Author Affiliations

  1. D Scribano,
  2. S Baroni,
  3. L Pagano,
  4. C Zuppi,
  5. G Leone and
  6. B Giardina
  1. Institute of Chemistry and Clinical Chemistry, Universita Cattolica S.Cuore, Roma, Italy.

Abstract

In the present work we investigated HDL-C and its subfractions HDL2 and HDL3 as well as total cholesterol (TC), triglycerides (TG), LDL-C, VLDL-C, apolipoproteins A1 (ApoA1) and B (ApoB) and lipoprotein (a) (Lp(a) in 25 patients with newly diagnosed acute lymphocytic leukemia (ALL) before and after induction treatment. The mean basal plasma levels of TC, HDL-C and its subfractions, LDL-C, and ApoA1 were significantly lower than the mean values observed in normal subjects, whereas TG and VLDL-C were significantly higher. The patients (n = 22) who achieved complete remission after chemotherapy showed a significant increase of TC, HDL-C, HDL2, HDL3, ApoA1 and a significant decrease of TG and VLDL-C. These data suggest that ALL patients are characterized by a lipid metabolic derangement mainly of HDL and TG-rich lipoproteins, that is reversed by effective treatment of disease.