Table of Contents

Articles

• Hematopoiesis

  • Open Access

    Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis

    Zengdi Zhang, Zan Huang, Brianna Ong, Chinmayi Sahu, Hu Zeng, Hai-Bin Ruan

    Haematologica September 2019 104: 1731-1743; doi:10.3324/haematol.2018.205856

    • Zhang et al. Graphical Abstract
    • Zhang et al. Supplementary Appendix
    • Disclosures and Contributions
  • Open Access

    MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation

    Laura Crisafulli, Sharon Muggeo, Paolo Uva, Yulei Wang, Masayuki Iwasaki, Silvia Locatelli, Achille Anselmo, Federico S. Colombo, Carmelo Carlo-Stella, Michael L. Cleary, Anna Villa, Bernhard Gentner, Francesca Ficara

    Haematologica September 2019 104: 1744-1755; doi:10.3324/haematol.2018.198499

    • Crisafulli et al. Supplementary Appendix
    • Disclosures and Contributions

• Iron Metabolism & its Disorders

  • Open Access

    Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis

    Nunziata Maio, Ki Soon Kim, Gregory Holmes-Hampton, Anamika Singh, Tracey A. Rouault

    Haematologica September 2019 104: 1756-1767; doi:10.3324/haematol.2018.214320

    • Maio et al. Supplementary Appendix
    • Disclosures and Contributions
  • Open Access

    New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia

    Jing Liu, Wei Liu, Yin Liu, Yang Miao, Yifan Guo, Haoyang Song, Fudi Wang, Hongyu Zhou, Tomas Ganz, Bing Yan, Sijin Liu

    Haematologica September 2019 104: 1768-1781; doi:10.3324/haematol.2018.209874

    • Liu et al. Graphical Abstract
    • Liu et al. Supplementary Appendix
    • Disclosures and Contributions

• Myeloproliferative Neoplasms

  • Open Access

    Long-term outcome after allogeneic hematopoietic cell transplantation for myelofibrosis

    Marie Robin, Liesbeth C. de Wreede, Christine Wolschke, Johannes Schetelig, Diderik-Jan Eikema, Maria Teresa Van Lint, Nina Simone Knelange, Dietrich Beelen, Arne Brecht, Dietger Niederwieser, Antonin Vitek, Wolfgang Bethge, Renate Arnold, Jürgen Finke, Liisa Volin, Ibrahim Yakoub-Agha, Arnon Nagler, Xavier Poiré, Hermann Einsele, Patrice Chevallier, Ernst Holler, Per Ljungman, Stephen Robinson, Alekxandar Radujkovic, Donal McLornan, Yves Chalandon, Nicolaus Kröger

    Haematologica September 2019 104: 1782-1788; doi:10.3324/haematol.2018.205211

    • Disclosures and Contributions

• Chronic Myeloid Leukemia

  • Open Access

    De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways

    Vera Magistroni, Mario Mauri, Deborah D’Aliberti, Caterina Mezzatesta, Ilaria Crespiatico, Miriam Nava, Diletta Fontana, Nitesh Sharma, Wendy Parker, Andreas Schreiber, David Yeung, Alessandra Pirola, Sara Readelli, Luca Massimino, Paul Wang, Praveen Khandelwal, Stefania Citterio, Michela Viltadi, Silvia Bombelli, Roberta Rigolio, Roberto Perego, Jacqueline Boultwood, Alessandro Morotti, Giuseppe Saglio, Dong-Wook Kim, Susan Branford, Carlo Gambacorti-Passerini, Rocco Piazza

    Haematologica September 2019 104: 1789-1797; doi:10.3324/haematol.2017.179937

    • Magistroni et al. Graphical Abstract
    • Magistroni et al. Supplementary Appendix
    • Disclosures and Contributions

• Acute Myeloid Leukemia

  • Open Access

    Sequential therapy for patients with primary refractory acute myeloid leukemia: a historical prospective analysis of the German and Israeli experience

    Ron Ram, Christof Scheid, Odelia Amit, Jens Markus Chemnitz, Yakir Moshe, Michael Hallek, Dominik Wolf, Irit Avivi, Udo Holtick

    Haematologica September 2019 104: 1798-1803; doi:10.3324/haematol.2018.203869

    • Ram et al. Supplementary Appendix
    • Disclosures and Contributions

• Acute Lymphoblastic Leukemia

  • Open Access

    Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM

    Elizabeth C. Matheson, Huw Thomas, Marian Case, Helen Blair, Rosanna K. Jackson, Dino Masic, Gareth Veal, Chris Halsey, David R. Newell, Josef Vormoor, Julie A.E. Irving

    Haematologica September 2019 104: 1804-1811; doi:10.3324/haematol.2017.185975

    • Matheson et al. Supplementary Appendix
    • Disclosures and Contributions
  • Open Access

    Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study

    Carmelo Rizzari, Claudia Lanvers-Kaminsky, Maria Grazia Valsecchi, Andrea Ballerini, Cristina Matteo, Joachim Gerss, Gudrun Wuerthwein, Daniela Silvestri, Antonella Colombini, Valentino Conter, Andrea Biondi, Martin Schrappe, Anja Moericke, Martin Zimmermann, Arend von Stackelberg, Christin Linderkamp, Michael C. Frühwald, Sabine Legien, Andishe Attarbaschi, Bettina Reismüller, David Kasper, Petr Smisek, Jan Stary, Luciana Vinti, Elena Barisone, Rosanna Parasole, Concetta Micalizzi, Massimo Zucchetti, Joachim Boos

    Haematologica September 2019 104: 1812-1821; doi:10.3324/haematol.2018.206433

    • Disclosures and Contributions

• Non-Hodgkin Lymphoma

  • Open Access

    Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma

    Blanca Gonzalez-Farre, Joan Enric Ramis-Zaldivar, Julia Salmeron-Villalobos, Olga Balagué, Verónica Celis, Jaime Verdu-Amoros, Ferran Nadeu, Constantino Sábado, Antonio Ferrández, Marta Garrido, Federico García-Bragado, María Dolores de la Maya, José Manuel Vagace, Carlos Manuel Panizo, Itziar Astigarraga, Mara Andrés, Elaine S. Jaffe, Elias Campo, Itziar Salaverria

    Haematologica September 2019 104: 1822-1829; doi:10.3324/haematol.2018.207928

    • Gonzalez-Farre et al. Supplementary Appendix
    • Disclosures and Contributions

• Chronic Lymphocytic Leukemia

  • Open Access

    Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity

    Junyan Lu, Martin Böttcher, Tatjana Walther, Dimitrios Mougiakakos, Thorsten Zenz, Wolfgang Huber

    Haematologica September 2019 104: 1830-1840; doi:10.3324/haematol.2018.203067

    • Lu et al. Supplementary Appendix
    • Disclosures and Contributions

• Cell Therapy & Immunotherapy

  • Open Access

    CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering

    Simone C. Oostindie, Hilma J. van der Horst, Margaret A. Lindorfer, Erika M. Cook, Jillian C. Tupitza, Clive S. Zent, Richard Burack, Karl R. VanDerMeid, Kristin Strumane, Martine E. D. Chamuleau, Tuna Mutis, Rob N. de Jong, Janine Schuurman, Esther C. W. Breij, Frank J. Beurskens, Paul W. H. I. Parren, Ronald P. Taylor

    Haematologica September 2019 104: 1841-1852; doi:10.3324/haematol.2018.207266

    • Oostindie et al. Graphical Abstract
    • Oostindie et al. Supplementary Appendix
    • Disclosures and Contributions

• Platelet Biology & its Disorders

  • Open Access

    CD45 expression discriminates waves of embryonic megakaryocytes in the mouse

    Isabel Cortegano, Natalia Serrano, Carolina Ruiz, Mercedes Rodríguez, Carmen Prado, Mario Alía, Andrés Hidalgo, Eva Cano, Belén de Andrés, María-Luisa Gaspar

    Haematologica September 2019 104: 1853-1865; doi:10.3324/haematol.2018.192559

    • Cortegano et al. Supplementary Appendix
    • Disclosures and Contributions
  • Open Access

    Fatal dysfunction and disintegration of thrombin-stimulated platelets

    Oleg V. Kim, Tatiana A. Nevzorova, Elmira R. Mordakhanova, Anastasia A. Ponomareva, Izabella A. Andrianova, Giang Le Minh, Amina G. Daminova, Alina D. Peshkova, Mark S. Alber, Olga Vagin, Rustem I. Litvinov, John W. Weisel

    Haematologica September 2019 104: 1866-1878; doi:10.3324/haematol.2018.202309

    • Kim et al. Graphical Abstract
    • Kim et al. Supplementary Appendix
    • Disclosures and Contributions
  • Open Access

    A novel combinatorial technique for simultaneous quantification of oxygen radicals and aggregation reveals unexpected redox patterns in the activation of platelets by different physiopathological stimuli

    Dina Vara, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Giordano Pula

    Haematologica September 2019 104: 1879-1891; doi:10.3324/haematol.2018.208819

    • Vara et al. Supplementary Appendix
    • Disclosures and Contributions

• Hemostasis

  • Open Access

    Tspan18 is a novel regulator of the Ca²⁺ channel Orai1 and von Willebrand factor release in endothelial cells

    Peter J. Noy, Rebecca L. Gavin, Dario Colombo, Elizabeth J. Haining, Jasmeet S. Reyat, Holly Payne, Ina Thielmann, Adam B. Lokman, Georgiana Neag, Jing Yang, Tammy Lloyd, Neale Harrison, Victoria L. Heath, Chris Gardiner, Katharine M. Whitworth, Joseph Robinson, Chek Z. Koo, Alessandro Di Maio, Paul Harrison, Steven P. Lee, Francesco Michelangeli, Neena Kalia, G. Ed Rainger, Bernhard Nieswandt, Alexander Brill, Steve P. Watson, Michael G. Tomlinson

    Haematologica September 2019 104: 1892-1905; doi:10.3324/haematol.2018.194241

    • Noy et al. Supplementary Appendix
    • Disclosures and Contributions