Lacronique, Oliver Bischof, Christel Guillouf
      Haematologica November 2017 102: 1850-1860; doi:10.3324/haematol.2016.157636
      • Delestre et al. Graphical Abstract
      • Disclosures and Contributions
      • Delestre et al. Supplementary Appendix
    • Open Access
      Bortezomib as a new therapeutic approach for blastic plasmacytoid dendritic cell neoplasm
      Laure Philippe, Adam Ceroi, Elodie Bôle-Richard, Alizée Jenvrin, Sabeha Biichle, Sophie Perrin, Samuel Limat, Francis Bonnefoy, Eric Deconinck, Philippe Saas, Francine Garnache-Ottou, Fanny Angelot-Delettre
      Haematologica November 2017 102: 1861-1868; doi:10.3324/haematol.2017.169326
      • Philippe et al. Supplementary Appendix
      • Disclosures and Contributions
  • Acute Lymphoblastic Leukemia

    • Open Access
      Antigen receptor sequencing of paired bone marrow samples shows homogeneous distribution of acute lymphoblastic leukemia subclones
      Prisca M.J. Theunissen, David van Zessen, Andrew P. Stubbs, Malek Faham, Christian M. Zwaan, Jacques J.M. van Dongen, Vincent H.J. Van Der Velden
      Haematologica November 2017 102: 1869-1877; doi:10.3324/haematol.2017.171454
      • Theunissen et al. Supplementary Appendix
      • Disclosures and Contributions
  • Chronic Lymphocytic Leukemia

    • Open Access
      Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor
      Tiziana Vaisitti, Federica Gaudino, Samedy Ouk, Maria Moscvin, Nicoletta Vitale, Sara Serra, Francesca Arruga, Johannes L. Zakrzewski, Hsiou-Chi Liou, John N. Allan, Richard R. Furman, Silvia Deaglio
      Haematologica November 2017 102: 1878-1889; doi:10.3324/haematol.2017.173419
      • Vaisitti et al. Graphical Abstract
      • Vaisitti et al. Supplementary Appendix
      • Disclosures and Contributions
    • Open Access
      SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia
      Cody Paiva, Taylor A. Rowland, Bhargava Sreekantham, Claire Godbersen, Scott R. Best, Prabhjot Kaur, Marc M. Loriaux, Stephen E.F. Spurgeon, Olga V. Danilova, Alexey V. Danilov
      Haematologica November 2017 102: 1890-1900; doi:10.3324/haematol.2017.170571
      • Paiva et al. Supplementary Appendix
      • Disclosures and Contributions
    • Open Access
      Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells
      Eleonora Fonte, Maria Giovanna Vilia, Daniele Reverberi, Ilenia Sana, Lydia Scarfò, Pamela Ranghetti, Ugo Orfanelli, Simone Cenci, Giovanna Cutrona, Paolo Ghia, Marta Muzio
      Haematologica November 2017 102: 1901-1912; doi:10.3324/haematol.2017.165878
      • Fonte et al. Supplementary Appendix
      • Disclosures and Contributions
  • Non-Hodgkin Lymphoma

    • Open Access
      Efficacy and safety of subcutaneous and intravenous rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in first-line diffuse large B-cell lymphoma: the randomized MabEase study
      Pieternella Lugtenburg, Irit Avivi, Henriette Berenschot, Osman Ilhan, Jean Pierre Marolleau, Arnon Nagler, Antonio Rueda, Monica Tani, Mehmet Turgut, Stuart Osborne, Rodney Smith, Michael Pfreundschuh
      Haematologica November 2017 102: 1913-1922; doi:10.3324/haematol.2017.173583
      • Lugtenburg et al. Supplementary Appendix
      • Disclosures and Contributions
    • Open Access
      CUDC-907 in relapsed/refractory diffuse large B-cell lymphoma, including patients with MYC-alterations: results from an expanded phase I trial
      Yasuhiro Oki, Kevin R Kelly, Ian Flinn, Manish R. Patel, Robert Gharavi, Anna Ma, Jefferson Parker, Amir Hafeez, David Tuck, Anas Younes
      Haematologica November 2017 102: 1923-1930; doi:10.3324/haematol.2017.172882
      • Oki et al. Supplementary Appendix
      • Disclosures and Contributions
    • Open Access
      Italian real-life experience with brentuximab vedotin: results of a large observational study of 40 cases of relapsed/refractory systemic anaplastic large cell lymphoma
      Alessandro Broccoli, Cinzia Pellegrini, Alice Di Rocco, Benedetta Puccini, Caterina Patti, Guido Gini, Donato Mannina, Monica Tani, Chiara Rusconi, Alessandra Romano, Anna Vanazzi, Barbara Botto, Carmelo Carlo-Stella, Stefan Hohaus, Pellegrino Musto, Patrizio Mazza, Stefano Molica, Paolo Corradini, Angelo Fama, Francesco Gaudio, Michele Merli, Angela Gravetti, Giuseppe Gritti, Annalisa Arcari, Patrizia Tosi, Anna Marina Liberati, Antonello Pinto, Vincenzo Pavone, Filippo Gherlinzoni, Virginia Naso, Stefano Volpetti, Livio Trentin, Maria Cecilia Goldaniga, Maurizio Bonfichi, Amalia De Renzo, Corrado Schiavotto, Michele Spina, Sergio Storti, Angelo Michele Carella, Vittorio Stefoni, Lisa Argnani, Pier Luigi Zinzani
      Haematologica November 2017 102: 1931-1935; doi:10.3324/haematol.2017.171355
      • Broccoli et al. Graphical Abstract
      • Disclosures and Contributions
  • Cell Therapy & Immunotherapy

