CURRENT ISSUE
December, 2025
No. 110 (12)

Landmark papers in Hematology

1

Editorials

7

Perspective Articles

1

Review Articles

1

Guidelines

1

Recognition, prevention, and management of adverse events associated with asparaginase/ pegaspargase treatment of acute lymphoblastic leukemia in adults: consensus of an expert panel (3278 Online Views)

Emily Curran, Marlise R. Luskin, Houda Alachkar, Ibrahim Aldoss, Patrick W. Burke, Ryan D. Cassaday, Seth E. Karol, Anthony J. Perissinotti, Cecilie Utke Rank, Kjeld Schmiegelow, Jonathan Webster, Dan Douer

https://doi.org/10.3324/haematol.2024.286744

Articles

13
Acute Lymphoblastic Leukemia

Acute Myeloid Leukemia

Different features of acute myeloid leukemia stem cell quantification in intensively treated patients (1993 Online Views)

Lok Lam Ngai, Tom Reuvekamp, Diana Hanekamp, Fleur Janssen, Laura Oudshoorn-van Marsbergen, Jannemieke Carbaat-Ham, Maaike A.M. Hofland, Mona M.H.E. Fayed, Angèle Kelder, Willemijn J. Scholten, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Dimitri A. Breems, Thomas Fischer, Bjørn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Arjan A. van de Loosdrecht, Johan A. Maertens, Markus G. Manz, Thomas Pabst, Jakob R. Passweg, Kimmo Porkka, Peter J.M. Valk, Patrycja Gradowska, Bob Löwenberg, Gert J. Ossenkoppele, David C. de Leeuw, Jacqueline Cloos

https://doi.org/10.3324/haematol.2024.287090

Cell Therapy & Immunotherapy

Randomized trial of anti-thymocyte globulin plus lowdose post-transplant cyclophosphamide to prevent graft-versus- host disease in haploidentical transplantation (1769 Online Views)

Zheng-Li Xu, Ting-Ting Han, Xiao-Lu Zhu, Jing Liu, Meng Lv, Yu-Qian Sun, Xiao-Dong Mo, Yi-Fei Cheng, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Yu Wang

https://doi.org/10.3324/haematol.2025.287504

Chronic Lymphocytic Leukemia

Novel PI3kδ inhibitor roginolisib synergizes with venetoclax in hematologic malignancies (2364 Online Views)

Binu Kandathilparambil Sasi, Chiara Tarantelli, Stephen Martindale, Elisa Civanelli, Eleonora Cannas, Giulio Sartori, Alberto J. Arribas, Stacey M. Fernandes, Samantha J. Shupe, John-Hanson Machado, Svitlana Tyekucheva, Yue Ren, Michael Lahn, Lars van der Veen, Giusy Di Conza, Francesco Bertoni, Jennifer R. Brown

https://doi.org/10.3324/haematol.2024.287180

Chronic Myeloid Leukemia

Optimizing olverembatinib dose in chronic phase chronic myeloid leukemia (2957 Online Views)

Xiaoshuai Zhang, Yunfan Yang, Bingcheng Liu, Xin Du, Xiaodong Wang, Huanling Zhu, Lu Yu, Zongru Li, Shasha Zhao, Linhua Yang, Yanping Ma, Li Meng, Yanqing Zhang, Guohui Li, Lijie Yang, Baohong Wang, Xuehong Ran, Jian Huang, Na Gao, Qin Wen, Yan Wen, Yuxia Zhao, Yu Zhu, Yanqiu Han, Zhenfang Liu, Xin Du, Jianyu Weng, Robert Peter Gale, Li Zhou, Yanli Zhang, Qian Jiang

https://doi.org/10.3324/haematol.2024.287116

Hematopoiesis

Myelodysplastic Syndromes

Bisecting GlcNAc expression by bone marrow stromal cells modulates TGF-β1-driven macrophage polarization in myeloid leukemias (1876 Online Views)

Jingjing Feng, Junjie Gou, Yi Wang, Wei Wei, Yihan Ma, Xueting Ren, Chongfu Zhao, Xiaoliang Cheng, Lei Lei, Zengqi Tan, Feng Guan, Xiang Li

https://doi.org/10.3324/haematol.2024.287091

Non-Hodgkin Lymphoma

Chemotherapy-free combination of ibrutinib and obinutuzumab for untreated advanced follicular lymphoma: results of a phase II study from the German Lymphoma Alliance (1661 Online Views)

