molecular pharmacology

Variable readthrough responsiveness of nonsense mutations in hemophilia A
Lluis Martorell, Vicente Cortina, Rafael Parra, Jordi Barquinero, Francisco Vidal

Haematologica Jun 2019, haematol.2018.212118; DOI: 10.3324/haematol.2018.212118
A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease
James G. McArthur, Niels Svenstrup, Chunsheng Chen, Aurelie Fricot, Caroline Carvalho, Julia Nguyen, Phong Nguyen, Anna Prachikova, Fuad Abdulla, Gregory M. Vercellotti, Olivier Hermine, Dave Edwards, Jean-Antoine Ribeil, John D. Belcher, Thiago T. Maciel

Haematologica May 2019, haematol.2018.213462; DOI: 10.3324/haematol.2018.213462
Non-genotoxic MDM2 inhibition selectively induces pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells
Carmela Ciardullo, Erhan Aptullahoglu, Laura Woodhouse, Wei-Yu Lin, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec

Haematologica Apr 2019, haematol.2018.206631; DOI: 10.3324/haematol.2018.206631
Histone deacetylase inhibition in combination with MEK or BCL-2 inhibition in multiple myeloma
Vijay G. Ramakrishnan, Kevin C. Miller, Elaine P. Macon, Teresa K. Kimlinger, Jessica Haug, Sanjay Kumar, Wilson I. Gonsalves, S. Vincent Rajkumar, Shaji K. Kumar

Haematologica Mar 2019, haematol.2018.211110; DOI: 10.3324/haematol.2018.211110
Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity
Junyan Lu, Martin Böttcher, Tatjana Walther, Dimitrios Mougiakakos, Thorsten Zenz, Wolfgang Huber

Haematologica Feb 2019, haematol.2018.203067; DOI: 10.3324/haematol.2018.203067
MK2 is a therapeutic target for high-risk multiple myeloma
Chunyan Gu, Haibo Cheng, Hongbao Yang, Yong Bian, Yaohui Wang, Yifen Zhang, Michael Pisano, Gang Hu, Ye Yang

Haematologica Mar 2018, haematol.2017.182121; DOI: 10.3324/haematol.2017.182121
Identification of a germline F692L drug resistance variant in cis with Flt3-internal tandem duplication in knock-in mice
Oliver M. Dovey, Bin Chen, Annalisa Mupo, Mathias Friedrich, Carolyn S. Grove, Jonathan L. Cooper, Benjamin Lee, Ignacio Varela, Yue Huang, George S. Vassiliou

Haematologica Aug 2016, 101 (8) e328-e331; DOI: 10.3324/haematol.2016.146159
HA14-1, but not the BH3 mimetic ABT-737, causes Ca²⁺ dysregulation in platelets and human cell lines
Haidar Akl, Ilse Vandecaetsbeek, Giovanni Monaco, Alexandre Kauskot, Tomas Luyten, Kirsten Welkenhuyzen, Marc Hoylaerts, Humbert De Smedt, Jan B. Parys, Geert Bultynck

Haematologica Apr 2013, 98 (4) e49-e51; DOI: 10.3324/haematol.2012.080598