Late response to donor lymphocyte infusions in patients with chronic myeloid leukemia relapsing after allogeneic stem cell transplantation

Abstract

Donor lymphocyte infusions were given to 13 consecutive chronic myeloid leukemia patients in relapse after allogeneic stem cell transplantation. Of the 13 patients, 11 achieved a molecular remission and 2 a cytogenetic remission. The median time (range) in months to achieve a hematologic, cytogenetic and molecular remission was 2 (1-2), 5 (1-42) and 5 the median response duration is 16 months (range 1-36), and no patient shows evidence of relapse.