Early view

Jan 13, 2022

Editorials
Article

First-line treatment of chronic lymphocytic leukemia with ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab: final analysis of the randomized, phase 3 iLLUMINATE trial (195 Online Views)

Carol Moreno, Richard Greil, Fatih Demirkan, Alessandra Tedeschi, Bertrand Anz, Loree Larratt, Martin Simkovic, Jan Novak, Vladimir Strugov, Devinder Gill, John G. Gribben, Kevin Kwei, Sandra Dai, Emily Hsu, James P. Dean, Ian W. Flinn

https://doi.org/10.3324/haematol.2021.279012

Editorials

Editorials
Article

Clinical relevance of proteomic profiling in de novo pediatric acute myeloid leukemia: a Children’s Oncology Group study (140 Online Views)

Fieke W. Hoff, Anneke D. van Dijk, Yihua Qiu, Chenyue W. Hu, Rhonda E. Ries, Andrew Ligeralde, Gaye N. Jenkins, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Amina A. Qutub, Eveline S.J.M. de Bont, Terzah M. Horton, Steven M. Kornblau

https://doi.org/10.3324/haematol.2021.279672

Articles

Sorting Nexin 24 is required for α-granule biogenesis and cargo delivery in megakaryocytes (75 Online Views)

Joanne Lacey, Simon J. Webster, Paul R. Heath, Chris J. Hill, Lucinda Nicholson-Goult, Bart E. Wagner, Abdullah O. Khan, Neil V. Morgan, Michael Makris, Martina E. Daly

https://doi.org/10.3324/haematol.2021.279636

Oncogenic TYK2P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade (105 Online Views)

Katharina Woess, Sabine Macho-Maschler, Dorette S. van Ingen Schenau, Miriam Butler, Caroline Lassnig, Daniel Valcanover, Andrea Poelzl, Katrin Meissl, Barbara Maurer, Tania Brandstoetter, Claus Vogl, Anna Koren, Stefan Kubicek, Anna Orlova, Richard Moriggl, Birgit Strobl, Veronika Sexl, Frank N. van Leeuwen, Roland P. Kuiper, Mathias Mueller

https://doi.org/10.3324/haematol.2021.279848

Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS (272 Online Views)

Cho Mar Myint Wai, Shangying Chen, The Phyu, Shuangyi Fan, Sai Mun Leong, Wenning Zheng, Louis Ching Yi Low, Shoa-Nian Choo, Chi-Kuen Lee, Tae-Hoon Chung, Kenneth Hon Kim Ban, Soumita Ghosh, Stefanus Lie, Seiichi Kato, Shigeo Nakamura, Emiko Takahashi, Young-Hyeh Ko, Joseph D. Khoury, Shih-Sung Chuang, Rex K.H. Au-Yeung, Soo-Yong Tan, Soon-Thye Lim, Choon-Kiat Ong, Yong-Howe Ho, Li Mei Poon, Sanjay de Mel, Anand D. Jeyasekharan, Wee-Joo Chng, Franziska Otto, Leticia Quintanilla-Martinez, Federica Zanardi, Fabio Iannelli, Claudio Tripodo, Jason J. Pitt, Siok-Bian Ng

https://doi.org/10.3324/haematol.2021.280003

Letters to the Editor

Daratumumab with or without chemotherapy in relapsed and refractory acute lymphoblastic leukemia. A retrospective observational Campus Acute Lymphoblastic Leukemia study (81 Online Views)

Marco Cerrano, Massimiliano Bonifacio, Matteo Olivi, Antonio Curti, Michele Malagola, Michelina Dargenio, Anna Maria Scattolin, Cristina Papayannidis, Fabio Forghieri, Carmela Gurrieri, Ilaria Tanasi, Patrizia Zappasodi, Roberta La Starza, Nicola Stefano Fracchiolla, Patrizia Chiusolo, Luisa Giaccone, Maria Ilaria Del Principe, Fabio Giglio, Marzia Defina, Claudio Favre, Carmelo Rizzari, Barbara Castella, Giovanni Pizzolo, Felicetto Ferrara, Sabina Chiaretti, Robin Foà

https://doi.org/10.3324/haematol.2021.279851

Jan 6, 2022

Letters to the Editor

Conventional interferon-α2b versus hydroxyurea for newly-diagnosed patients with polycythemia vera in real world: a retrospective study based on 286 patients from a single center (121 Online Views)

Dan Liu, Zefeng Xu, Peihong Zhang, Tiejun Qin, Xiujuan Sun, Shiqiang Qu, Lijuan Pan, Jiao Ma, Wenyu Cai, Jinqin Liu, Huijun Wang, Qi Sun, Zhongxun Shi, Huijun Huang, Gang Huang, Robert Peter Gale, Bing Li, Raajit K. Rampal, Zhijian Xiao

https://doi.org/10.3324/haematol.2021.280080

Dec 30, 2021

Editorials
Letter to the Editor

Outcomes of refractory or relapsed Hodgkin lymphoma patients with post-autologous stem cell transplantation brentuximab vedotin maintenance: a French multicenter observational cohort study (236 Online Views)

Amira Marouf, Anne Segolene Cottereau, Salim Kanoun, Paul Deschamps, Michel Meignan, Patricia Franchi, David Sibon, Clara Antoine, Thomas Gastinne, Cecile Borel, Mohammad Hammoud, Guillaume Sicard, Romane Gille, Doriane Cavalieri, Aspasia Stamatoullas, Lauriane Filliatre-Clement, Julien Lazarovici, Adrien Chauchet, Luc-Matthieu Fornecker, Sandy Amorin, Mathieu Rocquet, Nicole Raus, Barbara Burroni, Marie Therese Rubio, Didier Bouscary, Philippe Quittet, Rene Olivier Casasnovas, Pauline Brice, Herve Ghesquieres, Jérôme Tamburini, Benedicte Deau

https://doi.org/10.3324/haematol.2021.279564

Case Reports

Kikuchi-Fujimoto disease associated with hemophagocytic lymphohistiocytosis following the BNT162b2 mRNA COVID-19 vaccination (164 Online Views)

Giovanni Caocci, Daniela Fanni, Mariagrazia Porru, Marianna Greco, Sonia Nemolato, Davide Firinu, Gavino Faa, Angelo Scuteri, Giorgio La Nasa

https://doi.org/10.3324/haematol.2021.280239

Platelet-activating anti-PF4 antibodies mimicking VITT antibodies in an unvaccinated patient with monoclonal gammopathy (103 Online Views)

Andreas Greinacher, Florian Langer, Linda Schonborn, Thomas Thiele, Munif Haddad, Thomas Renne, Jerome Rollin, Yves Gruel, Theodore E. Warkentin

https://doi.org/10.3324/haematol.2021.280366

Dec 23, 2021

Articles

Rational drug combinations with CDK4/6 inhibitors in acute lymphoblastic Leukemia (382 Online Views)

Karen L. Bride, Hai Hu, Anastasia Tikhonova, Tori J. Fuller, Tiffaney L. Vincent, Rawan Shraim, Marilyn M. Li, William L. Carroll, Elizabeth A. Raetz, Iannis Aifantis, David T. Teachey

https://doi.org/10.3324/haematol.2021.279410

Letters to the Editor

Effect of PAS-C on short-term cold-stored platelets in vitro and in vivo (57 Online Views)

S. Lawrence Bailey, Lydia Y. Fang, Lynda Fitzpatrick, Daire Byrne, Esther Pellham, Moritz Stolla

https://doi.org/10.3324/haematol.2021.279865

Phase 1b dose-escalation study of the selective, noncovalent, reversible Bruton’s tyrosine kinase inhibitor vecabrutinib in B-cell malignancies (122 Online Views)

