The effects of rituximab treatment during pregnancy on a neonate
B Friedrichs, M Tiemann, H Salwender, K Verpoort, MK Wenger, N Schmitz
Haematologica January 2006 91: 1426-1427; doi:

Author Affiliations

  1. B Friedrichs,
  2. M Tiemann,
  3. H Salwender,
  4. K Verpoort,
  5. MK Wenger and
  6. N Schmitz

Abstract

A 35-year old woman developed Burkitt's lymphoma and was treated with rituximab and CHOP therapy early during pregnancy. Monitoring of rituximab concentrations and B-cell counts in the child revealed a transient complete B-cell depletion associated with high rituximab cord blood concentrations. B-cell recovery was fast, showing a regular immunophenotype without loss of CD20 antigen, no functional deficits and adequate vaccination IgG titers.

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