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Table of Contents

June 30, 2008 ;  93 (7)

Editorials and Perspectives

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    Hereditary red cell disorders and malaria resistance
    Pierre M. Durand, Theresa L. Coetzer
    Haematologica July 2008 93: 961-963; doi:10.3324/haematol.13371
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    Familial erythrocytosis: molecular links to red blood cell control
    Melanie J. Percy, Frank S. Lee
    Haematologica July 2008 93: 963-967; doi:10.3324/haematol.13250
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    Myelodysplastic syndrome with isolated 5q deletion (5q- syndrome). A clonal stem cell disorder characterized by defective ribosome biogenesis
    Mario Cazzola
    Haematologica July 2008 93: 967-972; doi:10.3324/haematol.13377
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    Molecular pathophysiology of Philadelphia-negative myeloproliferative disorders: beyond JAK2 and MPL mutations
    Alessandro M. Vannucchi, Paola Guglielmelli
    Haematologica July 2008 93: 972-976; doi:10.3324/haematol.13266
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    Molecular characterization of acute myeloid leukemia
    Konstanze Döhner, Hartmut Döhner
    Haematologica July 2008 93: 976-982; doi:10.3324/haematol.13345
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    Gene expression signatures in follicular lymphoma: are they ready for the clinic?
    Nathalie A. Johnson, Randy D. Gascoyne
    Haematologica July 2008 93: 982-987; doi:10.3324/haematol.13326

Original Articles

Red Cell Disorders

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    Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males
    Isabelle Berthaut, Geoffroy Guignedoux, Frederique Kirsch-Noir, Vanina de Larouziere, Celia Ravel, Dora Bachir, Frédéric Galactéros, Pierre-Yves Ancel, Jean-Marie Kunstmann, Laurence Levy, Pierre Jouannet, Robert Girot, Jacqueline Mandelbaum
    Haematologica July 2008 93: 988-993; doi:10.3324/haematol.11515

Myelodysplastic Syndromes

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    Genome-wide analysis of copy number changes and loss of heterozygosity in myelodysplastic syndrome with del(5q) using high-density single nucleotide polymorphism arrays
    Li Wang, Carrie Fidler, Nandita Nadig, Aristoteles Giagounidis, Matteo G. Della Porta, Luca Malcovati, Sally Killick, Norbert Gattermann, Carlo Aul, Jacqueline Boultwood, James S. Wainscoat
    Haematologica July 2008 93: 994-1000; doi:10.3324/haematol.12603
    • Wang et al. - Supplementary Appendix
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    Fluorescence in situ hybridization improves the detection of 5q31 deletion in myelodysplastic syndromes without cytogenetic evidence of 5q-
    Mar Mallo, Leonor Arenillas, Blanca Espinet, Marta Salido, Jesús Mª Hernández, Eva Lumbreras, Mónica del Rey, Eva Arranz, Soraya Ramiro, Patricia Font, Olga González, Mónica Renedo, José Cervera, Esperanza Such, Guillermo F. Sanz, Elisa Luño, Carmen Sanzo, Miriam González, María José Calasanz, José Mayans, Carlos García-Ballesteros, Victoria Amigo, Rosa Collado, Isabel Oliver, Félix Carbonell, Encarna Bureo, Andrés Insunza, Lucrecia Yañez, María José Muruzabal, Elena Gómez-Beltrán, Rafael Andreu, Pilar León, Valle Gómez, Ángeles Sanz, Natalia Casasola, Esperanza Moreno, Adrián Alegre, María Luisa Martín, Carmen Pedro, Sergi Serrano, Lourdes Florensa, Francesc Solé
    Haematologica July 2008 93: 1001-1008; doi:10.3324/haematol.13012

Myeloproliferative Disorders

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    Aberrant expression of microRNA in polycythemia vera
    Hana Bruchova, Michaela Merkerova, Josef T. Prchal
    Haematologica July 2008 93: 1009-1016; doi:10.3324/haematol.12706
    • Bruchova et al. - Supplementary Appendix

