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Table of Contents

January 31, 2011 ;  96 (2)

Editorials and Perspectives

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    Clonal evolution in myelodysplastic syndromes with isolated del(5q): the importance of genetic monitoring
    Martin Jädersten, Aly Karsan
    Haematologica February 2011 96: 177-180; doi:10.3324/haematol.2010.038281
    • Disclosures
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    Myelodysplastic syndromes with bone marrow fibrosis
    Matteo Giovanni Della Porta, Luca Malcovati
    Haematologica February 2011 96: 180-183; doi:10.3324/haematol.2010.039875
    • Disclosures
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    Pathophysiology of thrombosis in myeloproliferative neoplasms
    Raffaele Landolfi, Leonardo Di Gennaro
    Haematologica February 2011 96: 183-186; doi:10.3324/haematol.2010.038299
    • Disclosures
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    Macrophages predict treatment outcome in Hodgkin’s lymphoma
    Christian Steidl, Pedro Farinha, Randy D. Gascoyne
    Haematologica February 2011 96: 186-189; doi:10.3324/haematol.2010.033316

Original Article

Hematopoiesis

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    The role of meis1 in primitive and definitive hematopoiesis during zebrafish development
    Ana Cvejic, Jovana Serbanovic-Canic, Derek L. Stemple, Willem H. Ouwehand
    Haematologica February 2011 96: 190-198; doi:10.3324/haematol.2010.027698
    • Disclosures and Contributions
    • Supplementary Appendix
    • Supplementary Movies

Iron Metabolism

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    Iron overload induces BMP6 expression in the liver but not in the duodenum
    Léon Kautz, Céline Besson-Fournier, Delphine Meynard, Chloé Latour, Marie-Paule Roth, Hélène Coppin
    Haematologica February 2011 96: 199-203; doi:10.3324/haematol.2010.031963
    • Disclosures and Contributions
    • Supplementary Appendix

Chronic Myeloid Leukemia

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    Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylate
    Serena Giuntoli, Michele Tanturli, Federico Di Gesualdo, Valentina Barbetti, Elisabetta Rovida, Persio Dello Sbarba
    Haematologica February 2011 96: 204-212; doi:10.3324/haematol.2010.029082
    • Disclosures and Contributions
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    OCT-1 function varies with cell lineage but is not influenced by BCR-ABL
    Jane R. Engler, Andrew C.W. Zannettino, Charles G. Bailey, John E.J. Rasko, Timothy P. Hughes, Deborah L. White
    Haematologica February 2011 96: 213-220; doi:10.3324/haematol.2010.033290
    • Disclosures and Contributions
    • Supplementary Appendix

Acute Myeloid Leukemia

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    Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia
    Brian V. Balgobind, Marry M. Van den Heuvel-Eibrink, Renee X. De Menezes, Dirk Reinhardt, Iris H.I.M. Hollink, Susan T.J.C.M. Arentsen-Peters, Elisabeth R. van Wering, Gertjan J.L. Kaspers, Jacqueline Cloos, Evelien S.J.M. de Bont, Jean-Michel Cayuela, Andre Baruchel, Claus Meyer, Rolf Marschalek, Jan Trka, Jan Stary, H. Berna Beverloo, Rob Pieters, C. Michel Zwaan, Monique L. den Boer
    Haematologica February 2011 96: 221-230; doi:10.3324/haematol.2010.029660
    • Balgobind et al. Supplementary Appendix
    • Disclosures and Contributions
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    Prognostic factors for intensive care unit admission, intensive care outcome, and post-intensive care survival in patients with de novo acute myeloid leukemia: a single center experience
    Peter Schellongowski, Thomas Staudinger, Michael Kundi, Klaus Laczika, Gottfried J. Locker, Andja Bojic, Oliver Robak, Valentin Fuhrmann, Ulrich Jäger, Peter Valent, Wolfgang R. Sperr
    Haematologica February 2011 96: 231-237; doi:10.3324/haematol.2010.031583
    • Disclosures and Contributions