Christian Schmidt, Gabriel Scheubeck, Vindi Jurinovic, Martin Sökler, Roswitha Forstpointner, Christian Buske, Andreas Viardot, Ulrich Keller, Ullrich Graeven, Reinhard Marks, Mathias Hänel, Rüdiger Liersch, Jan Dürig, Christiane Pott, Eva Hoster, Michael Unterhalt, Wolfgang Hiddemann

https://doi.org/10.3324/haematol.2024.287162

Plasma Cell Disorders

Revised renal stratification and progression models for predicting long-term renal outcomes in immunoglobulin light chain amyloidosis (1988 Online Views)

Muhammad Umaid Rauf, Steven Law, Marisa Santostefano, Philip N. Hawkins, Aviva Petrie, Francesco Cappelli, Federico Perfetto, Yousuf Razvi, Aldostefano Porcari, Sriram Ravichandran, Adam Ioannou, Joshua Bomsztyk, Alessia Argirò, Costanza Gaudio, Elisabetta Antonioli, Alessandro Barilaro, Marco Delsante, Vittorio Di Maso, Maria G. Chiappini, Olabisi Ogunbiyi, Oliver C. Cohen, Ana Martinez-Naharro, Carol Whelan, Helen J. Lachmann, Ashutosh D. Wechalekar, Federico Alberici, Marianna Fontana, Marco Allinovi, Julian D. Gillmore

https://doi.org/10.3324/haematol.2025.287703

Characterization, outcome and identification of prognostic factors for patients with systemic immunoglobulin lightchain amyloidosis requiring dialysis prior to initial anticlonal therapy (1561 Online Views)

Lilli S. Sester, Paolo Milani, Fenia Theodorakakou, Tobias Dittrich, Jörg Beimler, Fabian aus dem Siepen, Martin Zeier, Marc-Steffen Raab, Carsten Müller-Tidow, Efstathios Kastritis, Giovanni Palladini, Ute Hegenbart, Stefan O. Schönland

https://doi.org/10.3324/haematol.2025.287434

Comprehensive evaluation of disease characteristics and outcomes of patients with extramedullary multiple myeloma in the modern era (1804 Online Views)

Megan Broughton, Subodh Bhatta, Doshi Sonali, Naresh Bumma, Abdullah M. Khan, Srinivas Devarakonda, Elvira Umyarova, Don Benson, Ashley Rosko, Francesca Cottini

https://doi.org/10.3324/haematol.2025.287545

Extramedullary disease is associated with severe toxicities following B-cell maturation antigen CAR T-cell therapy in multiple myeloma (3058 Online Views)

Andrew J. Portuguese, Emily C. Liang, Jennifer J. Huang, Yein Jeon, Danai Dima, Rahul Banerjee, Mary Kwok, Kara I. Cicero, Alexandre V. Hirayama, Ryan Basom, Christy Khouderchah, Mazyar Shadman, Lawrence Fong, Andrew J. Cowan, Jordan Gauthier

https://doi.org/10.3324/haematol.2025.287985

Letters to the Editor

16

Atypical acute promyelocytic leukemia with tripartite fusion gene PML::RARG::LINE-L2a is resistant to ATRA but sensitive to arsenic-based therapy (1595 Online Views)

Sanyun Wu, Yalan Yu, Xiang Lin, Xiaosu Zhou, Yuanyuan Zhou, Ping Luo, Hui Shen, Jing He, Li Liu, Xiaoyan Liu, Dong Lei Zhang, Yanan Liu, Hui Xiao, Fuling Zhou, Hongxing Liu, Zhanglin Zhang

https://doi.org/10.3324/haematol.2025.287318

TET2 mutation does not impact the prognosis of adult acute myeloid leukemia patients receiving a hematopoietic stem cell transplantation in first remission: similar outcome following matched sibling and unrelated versus haploidentical donor transplants in a multi-center retrospective analysis from the Global Committee and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (1481 Online Views)