Acute Myeloid Leukemia

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    Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia
    Francesco Lo-Coco, Antonio Cuneo, Fabrizio Pane, Daniela Cilloni, Daniela Diverio, Marco Mancini, Nicoletta Testoni, Antonella Bardi, Barbara Izzo, Niccolò Bolli, Roberta La Starza, Paola Fazi, Simona Iacobelli, Alfonso Piciocchi, Marco Vignetti, Sergio Amadori, Franco Mandelli, Pier Giuseppe Pelicci, Cristina Mecucci, Brunangelo Falini, Giuseppe Saglio, Giuseppe Saglio
    Haematologica July 2008 93: 1017-1024; doi:10.3324/haematol.12004
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    M4 acute myeloid leukemia: the role of eosinophilia and cytogenetics in treatment response and survival. The GIMEMA experience
    Alessandro Pulsoni, Simona Iacobelli, Massimo Bernardi, Marco Borgia, Andrea Camera, Nicola Cantore, Francesco Di Raimondo, Paola Fazi, Felicetto Ferrara, Franco Leoni, Vincenzo Liso, Marco Mancini, Filippo Marmont, Angela Matturro, Luca Maurillo, Lorella Melillo, Giovanna Meloni, Salvo Mirto, Giorgina Specchia, Caterina Giovanna Valentini, Adriano Venditti, Giuseppe Leone, Robin Foà, Franco Mandelli, Livio Pagano
    Haematologica July 2008 93: 1025-1032; doi:10.3324/haematol.11889

Malignant Lymphomas

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    Gene expression analysis provides a potential rationale for revising the histological grading of follicular lymphomas
    Pier Paolo Piccaluga, Andrea Califano, Ulf Klein, Claudio Agostinelli, Beatriz Bellosillo, Eva Gimeno, Sergi Serrano, Francisco Solè, Yonghui Zang, Brunangelo Falini, Pier Luigi Zinzani, Stefano A. Pileri
    Haematologica July 2008 93: 1033-1038; doi:10.3324/haematol.12754
    • Piccaluga et al. - Supplementary Appendix

Lymphoproliferative Disorders

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    The effect of FK506 on transforming growth factor β signaling and apoptosis in chronic lymphocytic leukemia B cells
    Simona Romano, Maria Mallardo, Federico Chiurazzi, Rita Bisogni, Anna D’Angelillo, Raffaele Liuzzi, Giovanna Compare, Maria Fiammetta Romano
    Haematologica July 2008 93: 1039-1048; doi:10.3324/haematol.12402

Multiple Myeloma

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    A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versus-myeloma effect
    Henk Rozemuller, Ellen van der Spek, Lijnie H. Bogers-Boer, Mieke C. Zwart, Vivienne Verweij, Maarten Emmelot, Richard W. Groen, Robbert Spaapen, Andries C. Bloem, Henk M. Lokhorst, Tuna Mutis, Anton C. Martens
    Haematologica July 2008 93: 1049-1057; doi:10.3324/haematol.12349

Transfusion Medicine

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    Granulocyte concentrates: prolonged functional capacity during storage in the presence of phenotypic changes
    Agata Drewniak, Jaap-Jan Boelens, Hans Vrielink, Anton T.J. Tool, Marrie C.A. Bruin, Marry van den Heuvel-Eibrink, Lynne Ball, Marianne D. van de Wetering, Dirk Roos, Taco W. Kuijpers
    Haematologica July 2008 93: 1058-1067; doi:10.3324/haematol.12489
    • Drewniak et al. - Supplementary Appendix

Brief Report

Erythrocytosis

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    A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis
    Maurizio Martini, Luciana Teofili, Tonia Cenci, Fiorina Giona, Lorenza Torti, Massimiliano Rea, Robin Foà, Giuseppe Leone, Luigi Maria Larocca
    Haematologica July 2008 93: 1068-1071; doi:10.3324/haematol.13210
    • Martini et al. - Supplementary Appendix
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    A study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor gene
    Maha Al-Sheikh, Elodie Mazurier, Betty Gardie, Nicole Casadevall, Frédéric Galactéros, Michel Goossens, Henri Wajcman, Claude Préhu, Valérie Ugo
    Haematologica July 2008 93: 1072-1075; doi:10.3324/haematol.12260

Acute Myeloid Leukemia

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    Molecular characterization of the MLL-SEPT6 fusion gene in acute myeloid leukemia: identification of novel fusion transcripts and cloning of genomic breakpoint junctions
    Nuno Cerveira, Francesca Micci, Joana Santos, Manuela Pinheiro, Cecília Correia, Susana Lisboa, Susana Bizarro, Lucília Norton, Anders Glomstein, Ann E. Åsberg, Sverre Heim, Manuel R. Teixeira
    Haematologica July 2008 93: 1076-1080; doi:10.3324/haematol.12594
    • Cerveira et al. - Supplementary Appendix

Lymphoproliferative Disorders

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    Transcriptional activation of the cardiac homeobox gene CSX1/NKX2-5 in a B-cell chronic lymphoproliferative disorder
    Xinying Su, Véronique Della-Valle, Eric Delabesse, Zahia Azgui, Roland Berger, Hélène Merle-Béral, Olivier A Bernard, Florence Nguyen-Khac
    Haematologica July 2008 93: 1081-1085; doi:10.3324/haematol.12595
    • Su et al. - Supplementary Appendix