John N. Allan, Javier Pinilla-Ibarz, Douglas E. Gladstone, Krish Patel, Jeff P. Sharman, William G. Wierda, Michael Y. Choi, Susan M. O’Brien, Mazyar Shadman, Matthew S. Davids, John M. Pagel, Habte A. Yimer, Renee Ward, Gary Acton, Pietro Taverna, Daniel L. Combs, Judith A. Fox, Richard R. Furman, Jennifer R. Brown

https://doi.org/10.3324/haematol.2021.280061

Case Reports

Dec 16, 2021

Articles

Antibody response after vaccination against SARS-CoV-2 in adults with haematological malignancies: a systematic review and meta-analysis (1316 Online Views)

Nico Gagelmann, Francesco Passamonti, Christine Wolschke, Radwan Massoud, Christian Niederwieser, Raissa Adjallé, Barbara Mora, Francis Ayuk, Nicolaus Kröger

https://doi.org/10.3324/haematol.2021.280163

Letters to the Editor

Loss of 5-hydroxymethylcytosine expression is nearuniversal in B-cell lymphomas with variable mutations in epigenetic regulators (80 Online Views)

Kevin S. Tanager, Jovian Yu, Brian C-H Chiu, Timothy C. Carll, Alexandra H. Tatarian, Peter Riedell, Sonali Smith, Justin Kline, Girish Venkataraman

https://doi.org/10.3324/haematol.2021.279648

Case Reports

VEXAS syndrome in a female patient with constitutional 45,X (Turner syndrome) (249 Online Views)

Ryan J. Stubbins, Eric McGinnis, Bhupinder Johal, Luke YC Chen, Lorena Wilson, Daniela Ospina Cardona, Thomas J. Nevill

https://doi.org/10.3324/haematol.2021.280238

Dec 9, 2021

Letters to the Editor

Early testicular maturation is sensitive to depletion of spermatogonial pool in sickle cell disease (201 Online Views)

Klara M. Benninghoven-Frey, Nina Neuhaus, Atte K. Lahtinen, Claudia Krallmann, Joana M.D. Portela, Andrea Jarisch, Verena Nordhoff, Armin Soave, Hajar A.M. Ba Omar, Mikael Sundin, Cecilia Langenskiöld, Sabine Kliesch, Jan-Bernd Stukenborg, Kirsi Jahnukainen

https://doi.org/10.3324/haematol.2021.279253

Dec 2, 2021

Articles

The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements (232 Online Views)

Sarah Grasedieck, Ariene Cabantog, Liam MacPhee, Junbum Im, Christoph Ruess, Burcu Demir, Nadine Sperb, Frank G. Rücker, Konstanze Döhner, Tobias Herold, Jonathan R. Pollack, Lars Bullinger, Arefeh Rouhi, Florian Kuchenbauer

https://doi.org/10.3324/haematol.2021.276048

Letters to the Editor

A phase I study of the fully human, fragment crystallizable-engineered, anti-CD-33 monoclonal antibody BI 836858 in patients with previously-treated acute myeloid leukemia (197 Online Views)

Sumithira Vasu, Jessica K. Altman, Geoffrey L. Uy, Martin S. Tallman, Ivana Gojo, Gerard Lozanski, Ute Burkard, Annika Osswald, Pamela James, Björn Rüter, William Blum

https://doi.org/10.3324/haematol.2020.274118

Biallelic CXCR2 loss-of-function mutations define a distinct congenital neutropenia entity (258 Online Views)

Viviana Marin-Esteban, Jenny Youn, Blandine Beaupain, Agnieszka Jaracz-Ros, Vincent Barlogis, Odile Fenneteau, Thierry Leblanc, Florence Bellanger, Philippe Pellet, Julien Buratti, Hélène Lapillonne, Françoise Bachelerie, Jean Donadieu, Christine Bellanné-Chantelot

https://doi.org/10.3324/haematol.2021.279254

Guideline for management of non-Down syndrome neonates with a myeloproliferative disease on behalf of the I-BFM AML Study Group and EWOG-MDS (353 Online Views)

Eline J.M. Bertrums, C. Michel Zwaan, Daisuke Hasegawa, Valerie de Haas, Dirk N. Reinhardt, Franco Locatelli, Barbara de Moerloose, Michael Dworzak, Arjan Buijs, Petr Smisek, Alexandra Kolenova, Cornelis Jan Pronk, Jan-Henning Klusmann, Ana Carboné, Alina Ferster, Evangelia Antoniou, Soheil Meshinchi, Susana C. Raimondi, Charlotte M. Niemeyer, Henrik Hasle, Marry M. van den Heuvel-Eibrink, Bianca F. Goemans

https://doi.org/10.3324/haematol.2021.279507

Dissociated humoral and cellular immune responses after a three-dose schema of BNT162b2 vaccine in patients receiving anti-CD20 monoclonal antibody maintenance treatment for B-cell lymphomas (184 Online Views)

Sophie Candon, Veronique Lemee, Emilie Leveque, Pascaline Etancelin, Cedric Paquin, Marion Carette, Nathalie Contentin, Victor Bobee, Mustafa Alani, Nathalie Cardinael, Stephane Lepretre, Vincent Camus, Florian Bouclet, Edwige Boulet, Anne-Lise Menard, Helene Lanic, Aspasia Stamatoullas, Emilie Lemasle, Louis-Ferdinand Pepin, Doriane Richard, Sydney Dubois, Herve Tilly, Alain Dalleac, Jean-Christophe Plantier, Manuel Etienne, Fabrice Jardin

https://doi.org/10.3324/haematol.2021.280139

Nov 25, 2021

Editorials
Letter to the Editor

Editorials
Article

The von Willebrand Factor A-1 domain binding aptamer BT200 elevates plasma levels of VWF and Factor VIII: a first-in-human trial (274 Online Views)

Katarina D. Kovacevic, Jürgen Grafeneder, Christian Schörgenhofer, Georg Gelbenegger, Gloria Gager, Christa Firbas, Peter Quehenberger, Petra Jilma-Stohlawetz, Andrea Bileck, Shuhao Zhu, James C. Gilbert, Martin Beliveau, Bernd Jilma, Ulla Derhaschnig

https://doi.org/10.3324/haematol.2021.279948

Nov 18, 2021

Editorials
Letter to the Editor

A third anti-SARS-Cov2 mRNA dose does not overcome the pejorative impact of anti-CD20 therapy and/or low immunoglobulin levels in patients with lymphoma or chronic lymphocytic leukemia (315 Online Views)

Milena Kohn, Marc Delord, Maureen Chbat, Amina Guemriche, Fatiha Merabet, Anne-Laure Roupie, Naelle Lombion, Hassan Farhat, Thomas Longval, Aurélie Cabannes-Hamy, Juliette Lambert, Stéphanie Marque-Juillet, Victoria Raggueneau, Jennifer Osman, Marc Spentchian, Sophie Rigaudeau, Philippe Rousselot, Caroline Besson

https://doi.org/10.3324/haematol.2021.280026

Articles

Genetic and genomic analysis of acute lymphoblastic leukaemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials (635 Online Views)

Thomas Creasey, Emilio Barretta, Sarra L. Ryan, Ellie Butler, Amy A. Kirkwood, Daniel Leongamornlert, Elli Papaemmanuil, Pip Patrick, Laura Clifton-Hadley, Bela Patel, Tobias Menne, Andrew K. McMillan, Christine J. Harrison, Clare J. Rowntree, Nick Morley, David I. Marks, Adele K. Fielding, Anthony V. Moorman

https://doi.org/10.3324/haematol.2021.279177

Mutational landscape of high-grade B-cell lymphoma with MYC-, BCL2 and/or BCL6 rearrangements characterized by whole-exome sequencing (557 Online Views)

