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The effects of rituximab treatment during pregnancy on a neonate
B Friedrichs, M Tiemann, H Salwender, K Verpoort, MK Wenger, N Schmitz
Haematologica January 2006 91: 1426-1427; doi:
B Friedrichs
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M Tiemann
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H Salwender
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K Verpoort
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MK Wenger
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N Schmitz
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Author Affiliations

  1. B Friedrichs,
  2. M Tiemann,
  3. H Salwender,
  4. K Verpoort,
  5. MK Wenger and
  6. N Schmitz
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Abstract

A 35-year old woman developed Burkitt's lymphoma and was treated with rituximab and CHOP therapy early during pregnancy. Monitoring of rituximab concentrations and B-cell counts in the child revealed a transient complete B-cell depletion associated with high rituximab cord blood concentrations. B-cell recovery was fast, showing a regular immunophenotype without loss of CD20 antigen, no functional deficits and adequate vaccination IgG titers.

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Vol 91 Issue 10

Haematologica: 91 (10)
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The effects of rituximab treatment during pregnancy on a neonate
B Friedrichs, M Tiemann, H Salwender, K Verpoort, MK Wenger, N Schmitz
Haematologica Jan 2006, 91 (10) 1426-1427;

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B Friedrichs, M Tiemann, H Salwender, K Verpoort, MK Wenger, N Schmitz
Haematologica Jan 2006, 91 (10) 1426-1427;
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More in this TOC Section

  • Leukemic presentation of ALK-positive anaplastic large cell lymphoma with a novel partner, poly(A) binding protein cytoplasmic 1 (PABPC1), responding to single-agent crizotinib
  • Venetoclax plus rituximab or obinutuzumab after allogeneic hematopoietic stem cell transplantation in chronic lymphocytic leukemia
  • Venetoclax penetrates in cerebrospinal fluid and may be effective in chronic lymphocytic leukemia with central nervous system involvement
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