Acute Lymphoblastic Leukemia

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    Liposomal cytarabine is effective and tolerable in the treatment of central nervous system relapse of acute lymphoblastic leukemia and very aggressive lymphoma
    Nicola Gökbuget, Christina-Maria Hartog, Renato Bassan, Heinz-Gerd Derigs, Herve Dombret, Richard Greil, Jesus-Maria Hernández-Rivas, Francoise Huguet, Tamara Intermesoli, Eric Jourdan, Christian Junghanss, Lothar Leimer, Maria-Jose Moreno, Albrecht Reichle, Josep Ribera, Matthias Schmid, Hubert Serve, Matthias Stelljes, Reingard Stuhlmann, Dieter Hoelzer
    Haematologica February 2011 96: 238-244; doi:10.3324/haematol.2010.028092
    • Disclosures and Contributions
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    A randomized study of pegylated liposomal doxorubicin versus continuous-infusion doxorubicin in elderly patients with acute lymphoblastic leukemia: the GRAALL-SA1 study
    Mathilde Hunault-Berger, Thibaut Leguay, Xavier Thomas, Ollivier Legrand, Françoise Huguet, Caroline Bonmati, Martine Escoffre-Barbe, Laurence Legros, Pascal Turlure, Patrice Chevallier, Fabrice Larosa, Frederic Garban, Oumedaly Reman, Philippe Rousselot, Nathalie Dhédin, André Delannoy, Marina Lafage-Pochitaloff, Marie Christine Béné, Norbert Ifrah, Hervé Dombret
    Haematologica February 2011 96: 245-252; doi:10.3324/haematol.2010.027862
    • Disclosures and Contributions
    • Supplementary Appendix

Malignant Lymphomas

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    β-catenin is constitutively active and increases STAT3 expression/activation in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
    Mona Anand, Raymond Lai, Pascal Gelebart
    Haematologica February 2011 96: 253-261; doi:10.3324/haematol.2010.027086
    • Disclosures and Contributions
    • Supplementary Appendix
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    Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children
    Ilske Oschlies, Birgit Burkhardt, Itziar Salaverria, Andreas Rosenwald, Emanuele S.G. d’Amore, Monika Szczepanowski, Karoline Koch, Martin L. Hansmann, Harald Stein, Peter Möller, Alfred Reiter, Martin Zimmermann, Angelo Rosolen, Reiner Siebert, Elaine S. Jaffe, Wolfram Klapper
    Haematologica February 2011 96: 262-268; doi:10.3324/haematol.2010.030809
    • Disclosures and Contributions
    • Supplementary Appendix
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    Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin’s lymphoma
    Peter Kamper, Knud Bendix, Stephen Hamilton-Dutoit, Bent Honoré, Jens R. Nyengaard, Francesco d’Amore
    Haematologica February 2011 96: 269-276; doi:10.3324/haematol.2010.031542
    • Disclosures and Contributions

Chronic Lymphocytic Leukemia

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    Differentiating chronic lymphocytic leukemia from monoclonal B-lymphocytosis according to clinical outcome: on behalf of the GIMEMA chronic lymphoproliferative diseases working group
    Stefano Molica, Francesca R. Mauro, Diana Giannarelli, Francesco Lauria, Agostino Cortelezzi, Maura Brugiatelli, Vincenzo Liso, Antonio Cuneo, Robin Foà
    Haematologica February 2011 96: 277-283; doi:10.3324/haematol.2010.030189
    • Disclosures and Contributions

Multiple Myeloma

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    Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab
    Michael. S. van der Veer, Michel de Weers, Berris van Kessel, Joost M. Bakker, Shulamiet Wittebol, Paul W.H.I. Parren, Henk M. Lokhorst, Tuna Mutis
    Haematologica February 2011 96: 284-290; doi:10.3324/haematol.2010.030759
    • Disclosures and Contributions
    • Supplementary Appendix

