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Rare variants lowering the levels of coagulation factor X are protective against ischemic heart disease

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;Humanitas Clinical and Research Center, Rozzano, Italy
Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;Department of Medicine, Massachusetts General Hospital, Cardiology Division, Harvard Medical School, Boston, MA, USA;Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Division of Cardiology, Azienda Ospedaliera Ospedale Niguarda Cà Granda, Milan, Italy
Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Luigi Villa Foundation, Milan, Italy;Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;Department of Medicine, Massachusetts General Hospital, Cardiology Division, Harvard Medical School, Boston, MA, USA;Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Luigi Villa Foundation, Milan, Italy
Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;Department of Medicine, Massachusetts General Hospital, Cardiology Division, Harvard Medical School, Boston, MA, USA;Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;Humanitas Clinical and Research Center, Rozzano, Italy
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;Humanitas Clinical and Research Center, Rozzano, Italy
Vol. 105 No. 7 (2020): July, 2020 https://doi.org/10.3324/haematol.2019.237750