    • Open Access
      CD56bright natural killer regulatory cells in filgrastim primed donor blood or marrow products regulate chronic graft-versus-host disease: the Canadian Blood and Marrow Transplant Group randomized 0601 study results
      Amina Kariminia, Sabine Ivison, Bernard Ng, Jacob Rozmus, Susanna Sung, Avani Varshney, Mahmoud Aljurf, Sylvie Lachance, Irwin Walker, Cindy Toze, Jeff Lipton, Stephanie J. Lee, Jeff Szer, Richard Doocey, Ian Lewis, Clayton Smith, Naeem Chaudhri, Megan K. Levings, Raewyn Broady, Gerald Devins, David Szwajcer, Ronan Foley, Sara Mostafavi, Steven Pavletic, Donna A. Wall, Stephan Couban, Tony Panzarella, Kirk R. Schultz
      Haematologica November 2017 102: 1936-1946; doi:10.3324/haematol.2017.170928
      • Kariminia et al. Supplementary Appendix
      • Disclosures and Contributions
    • Open Access
      Human leukocyte antigen-E mismatch is associated with better hematopoietic stem cell transplantation outcome in acute leukemia patients
      Chrysanthi Tsamadou, Daniel Fürst, Vladan Vucinic, Donald Bunjes, Christine Neuchel, Daphne Mytilineos, Martin Gramatzki, Renate Arnold, Eva Maria Wagner, Hermann Einsele, Carlheinz Müller, Hubert Schrezenmeier, Joannis Mytilineos
      Haematologica November 2017 102: 1947-1955; doi:10.3324/haematol.2017.169805
      • Tsamadou et al. Graphical Abstract
      • Tsamadou et al. Supplementary Appendix
      • Disclosures and Contributions
  • Complications in Hematology

    • Open Access
      HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis
      Rui Huang, Yoshihiro Hayashi, Xiaomei Yan, Jiachen Bu, Jieyu Wang, Yue Zhang, Yile Zhou, Yuting Tang, Lingyun Wu, Zefeng Xu, Xin Liu, Qianfei Wang, Jianfeng Zhou, Zhijian Xiao, James P. Bridges, Rebecca A. Marsh, Kejian Zhang, Michael B. Jordan, Yuhua Li, Gang Huang
      Haematologica November 2017 102: 1956-1968; doi:10.3324/haematol.2017.174979
      • Huang et al. Supplementary Appendix
      • Disclosures and Contributions