Stem Cell Transplantation

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    Allogeneic stem cell transplantation for myelodysplastic syndromes with bone marrow fibrosis
    Nicolaus Kröger, Tatjana Zabelina, Anja van Biezen, Ronald Brand, Dietger Niederwieser, Rodrigo Martino, Zi Yi Lim, Francesco Onida, Christoph Schmid, Laurent Garderet, Marie Robin, Michael van Gelder, Reinhard Marks, Argiris Symeonidis, Guido Kobbe, Theo de Witte
    Haematologica February 2011 96: 291-297; doi:10.3324/haematol.2010.031229
    • Disclosures and Contributions
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    Thymic recovery after allogeneic hematopoietic cell transplantation with non-myeloablative conditioning is limited to patients younger than 60 years of age
    Emilie Castermans, Muriel Hannon, Jacques Dutrieux, Stéphanie Humblet-Baron, Laurence Seidel, Rémi Cheynier, Evelyne Willems, André Gothot, Jean-François Vanbellinghen, Vincent Geenen, Brenda M. Sandmaier, Rainer Storb, Yves Beguin, Frédéric Baron
    Haematologica February 2011 96: 298-306; doi:10.3324/haematol.2010.029702
    • Disclosures and Contributions
    • Supplementary Appendix

Infectious Disorders

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    Repeated vaccination is required to optimize seroprotection against H1N1 in the immunocompromised host
    Hugues de Lavallade, Paula Garland, Takuya Sekine, Katja Hoschler, David Marin, Kate Stringaris, Eva Loucaides, Katherine Howe, Richard Szydlo, Ed Kanfer, Donald Macdonald, Peter Kelleher, Nichola Cooper, Ahmad Khoder, Ian H. Gabriel, Dragana Milojkovic, Jiri Pavlu, John M. Goldman, Jane F. Apperley, Katayoun Rezvani
    Haematologica February 2011 96: 307-314; doi:10.3324/haematol.2010.032664
    • Disclosures and Contributions
    • Supplementary Appendix

Brief Report

Myeloproliferative Neoplasms

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    Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3
    Tiziano Barbui, Alessandra Carobbio, Guido Finazzi, Alessandro M. Vannucchi, Giovanni Barosi, Elisabetta Antonioli, Paola Guglielmelli, Alessandro Pancrazzi, Silvia Salmoiraghi, Pio Zilio, Cosimo Ottomano, Roberto Marchioli, Ivan Cuccovillo, Barbara Bottazzi, Alberto Mantovani, Alessandro Rambaldi
    Haematologica February 2011 96: 315-318; doi:10.3324/haematol.2010.031070
    • Disclosures and Contributions
    • Supplementary Appendix

Myelodysplastic Syndromes

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    Cytogenetic follow-up by karyotyping and fluorescence in situ hybridization: implications for monitoring patients with myelodysplastic syndrome and deletion 5q treated with lenalidomide
    Gudrun Göhring, Aristoteles Giagounidis, Guntram Büsche, Winfried Hofmann, Hans Heinrich Kreipe, Pierre Fenaux, Eva Hellström-Lindberg, Brigitte Schlegelberger
    Haematologica February 2011 96: 319-322; doi:10.3324/haematol.2010.026658
    • Disclosures and Contributions

Lymphoproliferative Disorders

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    Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph
    Delphine Casabonne, Oscar Reina, Yolanda Benavente, Nikolaus Becker, Marc Maynadié, Lenka Foretová, Pierluigi Cocco, Anna González-Neira, Alexandra Nieters, Paolo Boffetta, Jaap M. Middeldorp, Silvia de Sanjose
    Haematologica February 2011 96: 323-327; doi:10.3324/haematol.2010.031161
    • Disclosures and Contributions
    • Supplementary Appendix

