Author Affiliations
- RH Gunby,
- CJ Tartari,
- F Porchia,
- A Donella-Deana,
- L Scapozza and
- C Gambacorti-Passerini
Abstract
The discovery of novel anti-cancer drugs targeting anaplastic lymphoma kinase (ALK), an oncogenic tyrosine kinase, raises the need for in vitro assays suitable for screening compounds for ALK inhibition. To this aim we have developed and optimized an ALK-specific enzyme-linked immunosorbent assay that employs a novel ALK peptide substrate and purified ALK kinase domain.
Vol 90 Issue 7
