PT - JOURNAL ARTICLE AU - Ball, Brian AU - Stein, Eytan M. TI - Which are the most promising targets for minimal residual disease-directed therapy in acute myeloid leukemia prior to allogeneic stem cell transplant? AID - 10.3324/haematol.2018.208587 DP - 2019 Aug 01 TA - Haematologica PG - 1521--1531 VI - 104 IP - 8 4099 - http://www.haematologica.org/content/104/8/1521.short 4100 - http://www.haematologica.org/content/104/8/1521.full SO - Haematologica2019 Aug 01; 104 AB - Minimal residual disease has emerged as an important prognostic factor for relapse and survival in acute myeloid leukemia. Eradication of minimal residual disease may increase the number of patients with long-term survival; however, to date, strategies that specifically target minimal residual disease are limited. Consensus guidelines on minimal residual disease detection by immunophenotypic and molecular methods are an essential initial step for clinical trials evaluating minimal residual disease. Here, we review promising targets of minimal residual disease prior to allogeneic stem cell transplantation. Specifically, the focus of this review is on the rationale and clinical development of therapies targeting: oncogenic driver mutations, apoptosis, methylation, and leukemic immune targets. We review the progress made in the clinical development of therapies against each target and the challenges that lie ahead.