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High-risk pregnancies in Diamond-Blackfan anemia: a survey of 64 pregnancies from the French and German registries
L Faivre, J Meerpohl, L Da Costa, I Marie, C Nouvel, A Gnekow, C Bender-Gotze, F Bauters, B Coiffier, PY Peaud, P Rispal, A Berrebi, C Berger, M Flesch, P Sagot, B Varet, C Niemeyer, G Tchernia, T Leblanc
Haematologica January 2006 91: 530-533; doi:
L Faivre
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J Meerpohl
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L Da Costa
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I Marie
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C Nouvel
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A Gnekow
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C Bender-Gotze
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F Bauters
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B Coiffier
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PY Peaud
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P Rispal
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A Berrebi
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C Berger
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M Flesch
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P Sagot
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B Varet
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C Niemeyer
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G Tchernia
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T Leblanc
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Author Affiliations

  1. L Faivre,
  2. J Meerpohl,
  3. L Da Costa,
  4. I Marie,
  5. C Nouvel,
  6. A Gnekow,
  7. C Bender-Gotze,
  8. F Bauters,
  9. B Coiffier,
  10. PY Peaud,
  11. P Rispal,
  12. A Berrebi,
  13. C Berger,
  14. M Flesch,
  15. P Sagot,
  16. B Varet,
  17. C Niemeyer,
  18. G Tchernia and
  19. T Leblanc
  1. Centre de Genetique Medicale, Hopital d'Enfants, Dijon, France. laurence.faivre@chu-dijon.fr
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Abstract

We reviewed 64 pregnancies in 26 women with Diamond-Blackfan anemia (DBA) included in the French and German DBA registries. Complications were seen in 42 pregnancies (66%) and included abortion, pre-eclampsia, in utero fetal death, intrauterine growth retardation, retroplacental hematoma, pre-term delivery and fetal malformations. Of the 34 children (53%) born alive, 13 had DBA. No correlations were found between pregnancy outcome and features of either maternal or child DBA. Pregnancies in DBA-affected women are at high risk, especially for complications likely to be of vascular-placental origin. Careful monitoring with prevention of severe anemia and early introduction of aspirin is suggested.

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Vol 91 Issue 4

Haematologica: 91 (4)
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High-risk pregnancies in Diamond-Blackfan anemia: a survey of 64 pregnancies from the French and German registries
L Faivre, J Meerpohl, L Da Costa, I Marie, C Nouvel, A Gnekow, C Bender-Gotze, F Bauters, B Coiffier, PY Peaud, P Rispal, A Berrebi, C Berger, M Flesch, P Sagot, B Varet, C Niemeyer, G Tchernia, T Leblanc
Haematologica Jan 2006, 91 (4) 530-533;

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L Faivre, J Meerpohl, L Da Costa, I Marie, C Nouvel, A Gnekow, C Bender-Gotze, F Bauters, B Coiffier, PY Peaud, P Rispal, A Berrebi, C Berger, M Flesch, P Sagot, B Varet, C Niemeyer, G Tchernia, T Leblanc
Haematologica Jan 2006, 91 (4) 530-533;
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