Axel Künstner, Hanno M. Witte, Jörg Riedl, Veronica Bernard, Stephanie Stölting, Hartmut Merz, Vito Olschewski, Wolfgang Peter, Julius Ketzer, Yannik Busch, Peter Trojok, Nikolas von Bubnoff, Hauke Busch, Alfred C. Feller, Niklas Gebauer

https://doi.org/10.3324/haematol.2021.279631

Letters to the Editor

Mechanical unloading aggravates bone destruction and tumor expansion in myeloma (272 Online Views)

Kotaro Tanimoto, Masahiro Hiasa, Hirofumi Tenshin, Jumpei Teramachi, Asuka Oda, Takeshi Harada, Yoshiki Higa, Kimiko Sogabe, Masahiro Oura, Ryohei Sumitani, Tomoyo Hara, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka, Masahiro Abe

https://doi.org/10.3324/haematol.2021.278295

GNE-related thrombocytopenia: evidence for a mutational hotspot in the ADP/substrate domain of the GNE bifunctional enzyme (342 Online Views)

Roberta Bottega, Antonio Marzollo, Maddalena Marinoni, Emmanouil Athanasakis, Ilaria Persico, Anna Monica Bianco, Michela Faleschini, Erica Valencic, Daniela Simoncini, Linda Rossini, Fabio Corsolini, Martina La Bianca, Giuseppe Robustelli, Maria Gabelli, Massimo Agosti, Alessandra Biffi, Paolo Grotto, Valeria Bozzi, Patrizia Noris, Alberto B. Burlina, Adamo Pio d'Adamo, Alberto Tommasini, Flavio Faletra, Annalisa Pastore, Anna Savoia

https://doi.org/10.3324/haematol.2021.279689

Comments

Nov 11, 2021

Editorials
Article

Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy (414 Online Views)

Jana Ihlow, Sophia Gross, Leonie Busack, Anne Flörcken, Julia Jesse, Michaela Schwarz, Nina Rosa Neuendorff, Ann-Christin von Brünneck, Ioannis Anagnostopoulos, Seval Türkmen, Igor Wolfgang Blau, Thomas Burmeister, David Horst, Lars Bullinger, Jörg Westermann

https://doi.org/10.3324/haematol.2021.279134

Articles

Cardiovascular events in patients treated with chimeric antigen receptor T-cell therapy for aggressive B-cell lymphoma (965 Online Views)

Raphael E. Steiner, Jose Banchs, Efstratios Koutroumpakis, Melody Becnel, Cristina Gutierrez, Paolo Strati, Chelsea C. Pinnix, Lei Feng, Gabriela Rondon, Catherine Claussen, Nicolas Palaskas, Kaveh Karimzad, Sairah Ahmed, Sattva S. Neelapu, Elizabeth Shpall, Michael Wang, Francisco Vega, Jason Westin, Loretta J. Nastoupil, Anita Deswal

https://doi.org/10.3324/haematol.2021.280009

Letters to the Editor

Interferon alpha-induced SAMHD1 regulates human cultured megakaryocyte apoptosis and proplatelet formation (300 Online Views)

Seema Bhatlekar, Shancy Jacob, Emilia Tugolukova, Bhanu K. Manne, Yasuhiro Kosaka, Phillipe Loher, Ryan M. O’Connell, Vicente Planelles, Matthew T. Rondina, Isidore Rigoutsos, Paul F. Bray

https://doi.org/10.3324/haematol.2021.279864

Nov 4, 2021

Articles

AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia (594 Online Views)

Sean M. Post, Huaxian Ma, Prerna Malaney, Xiaorui Zhang, Marisa J.L. Aitken, Po Yee Mak, Vivian R. Ruvolo, Tomoko Yasuhiro, Ryohei Kozaki, Lauren E. Chan, Lauren B. Ostermann, Marina Konopleva, Bing Z. Carter, Courtney DiNardo, Michael D. Andreeff, Joseph D. Khoury, Peter P. Ruvolo

https://doi.org/10.3324/haematol.2021.278369

Letters to the Editor

Incidence and outcome of SARS-CoV-2 infection in patients with monoclonal gammopathy of undetermined significance: a case-control study (256 Online Views)

Nicola Sgherza, Paola Curci, Rita Rizzi, Vanda Strafella, Daniela Di Gennaro, Angelantonio Vitucci, Antonio Palma, Antonella Vita Russo Rossi, Francesco Albano, Pasquale Stefanizzi, Silvio Tafuri, Pellegrino Musto

https://doi.org/10.3324/haematol.2021.279895

Oct 28, 2021

Editorials
Article

Correction of RNA splicing defect in β654-thalassemia mice using CRISPR/Cas9 gene-editing technology (270 Online Views)

Dan Lu, Xiuli Gong, Yudan Fang, Xinbing Guo, Yanwen Chen, Fan Yang, Guijun Zhao, Qingwen Ma, Yitao Zeng, Fanyi Zeng

https://doi.org/10.3324/haematol.2020.278238

Articles

Ionophore-mediated swelling of erythrocytes as a therapeutic mechanism in sickle cell disease (203 Online Views)

Athena C. Geisness, Melissa Azul, Dillon Williams, Hannah Szafraniec, Daniel C. De Souza, John M. Higgins, David K. Wood

https://doi.org/10.3324/haematol.2021.278666

Genetic modifiers of fetal hemoglobin affect the course of sickle cell disease in patients treated with hydroxyurea (250 Online Views)

Pierre Allard, Nareen Alhaj, Stephan Lobitz, Holger Cario, Andreas Jarisch, Regine Grosse, Lena Oevermann, Dani Hakimeh, Laura Tagliaferri, Elisabeth Kohne, Annette Kopp-Schneider, Andreas E. Kulozik, Joachim B. Kunz

https://doi.org/10.3324/haematol.2021.278952

Letters to the Editor

The insecticides permethrin and chlorpyriphos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells (202 Online Views)

Virginia C Rodriguez-Cortez, Maria Pilar Navarrete-Meneses, Oscar Molina, Talia Velasco-Hernandez, Jessica Gonzalez, Paola Romecin, Francisco Gutierrez-Aguera, Heleia Roca-Ho, Meritxell Vinyoles, Eric Kowarz, Pedro Marin, Sandra Rodriguez-Perales, Carlos Gomez-Marin, Patricia Perez-Vera, Felipe Cortes-Ledesma, Anna Bigas, Andrea Terron, Clara Bueno, Pablo Menendez

https://doi.org/10.3324/haematol.2021.279047

Somatic STAT3 mutations in CD8+ T cells of healthy blood donors carrying human T-cell leukemia virus type 2 (266 Online Views)

Daehong Kim, Mikko Myllymäki, Matti Kankainen, Timo Jarvinen, Giljun Park, Roberta Bruhn, Edward L. Murphy, Satu Mustjoki

https://doi.org/10.3324/haematol.2021.279140

Oct 21, 2021

Articles

Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment (410 Online Views)

Debora Soncini, Claudia Martinuzzi, Pamela Becherini, Elisa Gelli, Samantha Ruberti, Katia Todoerti, Luca Mastracci, Paola Contini, Antonia Cagnetta, Antonella Laudisi, Fabio Guolo, Paola Minetto, Maurizio Miglino, Sara Aquino, Riccardo Varaldo, Daniele Reverberi, Matteo Formica, Mario Passalacqua, Alessio Nencioni, Antonino Neri, Mehmet K. Samur, Nikhil C. Munshi, Mariateresa Fulciniti, Roberto M. Lemoli, Michele Cea

https://doi.org/10.3324/haematol.2021.279276

Letters to the Editor

SARS-CoV-2 infection in aplastic anemia (636 Online Views)

