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CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells

Department of Anatomy and Embryology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei, P.R. China;Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA;Department of Neurosurgery, Wuhan University Renmin Hospital, Wuhan, Hubei, P.R. China
Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA;Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, MA, USA
Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA;Department of Gynaecology, Wuhan University Renmin Hospital, Wuhan, Hubei, P.R. China
Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, MA, USA
Department of Computer Science, Metropolitan College, Boston University, MA, USA
Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA
Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA
Department of Molecular, Cell and Cancer Biology, University of Massachusetts School of Medicine, Worcester, MA, USA
Department of Molecular, Cell and Cancer Biology, University of Massachusetts School of Medicine, Worcester, MA, USA
Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, MA, USA
Department of Anatomy and Embryology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei, P.R. China
Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA;Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, MA, USA
Vol. 102 No. 1 (2017): January, 2017 https://doi.org/10.3324/haematol.2016.154013