Lin Li, Yishan Ye, Jacques-Emmanuel Galimard, Myriam Labopin, Depei Wu, Jia Chen, Nicolaus Kröger, Jakob Passweg, Urpu Salmenniemi, Maija Itäla-Remes, Xavier Poiré, Matthias Eder, Johan Maertens, David Burns, Henrik Sengeloev, Gitte Olesen, Didier Blaise, Jürgen Finke, Alain Gadisseur, Ali Bazarbachi, Eolia Brissot, Arnon Nagler, Yi Luo, Jimin Shi, Mohamad Mohty, He Huang, Fabio Ciceri, Norbert Claude Gorin Sr.

https://doi.org/10.3324/haematol.2025.287326

Use of second-line and beyond maintenance therapies in adult patients with primary immune thrombocytopenia in Europe: a parallel study of six prospective multicenter national registries (1813 Online Views)

Guillaume Moulis, Frederick Chen, Giuseppe Carli, Waleed Ghanima, Karolin Trautmann-Grill, Thomas Stauch, Alexandra Schifferli, Haroon Miah, Manuela Rueter, Lisanna Ghiotto, Riccardo Tomasello, Annabell Georgi, Vickie McDonald, Francesco Zaja, Heidi Hassel Pettersen, Thomas Kühne, Maria Luisa Lozano, Tomás José González-López, Drew Provan, Marc Michel, Nichola Cooper, Francesco Rodeghiero

https://doi.org/10.3324/haematol.2025.287408

Radiopsy: a prospective observational study on quantitative multiparametric whole-body magnetic resonance imaging to discriminate between smoldering and multiple myeloma (1487 Online Views)

Giacomo Feliciani, Emiliano Loi, Elena Amadori, Eleonora Antognoni, Andrea Prochowski Iamurri, Danila Diano, Daniele Bruno, Arrigo Cattabriga, Paola Caroli, Matteo Marchesini, Davide Bezzi, Delia Cangini, Federica Matteucci, Domenico Barone, Davide Nappi, Gerardo Musuraca, Michela Ceccolini, Sonia Ronconi, Irene Azzali, Giovanni Martinelli, Lorenzo Stefano Maffioli, Nicola Normanno, Anna Sarnelli, Alice Rossi, Claudio Cerchione

https://doi.org/10.3324/haematol.2025.287563

A retrospective study of isatuximab-pomalidomidedexamethasone in relapsed/refractory systemic AL amyloidosis (1583 Online Views)

Sargam Rachit Vohra, Sriram Ravichandran, Darren Foard, Ana Martinez-Naharro, Lucia Venneri, Marianna Fontana, Carol J. Whelan, Philip N. Hawkins, Julian Gillmore, Helen J. Lachmann, Shameem Mahmood, Ashutosh D. Wechalekar

https://doi.org/10.3324/haematol.2025.287664

Oral administration of a liquid containing nitrous oxide abolishes vaso-occlusive pain in mice with sickle cell disease (1417 Online Views)

Ana Oddo, Fuad Abdulla, Annabelle Herold, Kathy Tang, Viacheslav Viatchenko-Karpinski, Iryna A. Khasabova, Sergey G. Khasabov, Mark Young, John D. Belcher, Gregory M. Vercellotti, Donald A. Simone

https://doi.org/10.3324/haematol.2025.287789

Unveiling platelet aging with progressive β-galactose exposure as a signature of platelet senescence in humans and mice (1509 Online Views)

Catherine Angénieux, Thomas Nipoti, Gabriel Rojas-Jiménez, Mélanie Daniel, Frédéric Adam, Annabelle Dupont, Blandine Maître, Alexandre Kauskot

https://doi.org/10.3324/haematol.2025.287812

PTPN11 mutations define a rare but highly adverse subset of myelodysplastic syndromes (1435 Online Views)

Alexandre Bazinet, Alex Bataller, Guillermo Montalban-Bravo, Kelly Chien, Koji Sasaki, Wei Ying Jen, Mahesh Swaminathan, Tapan Kadia, Courtney DiNardo, Farhad Ravandi, Guillermo Garcia-Manero, Hagop Kantarjian

https://doi.org/10.3324/haematol.2025.287874

Lower-intensity chemo-immunotherapy with cladribine, low-dose cytarabine, venetoclax and blinatumomab produces high response rates in patients with BCR::ABL1-negative B-cell/myeloid mixed phenotype acute leukemia (1558 Online Views)