Letters to the Editor

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    Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow
    Erica L. Clinkenbeard, Mark R. Hanudel, Keith R. Stayrook, Hitesh Nidumanda Appaiah, Emily G. Farrow, Taryn A. Cass, Lelia J. Summers, Colin S. Ip, Julia M. Hum, Joseph C. Thomas, Mircea Ivan, Briana M. Richine, Rebecca J. Chan, Thomas L. Clemens, Ernestina Schipani, Yves Sabbagh, Linlin Xu, Edward F. Srour, Marta B. Alvarez, Melissa A. Kacena, Isidro B. Salusky, Tomas Ganz, Elizabeta Nemeth, Kenneth E. White
    Haematologica November 2017 102: e427-e430; doi:10.3324/haematol.2017.167882
    • Clinkenbeard et al. Supplementary Appendix
    • Disclosures and Contributions
  • You have access
    Increase of von Willebrand factor with aging in type 1 von Willebrand disease: fact or fiction?
    Mariachiara Borghi, Giuseppe Guglielmini, Anna Maria Mezzasoma, Emanuela Falcinelli, Loredana Bury, Marco Malvestiti, Paolo Gresele
    Haematologica November 2017 102: e431-e433; doi:10.3324/haematol.2017.168013
    • Disclosures and Contributions
  • You have access
    MLL-TET1 fusion protein promotes immortalization of myeloid progenitor cells and leukemia development
    Hyeng-Soo Kim, Seung Hwan Oh, Ju-Heon Kim, Jae-Young Kim, Do-Hyung Kim, Soo-Jin Lee, Sang-Un Choi, Kwon Moo Park, Zae Young Ryoo, Tae Sung Park, Sanggyu Lee
    Haematologica November 2017 102: e434-e437; doi:10.3324/haematol.2017.169789
    • Disclosures and Contributions
  • You have access
    The role of constitutive activation of FMS-related tyrosine kinase-3 and NRas/KRas mutational status in infants with KMT2A-rearranged acute lymphoblastic leukemia
    Henning Fedders, Ameera Alsadeq, Juliane Schmäh, Fotini Vogiatzi, Martin Zimmermann, Anja Möricke, Lennart Lenk, Udo zur Stadt, Martin A. Horstmann, Rob Pieters, Martin Schrappe, Martin Stanulla, Gunnar Cario, Denis M. Schewe
    Haematologica November 2017 102: e438-e442; doi:10.3324/haematol.2017.169870
    • Fedders et al. Supplementary Appendix
    • Disclosures and Contributions
  • You have access
    Mutational status of IGHV is the most reliable prognostic marker in trisomy 12 chronic lymphocytic leukemia
    Pietro Bulian, Riccardo Bomben, Michele Dal Bo, Antonella Zucchetto, Francesca Maria Rossi, Massimo Degan, Federico Pozzo, Tamara Bittolo, Vanessa Bravin, Tiziana D’Agaro, Michaela Cerri, Annalisa Chiarenza, Kari G. Chaffee, Adalgisa Condoluci, Giovanni D’Arena, Michele Spina, Francesco Zaja, Gabriele Pozzato, Francesco Di Raimondo, Davide Rossi, Giovanni Del Poeta, Gianluca Gaidano, Tait D. Shanafelt, Valter Gattei
    Haematologica November 2017 102: e443-e446; doi:10.3324/haematol.2017.170340
    • Bulian et al. Supplementary Appendix
    • Disclosures and Contributions
  • You have access
    The Bruton tyrosine kinase inhibitor CC-292 shows activity in mantle cell lymphoma and synergizes with lenalidomide and NIK inhibitors depending on nuclear factor-κB mutational status
    Anna Vidal-Crespo, Vanina Rodriguez, Alba Matas-Cespedes, Eriong Lee, Alfredo Rivas-Delgado, Eva Giné, Alba Navarro, Sílvia Beà, Elias Campo, Armando López-Guillermo, Monica Lopez-Guerra, Gaël Roué, Dolors Colomer, Patricia Pérez-Galán
    Haematologica November 2017 102: e447-e451; doi:10.3324/haematol.2017.168930
    • Vidal-Crespo et al. Supplementary Appendix
    • Disclosures and Contributions
  • You have access
    CXCL13 levels are elevated in patients with Waldenström macroglobulinemia, and are predictive of major response to ibrutinib
    Josephine M. Vos, Nickolas Tsakmaklis, Christopher J. Patterson, Kirsten Meid, Jorge J. Castillo, Philip Brodsky, Tomas Ganz, Steven T. Pals, Marie José Kersten, Lian Xu, Guang Yang, Steven P. Treon, Zachary R. Hunter
    Haematologica November 2017 102: e452-e455; doi:10.3324/haematol.2017.172627
    • Vos et al. Supplementary Appendix
    • Disclosures and Contributions
  • You have access
    Circulating microRNA expressions can predict the outcome of lenalidomide plus low-dose dexamethasone treatment in patients with refractory/relapsed multiple myeloma
    Seung-Hyun Jung, Sung-Eun Lee, Minho Lee, So-Hee Kim, Seon-Hee Yim, Tae Woo Kim, Chang-Ki Min, Yeun-Jun Chung
    Haematologica November 2017 102: e456-e459; doi:10.3324/haematol.2017.168070
    • Jung et al. Supplementary Appendix
    • Disclosures and Contributions
  • You have access
    Mass spectrometry-based identification of a naturally presented receptor tyrosine kinase-like orphan receptor 1-derived epitope recognized by CD8+ cytotoxic T cells
    Falk Heidenreich, Elke Rücker-Braun, Juliane S. Walz, Anne Eugster, Denise Kühn, Sevina Dietz, Annika Nelde, Antje Tunger, Rebekka Wehner, Cornelia S. Link, Jan M. Middeke, Friedrich Stölzel, Torsten Tonn, Stefan Stevanovic, Hans-Georg Rammensee, Ezio Bonifacio, Michael Bachmann, Matthias Zeis, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig, Marc Schmitz
    Haematologica November 2017 102: e460-e464; doi:10.3324/haematol.2017.167312
    • Heidenreich et al. Supplementary Appendix
    • Disclosures and Contributions

Comment

  • You have access
    Late effects of blood and marrow transplantation
    Rahul Banerjee, Marlise R. Luskin, Alison W. Loren
    Haematologica November 2017 102: e465; doi:10.3324/haematol.2017.176289
    • Disclosures and Contributions

Case Reports

  • You have access
    Pseudo-monoclonal gammopathy: a report of four cases
    Majd D. Jawad, Ronald S. Go, Thomas E. Witzig, Joseph R. Mikhael, Aishwarya Ravindran, David L. Murrray
    Haematologica November 2017 102: e466-e469; doi:10.3324/haematol.2017.171694
    • Jawad et al. Supplementary Appendix
    • Disclosures and Contributions
  • You have access
    ARID1A mutation in blastic plasmacytoid dendritic cell neoplasm
    Lei Wang, Min Yang, Xiang Zhang, Chunmei Yang, Xin Huang, Zhaoming Wang, Jie Jin
    Haematologica November 2017 102: e470-e472; doi:10.3324/haematol.2017.172742
    • Disclosures and Contributions
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Haematologica: 102 (11)
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