Daniele Avenoso, Judith C.W. Marsh, Victoria Potter, Antonio Pagliuca, Simon Slade, Fiona Dignan, Eleni Tholouli, Sajjan Mittal, Bernard Davis, Sudhir Tauro, Rachel Kesse-Adu, Morag Griffin, Elspeth Payne, Shreyans Gandhi, Austin G. Kulasekararaj

https://doi.org/10.3324/haematol.2021.279928

Oct 14, 2021

Editorials
Letter to the Editor

Direct and indirect anti-leukemic properties of Activity-on-Target interferons for the treatment of T-cell acute lymphoblastic leukemia (372 Online Views)

Steven Goossens, Anje Cauwels, Tim Pieters, Renate De Smedt, Sara T’Sas, André Almeida, Willem Daneels, Pieter Van Vlierberghe, Jan Tavernier

https://doi.org/10.3324/haematol.2021.278913

Editorials
Article

Articles

Profound systemic alteration of the immune phenotype and an immunoglobulin switch in Erdheim–Chester disease in a single-center of 78 patients (427 Online Views)

Fleur Cohen Aubart, Lucie Poupel, Flora Saint-Charles, Frederic Charlotte, Youssef Arsafi, Eric Frisdal, Damien Roos-Weil, Jean-Francois Emile, Zahir Amoura, Maryse Guerin, Philippe Lesnik, Julien Haroche, Wilfried Le Goff

https://doi.org/10.3324/haematol.2021.279118

Isatuximab plus carfilzomib and dexamethasone versus carfilzomib and dexamethasone in relapsed multiple myeloma patients with renal impairment: IKEMA subgroup analysis (970 Online Views)

Marcelo Capra, Thomas Martin, Philippe Moreau, Ross Baker, Ludek Pour, Chang-Ki Min, Xavier Leleu, Mohamad Mohty, Marta Reinoso Segura, Mehmet Turgut, Richard LeBlanc, Marie-Laure Risse, Laure Malinge, Sandrine Schwab, Meletios Dimopoulos

https://doi.org/10.3324/haematol.2021.279229

Oct 7, 2021

Review Articles

Articles

Critical role of peroxisome proliferator-activated receptor α in promoting platelet hyperreactivity and thrombosis under hyperlipidemia (523 Online Views)

Li Li, Jiawei Zhou, Shuai Wang, Lei Jiang, Xiaoyan Chen, Yangfan Zhou, Jingke Li, Jingqi Shi, Pu Liu, Zheyue Shu, Frank J. Gonzalez, Aiming Liu, Hu Hu

https://doi.org/10.3324/haematol.2021.279770

Sep 30, 2021

Editorials
Article

Utility of plasma cell-free DNA for de novo detection and quantification of clonal hematopoiesis (657 Online Views)

Fernanda Gutierrez-Rodrigues, Isabel Beerman, Emma M. Groarke, Bhavisha A. Patel, Nina Spitofsky, Laura W. Dillon, Diego Quinones Raffo, Christopher S. Hourigan, Sachiko Kajigaya, Luigi Ferrucci, Neal S. Young

https://doi.org/10.3324/haematol.2021.279230

Articles

Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients (1134 Online Views)

Jennifer R. Brown, John C. Byrd, Paolo Ghia, Jeff P. Sharman, Peter Hillmen, Deborah M. Stephens, Clare Sun, Wojciech Jurczak, John M. Pagel, Alessandra Ferrajoli, Priti Patel, Lin Tao, Nataliya Kuptsova-Clarkson, Javid Moslehi, Richard R. Furman

https://doi.org/10.3324/haematol.2021.278901

Sep 23, 2021

Editorials
Article

Randomized controlled trial of geriatric consultation versus standard care in older adults with hematologic malignancies (836 Online Views)

Clark DuMontier, Hajime Uno, Tammy Hshieh, Guohai Zhou, Richard Chen, Emily S. Magnavita, Lee Mozessohn, Houman Javedan, Richard M. Stone, Robert J. Soiffer, Jane A. Driver, Gregory A. Abel

https://doi.org/10.3324/haematol.2021.278802

Articles

Retrospective analysis of pacritinib in patients with myelofibrosis and severe thrombocytopenia (741 Online Views)

Srdan Verstovsek, Ruben Mesa, Moshe Talpaz, Jean-Jacques Kiladjian, Claire N. Harrison, Stephen T. Oh, Alessandro M. Vannucchi, Raajit Rampal, Bart L. Scott, Sarah A. Buckley, Adam R. Craig, Karisse Roman-Torres, John O. Mascarenhas

https://doi.org/10.3324/haematol.2021.279415

Sep 16, 2021

Articles

Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains in vitro and in vivo (556 Online Views)

Leo Nicolai, Rainer Kaiser, Raphael Escaig, Marie-Louise Hoffknecht, Afra Anjum, Alexander Leunig, Joachim Pircher, Andreas Ehrlich, Michael Lorenz, Hellen Ishikawa-Ankerhold, William C. Aird, Steffen Massberg, Florian Gaertner

https://doi.org/10.3324/haematol.2021.278896

Sep 9, 2021

Articles

Hepcidin regulation in Kenyan children with severe malaria and non-typhoidal Salmonella bacteremia (753 Online Views)

Kelvin M. Abuga, John Muthii Muriuki, Sophie M. Uyoga, Kennedy Mwai, Johnstone Makale, Reagan M. Mogire, Alex W. Macharia, Shebe Mohammed, Esther Muthumbi, Salim Mwarumba, Neema Mturi, Philip Bejon, J. Anthony G. Scott, Manfred Nairz, Thomas N. Williams, Sarah H. Atkinson

https://doi.org/10.3324/haematol.2021.279316

Aug 26, 2021

Editorials
Article

Refined HLA-DPB1 mismatch with molecular algorithms predicts outcomes in hematopoietic stem cell transplantation (450 Online Views)

Jun Zou, Piyanuch Kongtim, Betül Oran, Vasilis Kosmoliaptsis, Yudith Carmazzi, Junsheng Ma, Liang Li, Gabriela Rondon, Samer Srour, Hannah C. Copley, David Partlow, Stefan O. Ciurea, Uri Greenbaum, Qing Ma, Elizabeth J. Shpall, Richard E. Champlin, Kai Cao

https://doi.org/10.3324/haematol.2021.278993

Editorials
Letter to the Editor

Immune thrombocytopenia following vaccination during the COVID-19 pandemic (652 Online Views)

Philip Young-Ill Choi, Danny Hsu, Huyen Anh Tran, Chee Wee Tan, Anoop Enjeti, Vivien Mun Yee Chen, Beng Hock Chong, Jennifer Curnow, Dominic Pepperell, Robert Bird

https://doi.org/10.3324/haematol.2021.279442

Aug 19, 2021

Articles

Establishment of a Bernard-Soulier syndrome model in zebrafish (536 Online Views)

Qing Lin, Riyang Zhou, Panpan Meng, Liangliang Wu, Lian Yang, Wenyu Liu, Jiaye Wu, Yuhuan Cheng, Linjuan Shi, Yiyue Zhang

https://doi.org/10.3324/haematol.2021.278893

Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study (351 Online Views)

Lale Kostakoglu, Federico Mattiello, Maurizio Martelli, Laurie H. Sehn, David Belada, Chiara Ghiggi, Neil Chua, Eva González-Barca, Xiaonan Hong, Antonio Pinto, Yuankai Shi, Yoichi Tatsumi, Christopher Bolen, Andrea Knapp, Gila Sellam, Tina Nielsen, Deniz Sahin, Umberto Vitolo, Marek Trněný

https://doi.org/10.3324/haematol.2021.278663

Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease (622 Online Views)

