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Antileukemic activity and mechanism of action of the novel PI3K and histone deacetylase dual inhibitor CUDC-907 in acute myeloid leukemia

National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P.R. China
National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P.R. China
Department of Biological Sciences, Oakland University, Rochester, MI, USA
Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA;Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA;Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA;Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA;Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA;Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P.R. China
Division of Pediatric Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI, USA;Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P.R. China
Department of Pediatric Hematology and Oncology, The First Hospital of Jilin University, Changchun, P.R. China
Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA
Division of Pediatric Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI, USA;Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
Department of Hematology and Oncology, The First Hospital of Jilin University, Changchun, P.R. China
Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA;Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA;Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
Vol. 104 No. 11 (2019): November, 2019 https://doi.org/10.3324/haematol.2018.201343