molecular pharmacology

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor
Aidan G. Gilmartin, Arthur Groy, Elizabeth R. Gore, Charity Atkins, Edward R. Long, Monica N. Montoute, Zining Wu, Wendy Halsey, Dean E. McNulty, Daniela Ennulat, Lourdes Rueda, Melissa Pappalardi, Ryan G. Kruger, Michael T. McCabe, Ali Raoof, Roger Butlin, Alexandra Stowell, Mark Cockerill, Ian Waddell, Donald Ogilvie, Juan Luengo, Allan Jordan, Andrew B. Benowitz

Haematologica Jun 2020, haematol.2020.248658; DOI: 10.3324/haematol.2020.248658
Targeting GLUT1 in acute myeloid leukemia to overcome cytarabine resistance.
Hannah Åbacka, Jesper S. Hansen, Peng Huang, Raminta Venskutonytė, Axel Hyrenius-Wittsten, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Filippo Minutolo, Anna K. Hagström-Andersson, Karin Lindkvist-Petersson

Haematologica Jun 2020, haematol.2020.246843; DOI: 10.3324/haematol.2020.246843
Human platelets are a source of collagen I
Anastasia Kyselova, Sven Zukunft, Deborah Puppe, Ilka Wittig, W. Alexander Mann, Imke Dornauf, Ingrid Fleming, Voahanginirina Randriamboavonjy

Haematologica Jun 2020, haematol.2020.255612; DOI: 10.3324/haematol.2020.255612
Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling
Amanda J. Unsworth, Alexander P. Bye, Tanya Sage, Renato S. Gaspar, Nathan Eaton, Caleb Drew, Alexander Stainer, Neline Kriek, Peter J. Volberding, James L. Hutchinson, Ryan Riley, Sarah Jones, Stuart J. Mundell, Weiguo Cui, Hervé Falet, Jonathan M. Gibbins

Haematologica May 2020, haematol.2019.223529; DOI: 10.3324/haematol.2019.223529
Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature
Sigal Tavor, Tali Shalit, Noa Chapal Ilani, Yoni Moskovitz, Nir Livnat, Yoram Groner, Haim Barr, Mark D. Minden, Alexander Plotnikov, Michael W. Deininger, Nathali Kaushansky, Liran I. Shlush

Haematologica May 2020, haematol.2019.240705; DOI: 10.3324/haematol.2019.240705
Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia
Aoli Wang, Chen Hu, Cheng Chen, Xiaofei Liang, Beilei Wang, Fengming Zou, Kailin Yu, Feng Li, Qingwang Liu, Ziping Qi, Junjie Wang, Wenliang Wang, Li Wang, Ellen L. Weisberg, Wenchao Wang, Lili Li, Jian Ge, Ruixiang Xia, Jing Liu, Qingsong Liu

Haematologica Apr 2020, haematol.2019.244186; DOI: 10.3324/haematol.2019.244186
Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia
Anuhar Chaturvedi, Charu Gupta, Razif Gabdoulline, Nora M. Borchert, Ramya Goparaju, Stefan Kaulfuss, Kerstin Görlich, Renate Schottmann, Basem Othman, Julia Welzenbach, Olaf Panknin, Markus Wagner, Robert Geffers, Arnold Ganser, Felicitas Thol, Michael Jeffers, Andrea Haegebarth, Michael Heuser

Haematologica Apr 2020, haematol.2019.236992; DOI: 10.3324/haematol.2019.236992
Low dose Btk inhibitors selectively block platelet activation by CLEC-2
Phillip L.R. Nicolson, Sophie H. Nock, Joshua Hinds, Lourdes Garcia-Quintanilla, Christopher W. Smith, Joana Campos, Alexander Brill, Jeremy A. Pike, Abdullah O. Khan, Natalie S. Poulter, Diedre M. Kavanagh, Stephanie Watson, Callum N. Watson, Hayley Clifford, Aarnoud P. Huissoon, Alice Y. Pollitt, Johannes A. Eble, Guy Pratt, Steve P. Watson, Craig E. Hughes

Haematologica Jan 2020, haematol.2019.218545; DOI: 10.3324/haematol.2019.218545
Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models
Eugenio Gaudio, Chiara Tarantelli, Filippo Spriano, Francesca Guidetti, Giulio Sartori, Roberta Bordone, Alberto J. Arribas, Luciano Cascione, Mario Bigioni, Giuseppe Merlino, Alessio Fiascarelli, Alessandro Bressan, Afua Adjeiwaa Mensah, Gaetanina Golino, Renzo Lucchini, Elena Bernasconi, Davide Rossi, Emanuele Zucca, Georg Stussi, Anastasios Stathis, Robert S. Boyd, Rachel L. Dusek, Arnima Bisht, Nickolas Attanasio, Christian Rohlff, Andrea Pellacani, Monica Binaschi, Francesco Bertoni

Haematologica Jan 2020, haematol.2019.227215; DOI: 10.3324/haematol.2019.227215
The novel L-nucleoside analogue, 5-Fluorotroxacitabine, displays potent efficacy against acute myeloid leukemia
Aniket Bankar, Thirushi Piyumika Siriwardena, Biljana Rizoska, Christina Rydergård, Helen Kylefjord, Vilma Rraklli, Anders Eneroth, Pedro Pinho, Stefan Norin, Johan Bylund, Sara Moses, Richard Bethell, Simon Kavanagh, Neil Maclean, Marcela Gronda, Xiaoming Wang, Rose Hurren, Mark D. Minden, Paul Targett-Adams, Aaron D. Schimmer, Mark Albertella

Haematologica Dec 2019, haematol.2019.226795; DOI: 10.3324/haematol.2019.226795

molecular pharmacology

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