Eileen Haring, Geoffroy Andrieux, Franziska M. Uhl, Máté Krausz, Michele Proietti, Barbara Sauer, Philipp R. Esser, Stefan F. Martin, Dietmar Pfeifer, Annette Schmitt-Graeff, Justus Duyster, Natalie Köhler, Bodo Grimbacher, Melanie Boerries, Konrad Aumann, Robert Zeiser, Petya Apostolova

https://doi.org/10.3324/haematol.2021.278387

Errata Corrige

Long-term outcomes from the phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma (1239 Online Views)

Johannes Duell, Kami J. Maddocks, Eva González-Barca, Wojciech Jurczak, Anna Marina Liberati, Sven de Vos, Zsolt Nagy, Aleš Obr, Gianluca Gaidano, Pau Abrisqueta, Nagesh Kalakonda, Marc André, Martin Dreyling, Tobias Menne, Olivier Tournilhac, Marinela Augustin, Andreas Rosenwald, Maren Dirnberger-Hertweck, Johannes Weirather, Sumeet Ambarkhane, Gilles Salles

https://doi.org/10.3324/haematol.2021.279802

Aug 12, 2021

Editorials
Case Report

Immune-mediated thrombotic thrombocytopenic purpura following Pfizer-BioNTech COVID-19 vaccine (252 Online Views)

Gaetano Giuffrida, Annalisa Condorelli, Mary Ann Di Giorgio, Uros Markovic, Roberta Sciortino, Daniela Nicolosi, Francesco Di Raimondo

https://doi.org/10.3324/haematol.2021.279535

Articles

One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors (578 Online Views)

Dietger Niederwieser, Helen Baldomero, Nosa Bazuaye, Caitrin Bupp, Naeem Chaudhri, Selim Corbacioglu, Alaa Elhaddad, Cristóbal Frutos, Sebastian Galeano, Nada Hamad, Amir Ali Hamidieh, Shahrukh Hashmi, Aloysius Ho, Mary M. Horowitz, Minako Iida, Gregorio Jaimovich, Amado Karduss, Yoshihisa Kodera, Nicolaus Kröger, Regis Péffault de Latour, Jong Wook Lee, Juliana Martínez-Rolón, Marcelo C. Pasquini, Jakob Passweg, Kristjan Paulson, Adriana Seber, John A. Snowden, Alok Srivastava, Jeff Szer, Daniel Weisdorf, Nina Worel, Mickey B.C. Koh, Mahmoud Aljurf, Hildegard Greinix, Yoshiko Atsuta, Wael Saber

https://doi.org/10.3324/haematol.2021.279189

Whole-genome profiling of primary cutaneous anaplastic large cell lymphoma (660 Online Views)

Armando N. Bastidas Torres, Rutger C. Melchers, Liana van Grieken, Jacoba J. Out-Luiting, Hailiang Mei, Cedrick Agaser, Thomas B. Kuipers, Koen D. Quint, Rein Willemze, Maarten H. Vermeer, Cornelis P. Tensen

https://doi.org/10.3324/haematol.2020.263251

Renal function and clinical outcome of patients with cancer-associated venous thromboembolism randomized to receive apixaban or dalteparin. Results from the Caravaggio trial (649 Online Views)

Cecilia Becattini, Rupert Bauersachs, Giorgio Maraziti, Laurent Bertoletti, Alexander Cohen, Jean M. Connors, Dario Manfellotto, Antonio Sanchez, Benjamin Brenner, Giancarlo Agnelli

https://doi.org/10.3324/haematol.2021.279072

Aug 5, 2021

Editorials
Article

Characteristics and outcome of patients with core binding factor acute myeloid leukemia and FLT3-ITD: results from an international collaborative study (511 Online Views)

Sabine Kayser, Michael Kramer, David Martínez-Cuadrón, Justin Grenet, Klaus H. Metzeler, Zuzana Sustkova, Marlise R. Luskin, Andrew M. Brunner, Michelle A. Elliott, Cristina Gil, Sandra Casal Marini, Zdeněk Ráčil, Petr Cetkovsky, Jan Novak, Alexander E. Perl, Uwe Platzbecker, Friedrich Stölzel, Anthony D. Ho, Christian Thiede, Richard M. Stone, Christoph Röllig, Pau Montesinos, Richard F. Schlenk, Mark J. Levis

https://doi.org/10.3324/haematol.2021.278645

Editorials
Letter to the Editor

Dual pyroptotic biomarkers predict erythroid response in lower risk non-del(5q) myelodysplastic syndromes treated with lenalidomide and recombinant erythropoietin (429 Online Views)

Chen Wang, Kathy L. McGraw, Amy F. McLemore, Rami Komrokji, Ashley A. Basiorka, Najla Al Ali, Jeffrey E. Lancet, Eric Padron, Olivier Kosmider, Michaela Fontenay, Pierre Fenaux, Alan F. List, David A. Sallman

https://doi.org/10.3324/haematol.2021.278855

Articles

Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets (619 Online Views)

Inga Scheller, Sarah Beck, Vanessa Göb, Carina Gross, Raluca A. I. Neagoe, Katja Aurbach, Markus Bender, David Stegner, Zoltan Nagy, Bernhard Nieswandt

https://doi.org/10.3324/haematol.2021.278537

Clofarabine increases the eradication of minimal residual disease of primary Bprecursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome (358 Online Views)

Gabriele Escherich, Udo zur Stadt, Arndt Borkhardt, Dagmar Dilloo, Jörg Faber, Tobias Feuchtinger, Thomas Imschweiler, Norbert Jorch, Arnulf Pekrun, Irene Schmid, Franziska Schramm, Michael Spohn, Martin Zimmermann, Martin A Horstmann

https://doi.org/10.3324/haematol.2021.279357

Jul 29, 2021

Editorials

Editorials
Article

Humoral serologic response to the BNT162b2 vaccine is abrogated in lymphoma patients within the first 12 months following treatment with anti-CD2O antibodies (827 Online Views)

Ronit Gurion, Uri Rozovski, Gilad Itchaki, Anat Gafter-Gvili, Chiya Leibovitch, Pia Raanani, Haim Ben-Zvi, Moran Szwarcwort, Mor Taylor-Abigadol, Eldad J. Dann, Nurit Horesh, Tsofia Inbar, Inna Tzoran, Noa Lavi, Riva Fineman, Shimrit Ringelstein-Harlev, Netanel A. Horowitz

https://doi.org/10.3324/haematol.2021.279216
Article

Safety and efficacy of BNT162b mRNA Covid19 Vaccine in patients with chronic lymphocytic leukemia (2065 Online Views)

Ohad Benjamini, Lior Rokach, Gilad Itchaki, Andrei Braester, Lev Shvidel, Neta Goldschmidt, Shirley Shapira, Najib Dally, Abraham Avigdor, Galia Rahav, Yaniv Lustig, Shirley Shapiro Ben David, Riva Fineman, Alona Paz, Osnat Bairey, Aaron Polliack, Ilana Levy, Tamar Tadmor

https://doi.org/10.3324/haematol.2021.279196

Articles

UBA6 and NDFIP1 regulate the degradation of ferroportin (596 Online Views)

Lisa Traeger, Steffen B. Wiegand, Andrew J. Sauer, Benjamin H.P. Corman, Kathryn M. Peneyra, Florian Wunderer, Anna Fischbach, Aranya Bagchi, Rajeev Malhotra, Warren M. Zapol, Donald B. Bloch

https://doi.org/10.3324/haematol.2021.278530

Phase I/II clinical trial of temsirolimus and lenalidomide in patients with relapsed and refractory lymphomas (825 Online Views)

