Author Affiliations
- B Friedrichs,
- M Tiemann,
- H Salwender,
- K Verpoort,
- MK Wenger and
- N Schmitz
Abstract
A 35-year old woman developed Burkitt's lymphoma and was treated with rituximab and CHOP therapy early during pregnancy. Monitoring of rituximab concentrations and B-cell counts in the child revealed a transient complete B-cell depletion associated with high rituximab cord blood concentrations. B-cell recovery was fast, showing a regular immunophenotype without loss of CD20 antigen, no functional deficits and adequate vaccination IgG titers.
Vol 91 Issue 10
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