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Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling

Mechanisms of Leukemogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany
Signaling to Chromatin Laboratory, Institute of Molecular Biology, Mainz, Germany
Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Mechanisms of Leukemogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany
Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Norway
Division of Hematology, University of Freiburg Medical Center, Germany
Division of Epigenetics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
Division of Epigenetics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
Department of Internal Medicine III, University of Ulm, Germany
Department of Internal Medicine III, University of Ulm, Germany
Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Mechanisms of Leukemogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany;Department of Internal Medicine III, University of Ulm, Germany
Vol. 101 No. 6 (2016): June, 2016 https://doi.org/10.3324/haematol.2015.138172