Ajay Major, Justin Kline, Theodore G. Karrison, Paul A. S. Fishkin, Amy S. Kimball, Adam M. Petrich, Sreenivasa Nattam, Krishna Rao, Bethany G. Sleckman, Kenneth Cohen, Koen van Besien, Aaron P. Rapoport, Sonali M. Smith

https://doi.org/10.3324/haematol.2021.278853

Jul 22, 2021

Articles

Dose-Adjusted Epoch and Rituximab for the treatment of double expressor and double hit diffuse large B-cell lymphoma: impact of TP53 mutations on clinical outcome (900 Online Views)

Anna Dodero, Anna Guidetti, Fabrizio Marino, Alessandra Tucci, Francesco Barretta, Alessandro Re, Monica Balzarotti, Cristiana Carniti, Chiara Monfrini, Annalisa Chiappella, Antonello Cabras, Fabio Facchetti, Martina Pennisi, Daoud Rahal, Valentina Monti, Liliana Devizzi, Rosalba Miceli, Federica Cocito, Lucia Farina, Francesca Ricci, Giuseppe Rossi, Carmelo Carlo-Stella, Paolo Corradini

https://doi.org/10.3324/haematol.2021.278638

Prephase rituximab/prednisone therapy and aging-related, pro-inflammatory cytokine milieu in older, vulnerable patients with newly diagnosed diffuse large B-cell lymphoma (615 Online Views)

Richard J. Lin, Colette N. Owens, Esther Drill, Augustine Iannotta, Mayan Oliveros, Dylan L. Schick, Ariela Noy, John F. Gerecitano, Pamela R. Drullinsky, Philip C. Caron, Anita Kumar, Matthew J. Matasar, Craig Moskowitz, Beatriz Korc-Grodzicki, Andrew D. Zelenetz, Gilles A. Salles, Paul A. Hamlin

https://doi.org/10.3324/haematol.2021.278719

Complement dysregulation is associated with severe COVID-19 illness (977 Online Views)

Jia Yu, Gloria F. Gerber, Hang Chen, Xuan Yuan, Shruti Chaturvedi, Evan M. Braunstein, Robert A. Brodsky

https://doi.org/10.3324/haematol.2021.279155

Jul 15, 2021

Articles

Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia (477 Online Views)

Dimitrios Papaioannou, Hatice G. Ozer, Deedra Nicolet, Amog P. Urs, Tobias Herold, Krzysztof Mrózek, Aarif M.N. Batcha, Klaus H. Metzeler, Ayse S. Yilmaz, Stefano Volinia, Marius Bill, Jessica Kohlschmidt, Maciej Pietrzak, Christopher J. Walker, Andrew J. Carroll, Jan Braess, Bayard L. Powell, Ann-Kathrin Eisfeld, Geoffrey L. Uy, Eunice S. Wang, Jonathan E. Kolitz, Richard M. Stone, Wolfgang Hiddemann, John C. Byrd, Clara D. Bloomfield, Ramiro Garzon

https://doi.org/10.3324/haematol.2021.266643

Jul 8, 2021

Articles

Toxicity and efficacy of chimeric antigen receptor T-cell in patients with diffuse large B cell lymphoma above the age of 70 years compare to younger patients – a matched control multi-center cohort study (1199 Online Views)

Ron Ram, Sigal Grisariu, Liat Shargian-Alon, Odelia Amit, Yaeli Bar-On, Polina Stepensky, Moshe Yeshurun, Batia Avni, David Hagin, Chava Perry, Ronit Gurion, Nadav Sarid, Yair Herishanu, Ronit Gold, Chen Glait-Santar, Sigi Kay, Irit Avivi

https://doi.org/10.3324/haematol.2021.278288

Germline GATA2 variant disrupting endothelial eNOS cell function and angiogenesis can be restored by c-Jun/AP-1 upregulation (587 Online Views)

Giulio Purgatorio, Elisa Piselli, Giuseppe Guglielmini, Emanuela Falcinelli, Loredana Bury, Valeria Di Battista, Fabrizia Pellanera, Francesca Milano, Caterina Matteucci, Cristina Mecucci, Paolo Gresele

https://doi.org/10.3324/haematol.2021.278450

Jul 1, 2021

Editorials
Article

Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy (656 Online Views)

Seth E. Karol, Deqing Pei, Colton A. Smith, Yiwei Liu, Wenjian Yang, Nancy M. Kornegay, John C. Panetta, Kristine R. Crews, Cheng Cheng, Emily R. Finch, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Tanja A. Gruber, Jun J. Yang, William E. Evans, Sima Jeha, Ching-Hon Pui, Mary V. Relling

https://doi.org/10.3324/haematol.2021.278411

Articles

A homozygous duplication of the FGG exon 8-intron 8 junction causes congenital afibrinogenemia. Lessons learned from the study of a large consanguineous Turkish family (498 Online Views)

Michel Guipponi, Frédéric Masclaux, Frédérique Sloan-Béna, Corinne Di Sanza, Namik Özbek, Flora Peyvandi, Marzia Menegatti, Alessandro Casini, Baris Malbora, Marguerite Neerman-Arbez

https://doi.org/10.3324/haematol.2021.278945

Jun 24, 2021

Articles

Improved outcome of patients with graft-versus-host disease after allogeneic hematopoietic cell transplantation for hematologic malignancies over time: an EBMT mega-file study (550 Online Views)

Hildegard T. Greinix, Dirk-Jan Eikema, Linda Koster, Olaf Penack, Ibrahim Yakoub-Agha, Silvia Montoto, Christian Chabannon, Jan Styczynski, Arnon Nagler, Marie Robin, Stephen Robinson, Yves Chalandon, Malgorzata Mikulska, Stefan Schönland, Zinaida Peric, Annalisa Ruggeri, Francesco Lanza, Liesbeth C. de Wreede, Mohamad Mohty, Grzegorz W. Basak, Nicolaus Kröger

https://doi.org/10.3324/haematol.2020.265769

Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B cell lymphoma (694 Online Views)

Sara Napoli, Luciano Cascione, Andrea Rinaldi, Filippo Spriano, Francesca Guidetti, Fangwen Zhang, Maria Teresa Cacciapuoti, Afua Adjeiwaa Mensah, Giulio Sartori, Nicolas Munz, Mattia Forcato, Silvio Bicciato, Annalisa Chiappella, Paola Ghione, Olivier Elemento, Leandro Cerchietti, Giorgio Inghirami, Francesco Bertoni

https://doi.org/10.3324/haematol.2020.267096

Older patients (aged ≥60 years) with previously untreated advanced-stage classical Hodgkin lymphoma: a detailed analysis from the phase III ECHELON-1 study (1018 Online Views)

Andrew M. Evens, Joseph M. Connors, Anas Younes, Stephen M. Ansell, Won Seog Kim, John Radford, Tatyana Feldman, Joseph Tuscano, Kerry J. Savage, Yasuhiro Oki, Andrew Grigg, Christopher Pocock, Monika Dlugosz-Danecka, Keenan Fenton, Andres Forero-Torres, Rachael Liu, Hina Jolin, Ashish Gautam, Andrea Gallamini

https://doi.org/10.3324/haematol.2021.278438

Response and resistance to CDK12 inhibition in aggressive B-cell lymphomas (762 Online Views)

Jing Gao, Michelle Y. Wang, Yuan Ren, Tint Lwin, Tao Li, Joy C Yan, Eduardo M. Sotomayor, Derek R Duckett, Bijal D. Shah, Kenneth H. Shain, Xiaohong Zhao, Jianguo Tao

https://doi.org/10.3324/haematol.2021.278743

Natural history of Waldenström macroglobulinemia following acquired resistance to ibrutinib monotherapy (565 Online Views)