Familial Hemophagocytic Lymphohistiocytosis

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    Mutations affecting mRNA splicing are the most common molecular defect in patients with familial hemophagocytic lymphohistiocytosis type 3
    Alessandra Santoro, Sonia Cannella, Antonino Trizzino, Giuseppa Bruno, Carmen De Fusco, Luigi D. Notarangelo, Daniela Pende, Gillian M. Griffiths, Maurizio Aricò
    Haematologica July 2008 93: 1086-1090; doi:10.3324/haematol.12622
    • Santoro et al. - Supplementary Appendix

Disorders of Hemostasis

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    Severe and moderate hemophilia A: identification of 38 new genetic alterations
    Pilar Casaña, Noelia Cabrera, Ana Rosa Cid, Saturnino Haya, Magdalena Beneyto, Carmen Espinós, Vicente Cortina, Maria Angeles Dasí, Josè Antonio Aznar
    Haematologica July 2008 93: 1091-1094; doi:10.3324/haematol.12344

Letters to the Editor

Thalassemia Syndromes

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    No evidence of cardiac iron in 20 never- or minimally-transfused patients with thalassemia intermedia
    Raffaella Origa, Susanna Barella, Giovanni Maria Argiolas, Patrizio Bina, Annalisa Agus, Renzo Galanello
    Haematologica July 2008 93: 1095-1096; doi:10.3324/haematol.12484

Hemoglobinopathies

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    Defective mRNA levels are responsible for a β-thalassemia phenotype associated with Hb Federico II, a novel hemoglobin variant [β-106 (G8) Leu→Val]
    Michela Grosso, Ilaria Palumbo, Emanuela Morelli, Stella Puzone, Raffaele Sessa, Paola Izzo
    Haematologica July 2008 93: 1096-1098; doi:10.3324/haematol.11722

Myeloproliferative Disorders

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    Oligoarray comparative genomic hybridization in polycythemia vera and essential thrombocythemia
    Ioana Borze, Satu Mustjoki, Eeva Juvonen, Sakari Knuutila
    Haematologica July 2008 93: 1098-1100; doi:10.3324/haematol.12547
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    Low-dose thalidomide in myelofibrosis
    Robert Weinkove, John T. Reilly, Mary Frances McMullin, Natasha J. Curtin, Deepti Radia, Claire N. Harrison
    Haematologica July 2008 93: 1100-1101; doi:10.3324/haematol.12416

Chronic Myeloid Leukemia

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    Increased cortical bone mineralization in imatinib treated patients with chronic myelogenous leukemia
    Sofia Jönsson, Bob Olsson, Claes Ohlsson, Mattias Lorentzon, Dan Mellström, Hans Wadenvik
    Haematologica July 2008 93: 1101-1103; doi:10.3324/haematol.12373
    • Jonsson et al. - Supplementary Appendix

Acute Myeloid Leukemia

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    RETRACTED: Heterogeneous promoter activity of the telomerase reverse transcriptase gene in individual acute myeloid leukemia cells defined by lentiviral reporter assay
    Seiichiro Kobayashi, Yasushi Soda, Yuansong Bai, Arinobu Tojo
    Haematologica July 2008 93: 1103-1105; doi:10.3324/haematol.12123
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    Expression of the nuclear oncogene Ski in patients with acute myeloid leukemia treated with all-trans retinoic acid
    Sabine Teichler, Richard F. Schlenk, Konstantin Strauch, Nicole M. Hagner, Markus Ritter, Andreas Neubauer
    Haematologica July 2008 93: 1105-1107; doi:10.3324/haematol.12003

Malignant Lymphomas

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    NOTCH2 mutations in marginal zone lymphoma
    Gunhild Trøen, Iwona Wlodarska, Abdirashid Warsame, Silvia Hernández Llodrà, Christiane De Wolf-Peeters, Jan Delabie
    Haematologica July 2008 93: 1107-1109; doi:10.3324/haematol.11635

Monoclonal Gammopathies

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    The IL6(-174G/C) polymorphism is a prognostic factor for survival after treatment initiation in Waldenström macroglobulinemia patients aged 65 years or less
    Stéphanie Poulain, Isabelle Dervite, Xavier Leleu, Valérie Coiteux, Patrick Duthilleul, Pierre Morel
    Haematologica July 2008 93: 1109-1111; doi:10.3324/haematol.12530

