Author Affiliations

  1. G Talamo,
  2. F Cavallo,
  3. M Zangari,
  4. B Barlogie,
  5. CK Lee,
  6. M Pineda-Roman,
  7. E Kiwan,
  8. S Krishna and
  9. G Tricot
  1. Myeloma Institute for Research and Therapy, Division of Gastroenterology, The University of Arkansas for Medical Sciences, 4301 West Markham Street/Slot 776, Little Rock, Arkansas 72205, USA.

Abstract

We report 24 cases of multiple myeloma (MM) with involvement of the gastrointestinal (GI) system. We found a strong association with high A lactate dehydrogenase levels, plasmablastic morphology, and A unfavorable karyotype. GI involvement at the time of initial diagnosis was much rarer than later in the course of the disease. The A median survival after diagnosis of GI involvement was 7 months. Among 13 patients treated with stem cell transplantation, the response rate was 92%, and median progression-free survival was 4 months. We conclude that MM involving the GI system is associated with adverse biological features and with short-lasting remissions, even after A high-dose chemotherapy.