Joshua N. Gustine, Shayna Sarosiek, Catherine A. Flynn, Kirsten Meid, Carly Leventoff, Timothy White, Maria Luisa Guerrera, Lian Xu, Amanda Kofides, Nicholas Tsakmaklis, Manit Munshi, Maria Demos, Christopher J. Patterson, Xia Liu, Guang Yang, Zachary R. Hunter, Andrew R. Branagan, Steven P. Treon, Jorge J. Castillo

https://doi.org/10.3324/haematol.2021.279112

Jun 17, 2021

Editorials
Article

Efficacy and safety assessment of prolonged maintenance with subcutaneous rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: results of the Phase III MabCute study (548 Online Views)

Simon Rule, Wolney Gois Barreto, Javier Briones, Angelo M. Carella, Olivier Casasnovas, Chris Pocock, Clemens-Martin Wendtner, Francesco Zaja, Susan Robson, Lachlan MacGregor, Roger R. Tschopp, Sonja Nick, Martin Dreyling

https://doi.org/10.3324/haematol.2020.274803

Editorials
Article

RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells (451 Online Views)

Orsola di Martino, Margaret A. Ferris, Gayla Hadwiger, Soyi Sarkar, Anh Vu, María P. Menéndez-Gutiérrez, Mercedes Ricote, John S. Welch

https://doi.org/10.3324/haematol.2021.278603

Articles

The GPIbα intracellular tail – role in transducing VWF- and collagen/GPVI-mediated signaling (458 Online Views)

Adela Constantinescu-Bercu, Yuxiao A. Wang, Kevin J. Woollard, Pierre Mangin, Karen Vanhoorelbeke, James T.B. Crawley, Isabelle I. Salles-Crawley

https://doi.org/10.3324/haematol.2020.278242

Jun 10, 2021

Articles

Inhibitors of A Disintegrin and Metalloproteinases-10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect (658 Online Views)

Roberta Pece, Sara Tavella, Delfina Costa, Serena Varesano, Caterina Camodeca, Doretta Cuffaro, Elisa Nuti, Armando Rossello, Massimo Alfano, Cristina D’Arrigo, Denise Galante, Jean-Louis Ravetti, Marco Gobbi, Francesca Tosetti, Alessandro Poggi, Maria Raffaella Zocchi

https://doi.org/10.3324/haematol.2021.278469

Jun 3, 2021

Articles

The complex karyotype landscape in chronic lymphocytic leukemia allows to refine the risk of Richter syndrome transformation (665 Online Views)

Andrea Visentin, Laura Bonaldi, Gian Matteo Rigolin, Francesca Romana Mauro, Annalisa Martines, Federica Frezzato, Stefano Pravato, Leila Romano Gargarella, Maria Antonella Bardi, Maurizio Cavallari, Eleonora Volta, Francesco Cavazzini, Mauro Nanni, Monica Facco, Francesco Piazza, Anna Guarini, Robin Foà, Gianpietro Semenzato, Antonio Cuneo, Livio Trentin

https://doi.org/10.3324/haematol.2021.278304

IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load (521 Online Views)

Dianna Hussmann, Anna Starnawska, Louise Kristensen, Iben Daugaard, Astrid Thomsen, Tina E. Kjeldsen, Christine Søholm Hansen, Jonas Bybjerg-Grauholm, Karina Dalsgaard Johansen, Maja Ludvigsen, Thomas Kristensen, Thomas Stauffer Larsen, Michael Boe Møller, Charlotte Guldborg Nyvold, Lise Lotte Hansen, Tomasz K. Wojdacz

https://doi.org/10.3324/haematol.2021.278477

Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome (869 Online Views)

Ayala Tovy, Carina Rosas, Amos S. Gaikwad, Geraldo Medrano, Linda Zhang, Jaime M. Reyes, Yung-Hsin Huang, Tastuhiko Arakawa, Kristen Kurtz, Shannon E. Conneely, Anna G. Guzman, Rogelio Aguilar, Anne Gao, Chun-Wei Chen, Jean J. Kim, Melissa T. Carter, Amaia Lasa-Aranzasti, Irene Valenzuela, Lionel Van Maldergem, Lorenzo Brunetti, M. John Hicks, Andrea N. Marcogliese, Margaret A. Goodell, Rachel E. Rau

https://doi.org/10.3324/haematol.2021.278990

May 6, 2021

Articles

IL4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation (887 Online Views)

Pablo Peña-Martínez, Ramprasad Ramakrishnan, Carl Högberg, Caroline Jansson, David Gisselsson Nord, Marcus Järås

https://doi.org/10.3324/haematol.2020.270421

Improved outcomes of high-risk relapsed Hodgkin lymphoma patients after high-dose chemotherapy: a 15-year analysis (944 Online Views)

Yago Nieto, Stephen Gruschkus, Benigno C Valdez, Roy B Jones, Paolo Anderlini, Chitra Hosing, Uday Popat, Muzaffar Qazilbash, Partow Kebriaei, Amin Alousi, Neeraj Saini, Samer Srour, Katayoun Rezvani, Jeremy Ramdial, Melissa Barnett, Alison Gulbis, Terri Lynn Shigle, Sairah Ahmed, Swaminathan Iyer, Hun Lee, Ranjit Nair, Simrit Parmar, Raphael Steiner, Bouthaina Dabaja, Chelsea Pinnix, Jillian Gunther, Branko Cuglievan, Kris Mahadeo, Sajad Khazal, Hubert Chuang, Richard Champlin, Elizabeth J Shpall, Borje S Andersson

https://doi.org/10.3324/haematol.2021.278311

DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome (778 Online Views)

Katia Todoerti, Domenica Ronchetti, Vanessa Favasuli, Francesco Maura, Fortunato Morabito, Niccolò Bolli, Elisa Taiana, Antonino Neri

https://doi.org/10.3324/haematol.2021.278342

Apr 29, 2021

Articles

LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for Mixed Lineage Leukemia-Rearranged acute leukemia (1013 Online Views)

Gabriel Gracia-Maldonado, Jason Clark, Matthew Burwinkel, Brenay Greenslade, Mark Wunderlich, Nathan Salomonis, Dario Leone, Evelina Gatti, Philippe Pierre, Ashish R. Kumar, Lynn H. Lee

https://doi.org/10.3324/haematol.2020.257451

Apr 22, 2021

Articles

Brain injury pathophysiology study by a multimodal approach in children with sickle cell anemia with no intra or extra cranial arteriopathy (499 Online Views)

Valentine Brousse, Corinne Pondarre, Manoelle Kossorotoff, Cecile Arnaud, Annie Kamdem, Mariane de Montalembert, Benedicte Boutonnat-Faucher, Slimane Allali, Hélène Bourdeau, Keyne Charlot, Sebastien Bertil, Lydie da Costa, Philippe Connes, David Grévent, Suzanne Verlhac

https://doi.org/10.3324/haematol.2020.278226

Apr 15, 2021

Articles

Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia (1364 Online Views)

Dan Cojocari, Brianna N Smith, Julie J. Purkal, Maria P. Arrate, Jason D. Huska, Yu Xiao, Agnieszka Gorska, Leah J. Hogdal, Haley E. Ramsey, Erwin R Boghaert, Darren C. Phillips, Michael R. Savona

https://doi.org/10.3324/haematol.2020.272609

Apr 8, 2021

Articles

Apr 1, 2021

Articles

Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (1315 Online Views)