Multiple Myeloma

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    CD117 expression in gammopathies is associated with an altered maturation of the myeloid and lymphoid hematopoietic cell compartments and favorable disease features
    Martin Schmidt-Hieber, Martin Pérez-Andrés, Bruno Paiva, Juan Flores-Montero, Jose J. Perez, Norma C. Gutierrez, Maria-Belen Vidriales, Sergio Matarraz, Jesus F. San Miguel, Alberto Orfao
    Haematologica February 2011 96: 328-332; doi:10.3324/haematol.2010.031872
    • Disclosures and Contributions
    • Supplementary Appendix
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    A prospective evaluation of the biochemical, metabolic, hormonal and structural bone changes associated with bortezomib response in multiple myeloma patients
    Maurizio Zangari, Shmuel Yaccoby, Lisa Pappas, Federica Cavallo, Naveen Sanath Kumar, Subramanian Ranganathan, Larry J. Suva, J. Michael Gruenwald, Steven Kern, Fenghuang Zhan, Dixie Esseltine, Guido Tricot
    Haematologica February 2011 96: 333-336; doi:10.3324/haematol.2010.031302
    • Disclosures and Contributions

Infectious Disorders

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    Impact of invasive fungal disease on the chemotherapy schedule and event-free survival in acute leukemia patients who survived fungal disease: a case-control study
    Caroline Even, Sylvie Bastuji-Garin, Yosr Hicheri, Cécile Pautas, Francoise Botterel, Sébastien Maury, Ludovic Cabanne, Stéphane Bretagne, Catherine Cordonnier
    Haematologica February 2011 96: 337-341; doi:10.3324/haematol.2010.030825
    • Disclosures and Contributions

Letters to the Editor

Myeloproliferative Disorders

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    ETV6-ABL1-positive “chronic myeloid leukemia”: clinical and molecular response to tyrosine kinase inhibition
    Fabiana Perna, Omar Abdel-Wahab, Ross L. Levine, Suresh C. Jhanwar, Kazunori Imada, Stephen D. Nimer
    Haematologica February 2011 96: 342-343; doi:10.3324/haematol.2010.036673
    • Disclosures and Contributions

Malignant Lymphomas

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    Cytogenetically complex SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas
    Clare Bedwell, David Rowe, Deborah Moulton, Gail Jones, Nick Bown, Chris M. Bacon
    Haematologica February 2011 96: 343-346; doi:10.3324/haematol.2010.031484
    • Disclosures and Contributions

Online Only Articles

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    Deferiprone or deferasirox for cardiac siderosis in beta-thalassemia major
    Khaled M. Musallam, Ali T. Taher
    Haematologica February 2011 96: e5-e6; doi:10.3324/haematol.2010.036061
    • Disclosures and Contributions
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    Deferiprone or deferasirox for cardiac siderosis in β thalassemia major (reply)
    Alessia Pepe, Giuseppe Rossi, Antonella Meloni, Aurelio Maggio
    Haematologica February 2011 96: e7-e8; doi:10.3324/haematol.2010.039479
    • Disclosures and Contributions
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    Voriconazole as secondary antifungal prophylaxis in stem cell transplant recipients
    Catherine Cordonnier, Montserrat Rovira, Johan Maertens, Oliver A Cornely, Per Ljungman, Hermann Einsele
    Haematologica February 2011 96: e9-e10; doi:10.3324/haematol.2010.038463
    • Disclosures and Contributions
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    Voriconazole as secondary antifungal prophylaxis in stem cell transplant recipients (reply)
    Corrado Girmenia
    Haematologica February 2011 96: e11; doi:10.3324/haematol.2010.038810
    • Disclosures
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In this issue

Haematologica: 96 (2)
  • Table of Contents
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  • Editorials and Perspectives
  • Original Article
    • Hematopoiesis
    • Iron Metabolism
    • Chronic Myeloid Leukemia
    • Acute Myeloid Leukemia
    • Acute Lymphoblastic Leukemia
    • Malignant Lymphomas
    • Chronic Lymphocytic Leukemia
    • Multiple Myeloma
    • Stem Cell Transplantation
    • Infectious Disorders
  • Brief Report
    • Myeloproliferative Neoplasms
    • Myelodysplastic Syndromes
    • Lymphoproliferative Disorders
    • Multiple Myeloma
    • Infectious Disorders
  • Letters to the Editor
    • Myeloproliferative Disorders
    • Malignant Lymphomas
  • Online Only Articles

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