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An enzyme-linked immunosorbent assay to screen for inhibitors of the oncogenic anaplastic lymphoma kinase
RH Gunby, CJ Tartari, F Porchia, A Donella-Deana, L Scapozza, C Gambacorti-Passerini
Haematologica January 2005 90: 988-990; doi:
RH Gunby
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CJ Tartari
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F Porchia
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A Donella-Deana
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L Scapozza
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C Gambacorti-Passerini
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Author Affiliations

  1. RH Gunby,
  2. CJ Tartari,
  3. F Porchia,
  4. A Donella-Deana,
  5. L Scapozza and
  6. C Gambacorti-Passerini
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Abstract

The discovery of novel anti-cancer drugs targeting anaplastic lymphoma kinase (ALK), an oncogenic tyrosine kinase, raises the need for in vitro assays suitable for screening compounds for ALK inhibition. To this aim we have developed and optimized an ALK-specific enzyme-linked immunosorbent assay that employs a novel ALK peptide substrate and purified ALK kinase domain.

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Vol 90 Issue 7

Haematologica: 90 (7)
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An enzyme-linked immunosorbent assay to screen for inhibitors of the oncogenic anaplastic lymphoma kinase
RH Gunby, CJ Tartari, F Porchia, A Donella-Deana, L Scapozza, C Gambacorti-Passerini
Haematologica Jan 2005, 90 (7) 988-990;

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RH Gunby, CJ Tartari, F Porchia, A Donella-Deana, L Scapozza, C Gambacorti-Passerini
Haematologica Jan 2005, 90 (7) 988-990;
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