Roberta S. Azevedo, Wei-Ying Jen, Danielle Hammond, Fadi G. Haddad, Alexis Geppner, Ghayas C. Issa, Koji Sasaki, Jayastu Senapati, Elias Jabbour, Farhad Ravandi, Hagop Kantarjian, Tapan M. Kadia

https://doi.org/10.3324/haematol.2025.287932

Optical genome mapping reveals complex cytogenetic abnormalities in multiple myeloma (1577 Online Views)

Jorge A. Palacios, Mónica Bernal, Jose R. Vílchez, Pilar Garrido, Pilar Jiménez, Juan F. Gutiérrez-Bautista, María C. Barrera-Aguilera, Lucía Ballesta, Teresa Rodríguez, María J. Olivares-Durán, Francisco Ruiz-Cabello

https://doi.org/10.3324/haematol.2025.288008

Minimal residual disease status predicts outcomes in patients with follicular lymphoma treated with chemoimmunotherapy on the SWOG S0016 trial (1643 Online Views)

Alexey V. Danilov, Hongli Li, Mazyar Shadman, Lisa Rimsza, Ahmad Zebari, Sonali M. Smith, Michael LeBlanc, Jonathan W. Friedberg, Christopher Carlson, Joo Y. Song

https://doi.org/10.3324/haematol.2025.288057

Fecal microbiota transplantation for decolonization from multidrug-resistant bacteria in pediatric allogeneic hematopoietic stem cell transplantation recipients: a retrospective real-world data study (1571 Online Views)

Riccardo Masetti, Giovanni Barbara, Edoardo Muratore, Giovanni Marasco, Cesare Cremon, Antonella Marangoni, Patrizia Brigidi, Lorenza Putignani, Giulia Angelino, Francesco Quagliarella, Federica Galaverna, Davide Leardini, Tiziana Lazzarotto, Maria Gabelli, Edoardo Savarino, Marco Zecca, Maura Faraci, Arcangelo Prete, Alessandra Biffi, Franco Locatelli, Pietro Merli

https://doi.org/10.3324/haematol.2025.288067

Treatment approaches and clinical outcomes in primary colorectal MALT lymphoma: a single-institution retrospective study of 66 patients (1462 Online Views)

Suheil Albert Atallah-Yunes, Matthew J. Rees, Thomas M. Habermann, Yucai Wang, Javier Munoz, Madiha Iqbal, Jose C. Villasboas, Ellen D. McPhail, Thomas E. Witzig, Stephen M. Ansell, Grzegorz S. Nowakowski

https://doi.org/10.3324/haematol.2025.288145

Case Reports

4

Don’t lose sight: rare extramedullary involvement of myeloid/lymphoid neoplasm with ETV6:ABL1 translocation in blast phase (1311 Online Views)

Neta Sternbach, Omer Y. Bialer, Alon Rozental, Adi Shacham-Abulafia, Shiri Yacobson, Reut T. Matar, Adam Sultan, Pia Raanani, Ofir Wolach

https://doi.org/10.3324/haematol.2025.287980

Treatment-relevant misdiagnosis of autoimmune myelofibrosis (886 Online Views)

Naseema Gangat, Kaaren K. Reichard, Attilio Orazi, David S. Viswanatha, Curtis A. Hanson, Ayalew Tefferi

https://doi.org/10.3324/haematol.2025.288638

Comments

2

Erratum

2

Erratum to: “Chemotherapy-free combination of ibrutinib and obinutuzumab for untreated advanced follicular lymphoma: results of a phase II study from the German Lymphoma Alliance” (64 Online Views)

Christian Schmidt, Gabriel Scheubeck, Vindi Jurinovic, Martin Sökler, Roswitha Forstpointner, Christian Buske, Andreas Viardot, Ulrich Keller, Ullrich Graeven, Reinhard Marks, Mathias Hänel, Rüdiger Liersch, Jan Dürig, Christiane Pott, Eva Hoster, Michael Unterhalt, Wolfgang Hiddemann

https://doi.org/10.3324/haematol.2025.288659

Erratum to: “Consistent clinical factor VIII equivalency is unlikely for non-factor therapies in hemophilic mice” (81 Online Views)

Thibaud Sefiane, Geneviève McCluskey, Marie Clavel, Hortense Maynadié, Ivan Peyron, Tovo David, Camille Brochier, François Saller, Mariem Khamari, Cécile V. Denis, Olivier D. Christophe, Peter J. Lenting, Vincent Muczynski, Caterina Casari

https://doi.org/10.3324/haematol.2025.289135