Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy alone
Daniel O. Persky, David Dornan, Bryan H. Goldman, Rita M. Braziel, Richard I. Fisher, Michael LeBlanc, David G. Maloney, Oliver W. Press, Thomas P. Miller, Lisa M. Rimsza
Haematologica June 2012 97: 937-942; doi:10.3324/haematol.2011.050419

Author Affiliations

  1. Daniel O. Persky1⇓,
  2. David Dornan2,
  3. Bryan H. Goldman3,
  4. Rita M. Braziel4,
  5. Richard I. Fisher5,
  6. Michael LeBlanc3,
  7. David G. Maloney6,
  8. Oliver W. Press6,
  9. Thomas P. Miller1 and
  10. Lisa M. Rimsza7
  1. 1Arizona Cancer Center, University of Arizona, Tucson, AZ
  2. 2Research Oncology Diagnostics, Genentech Inc., South San Francisco, CA
  3. 3Southwest Oncology Group Statistical Office, Seattle, WA
  4. 4Clinical Pathology, Oregon Health & Science University, Portland, OR
  5. 5James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY
  6. 6Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA
  7. 7Department of Pathology, University of Arizona, Tucson, AZ, USA
  1. Correspondence: Daniel O. Persky, MD, Arizona Cancer Center, University of Arizona, 1515 N Campbell Avenue, Tucson, AZ 85724-5024, USA. Phone: international +1.520.626-2218. Fax: international +1.520.626-2225. E-mail: dpersky{at}azcc.arizona.edu.
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Data supplements

ARTICLE FIGURES & DATA

Figures

  • Figure 1.
    Figure 1.

    (A) Overall survival (OS) by FCGR3A genotype for the chemotherapy only trial, S8809. (B) Overall survival (OS) by FCGR3A genotype for the chemotherapy + mAb trials, S9800 and S9911 (B). Kaplan-Meier curves, with follow up truncated at ten years. 158 F/F (unfavorable) genotype denoted by solid line; 158 V/F genotype denoted by dotted line; 158 V/V genotype denoted by dashed line.

  • Figure 2.
    Figure 2.

    (A) Progression-free survival (PFS) by FCGR3A 158 genotype for the chemotherapy only trial, S8809. (B) Progression-free survival (PFS) by FCGR3A 158 genotype for the chemotherapy + mAb trials, S9800 and S9911. Kaplan-Meier curves, with follow up truncated at ten years. 158 F/F (unfavorable) genotype denoted by solid line; 158 V/F genotype denoted by dotted line; 158 V/V genotype denoted by dashed line.

Tables

  • Table 1.

    Patient’s characteristics across clinical trials.

    Table 1.
  • Table 2.

    Fc gamma receptor 3A polymorphism studies in follicular lymphoma.

    Table 2.
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