Chronic Lymphocytic Leukemia

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    The MDM2 –309 T/G promoter single nucleotide polymorphism does not alter disease characteristics in chronic lymphocytic leukemia
    Thorsten Zenz, Sonja Häbe, Axel Benner, Dirk Kienle, Hartmut Döhner, Stephan Stilgenbauer
    Haematologica July 2008 93: 1111-1113; doi:10.3324/haematol.12738
    • Zenz et al. - Supplementary Appendix

Platelets

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    A possible role for low-dose cyclosporine in refractory immune thrombocytopenic purpura
    Giovanni Emilia, Mario Luppi, Monica Morselli, Fabio Forghieri, Leonardo Potenza, Giuseppe Torelli
    Haematologica July 2008 93: 1113-1115; doi:10.3324/haematol.12741

Thrombosis

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    IgM anti-protein S antibodies as a risk factor for venous thrombosis
    Montserrat Borrell, Isabel Tirado, José Mateo, Artur Oliver, Amparo Santamaría, Jordi Fontcuberta
    Haematologica July 2008 93: 1115-1117; doi:10.3324/haematol.12575
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    Antiplatelet drugs and risk of venous thromboembolism: results from the EDITH case-control study
    Karine Lacut, Jantien van der Maaten, Grégoire Le Gal, Géraldine Cornily, Dominique Mottier, Emmanuel Oger
    Haematologica July 2008 93: 1117-1118; doi:10.3324/haematol.12331

Gaucher Disease

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    Persistent bone disease in adult type 1 Gaucher disease despite increasing doses of enzyme replacement therapy
    Maaike de Fost, Carel J.M. van Noesel, Johannes M.F.G. Aerts, Mario Maas, Ruud G. Pöll, Carla E.M. Hollak
    Haematologica July 2008 93: 1119-1120; doi:10.3324/haematol.12651

Online Only Articles

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    Comment to: The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement. Haematologica 2007; 92:1335-1342
    P Bertrand, C Maingonnat, P Ruminy, H Tilly, C Bastard
    Haematologica July 2008 93: e53; doi:10.3324/haematol.13190
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    Reply to: [Comment to: The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement. Haematologica 2007; 92:1335-1342
    Hervé Avet-Loiseau
    Haematologica July 2008 93: e54; doi:10.3324/haematol.13220
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    Comment to: Recombinant erythropoietin found in seized blood bags from sportsmen. Haematologica 2008;93:313–4
    Giuseppe Lippi, Massimo Franchini, Bengt Kayser
    Haematologica July 2008 93: e55; doi:10.3324/haematol.13179
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    Reply to: [Comment to: Recombinant erythropoietin found in seized blood bags from sportsmen. Haematologica 2008;93:313-4
    Joaquim Mallorqui, Jordi Segura, Carme de Bolòs, Ricardo Gutierrez-Gallegom, José A. Pascual
    Haematologica July 2008 93: e56; doi:10.3324/haematol.13234
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    Comment to: Secondary malignancies after treatment for indolent non-Hodgkin’s lymphoma: a 16-year follow-up study. Haematologica 2008; 93:398-403
    Ellen van der Spek, René van der Griend
    Haematologica July 2008 93: e57; doi:10.3324/haematol.13240
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    Reply to: [Comment to: Secondary malignancies after treatment for indolent non-Hodgkin’s lymphoma: a 16-year follow-up study. Haematologica 2008; 93:398-403
    S. Sacchi
    Haematologica July 2008 93: e58; doi:10.3324/haematol.13294
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In this issue

Haematologica: 93 (7)
  • Table of Contents
  • Table of Contents (PDF)
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  • Editorials and Perspectives
  • Original Articles
    • Red Cell Disorders
    • Myelodysplastic Syndromes
    • Myeloproliferative Disorders
    • Acute Myeloid Leukemia
    • Malignant Lymphomas
    • Lymphoproliferative Disorders
    • Multiple Myeloma
    • Transfusion Medicine
  • Brief Report
    • Erythrocytosis
    • Acute Myeloid Leukemia
    • Lymphoproliferative Disorders
    • Familial Hemophagocytic Lymphohistiocytosis
    • Disorders of Hemostasis
  • Letters to the Editor
    • Thalassemia Syndromes
    • Hemoglobinopathies
    • Myeloproliferative Disorders
    • Chronic Myeloid Leukemia
    • Acute Myeloid Leukemia
    • Malignant Lymphomas
    • Monoclonal Gammopathies
    • Chronic Lymphocytic Leukemia
    • Platelets
    • Thrombosis
    • Gaucher Disease
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