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Trametinib inhibits RAS-mutant MLL-rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo

Pediatric Oncology/Hematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Vol. 103 No. 4 (2018): April, 2018 https://doi.org/10.3324/haematol.2017.174060