Armando N. Bastidas Torres, Davy Cats, Jacoba J. Out-Luiting, Daniele Fanoni, Hailiang Mei, Luigia Venegoni, Rein Willemze, Maarten H. Vermeer, Emilio Berti, Cornelis P. Tensen

https://doi.org/10.3324/haematol.2020.274506

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma (1620 Online Views)

Man Chun John Ma, Saber Tadros, Alyssa Bouska, Tayla Heavican, Haopeng Yang, Qing Deng, Dalia Moore, Ariz Akhter, Keenan Hartert, Neeraj Jain, Jordan Showell, Sreejoyee Ghosh, Lesley Street, Marta Davidson, Christopher Carey, Joshua Tobin, Deepak Perumal, Julie M. Vose, Matthew A. Lunning, Aliyah R. Sohani, Benjamin J. Chen, Shannon Buckley, Loretta J. Nastoupil, R. Eric Davis, Jason R. Westin, Nathan H. Fowler, Samir Parekh, Maher Gandhi, Sattva Neelapu, Douglas Stewart, Kapil Bhalla, Javeed Iqbal, Timothy Greiner, Scott J. Rodig, Adnan Mansoor, Michael R. Green

https://doi.org/10.3324/haematol.2020.274258

Mar 25, 2021

Articles

Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin mediated clearance (773 Online Views)

Soracha E. Ward, Jamie M. O’Sullivan, Alan B. Moran, Daniel I. R. Spencer, Richard A. Gardner, Jyotika Sharma, Judicael Fazavana, Marco Monopoli, Thomas A.J. McKinnon, Alain Chion, Sandra Haberichter, James S. O’Donnell

https://doi.org/10.3324/haematol.2020.274720

Mar 18, 2021

Articles

Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia (1311 Online Views)

Taeko Kaburagi, Genki Yamato, Norio Shiba, Kenichi Yoshida, Yusuke Hara, Ken Tabuchi, Yuichi Shiraishi, Kentaro Ohki, Manabu Sotomatsu, Hirokazu Arakawa, Hidemasa Matsuo, Akira Shimada, Tomohiko Taki, Nobutaka Kiyokawa, Daisuke Tomizawa, Keizo Horibe, Satoru Miyano, Takashi Taga, Souichi Adachi, Seishi Ogawa, Yasuhide Hayashi

https://doi.org/10.3324/haematol.2020.269431

Integrative prognostic models predict long-term survival after immunochemotherapy in chronic lymphocytic leukemia patients (685 Online Views)

Johannes Bloehdorn, Julia Krzykalla, Karlheinz Holzmann, Andreas Gerhardinger, Billy Michael Chelliah Jebaraj, Jasmin Bahlo, Kathryn Humphrey, Eugen Tausch, Sandra Robrecht, Daniel Mertens, Christof Schneider, Kirsten Fischer, Michael Hallek, Hartmut Döhner, Axel Benner, Stephan Stilgenbauer

https://doi.org/10.3324/haematol.2020.251561

Mar 11, 2021

Articles

Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients (841 Online Views)

Silvia Ramos-Campoy, Anna Puiggros, Sílvia Beà, Sandrine Bougeon, María José Larráyoz, Dolors Costa, Helen Parker, Gian Matteo Rigolin, Margarita Ortega, María Laura Blanco, Rosa Collado, Rocío Salgado, Tycho Baumann, Eva Gimeno, Carolina Moreno, Francesc Bosch, Xavier Calvo, María José Calasanz, Antonio Cuneo, Jonathan C. Strefford, Florence Nguyen-Khac, David Oscier, Claudia Haferlach, Jacqueline Schoumans, Blanca Espinet

https://doi.org/10.3324/haematol.2020.274456

Clonal evolution in chronic lymphocytic leukemia is scant in relapsed but accelerated in refractory cases after chemo(immune)therapy (829 Online Views)

Marc Zapatka, Eugen Tausch, Selcen Öztürk, Deyan Yordanov Yosifov, Martina Seiffert, Thorsten Zenz, Christof Schneider, Johannes Blöhdorn, Hartmut Döhner, Daniel Mertens, Peter Lichter, Stephan Stilgenbauer

https://doi.org/10.3324/haematol.2020.265777

ZRSR1 cooperates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells (790 Online Views)

Vikas Madan, Zeya Cao, Weoi Woon Teoh, Pushkar Dakle, Lin Han, Pavithra Shyamsunder, Maya Jeitany, Siqin Zhou, Jia Li, Hazimah Binte Mohd Nordin, JiZhong Shi, Shuizhou Yu, Henry Yang, Md Zakir Hossain, Wee Joo Chng, H. Phillip Koeffler

https://doi.org/10.3324/haematol.2020.260562

Feb 25, 2021

Articles

Unique ethnic features of DDX41 mutations in patients with idiopathic cytopenia of undetermined significance, myelodysplastic syndrome, or acute myeloid leukemia (1069 Online Views)

Eun-Ji Choi, Young-Uk Cho, Eun-Hye Hur, Seongsoo Jang, Nayoung Kim, Han-Seung Park, Jung-Hee Lee, Kyoo-Hyung Lee, Si-Hwan Kim, Sang-Hyun Hwang, Eul-Ju Seo, Chan-Jeoung Park, Je-Hwan Lee

https://doi.org/10.3324/haematol.2020.270553

Feb 18, 2021

Articles

Identification of a novel genetic locus associated with immune mediated thrombotic thrombocytopenic purpura (612 Online Views)

Matthew J. Stubbs, Paul Coppo, Chris Cheshire, Agnès Veyradier, Stephanie Dufek, Adam P. Levine, Mari Thomas, Vaksha Patel, John O. Connolly, Michael Hubank, Ygal Benhamou, Lionel Galicier, Pascale Poullin, Robert Kleta, Daniel P. Gale, Horia Stanescu, Marie A Scully

https://doi.org/10.3324/haematol.2020.274639

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma (1545 Online Views)

Kanagaraju Ponnusamy, Maria Myrsini Tzioni, Murshida Begum, Mark E. Robinson, Valentina S. Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, Irene Roberts, Pritesh Trivedi, Holger W. Auner, Kikkeri Naresh, Aristeidis Chaidos, Anastasios Karadimitris

https://doi.org/10.3324/haematol.2020.274480

Feb 11, 2021

Articles

Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia (1050 Online Views)

Marion K. Mateos, Glenn M. Marshall, Pasquale M. Barbaro, Michael C.J. Quinn, Carly George, Chelsea Mayoh, Rosemary Sutton, Tamas Revesz, Jodie E. Giles, Draga Barbaric, Frank Alvaro, Françoise Mechinaud, Daniel Catchpoole, John A. Lawson, Georgia Chenevix-Trench, Stuart MacGregor, Rishi S. Kotecha, Luciano Dalla-Pozza, Toby N. Trahair

https://doi.org/10.3324/haematol.2020.268565

Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes (884 Online Views)

Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Pino J. Poddighe, Giovanni A.M. Povoleri, Jessica A. Timms, Shahram Kordasti, Tanja D. de Gruijl, Arjan A. van de Loosdrecht

https://doi.org/10.3324/haematol.2020.268136

Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis (1140 Online Views)

Rachel Dobson, Peter Y. Du, Lívia Rásó-Barnett, Wen-Qing Yao, Zi Chen, Calogero Casa, Hesham EI-Daly, Lorant Farkas, Elizabeth Soilleux, Penny Wright, John W. Grant, Manuel Rodriguez-Justo, George A. Follows, Hala Rashed, Margarete Fabre, E. Joanna Baxter, George Vassiliou, Andrew Wotherspoon, Ayoma D. Attygalle, Hongxiang Liu, Ming-Qing Du

https://doi.org/10.3324/haematol.2020.265991

Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates (1329 Online Views)

Martina H. Lundberg Slingsby, Prakrith Vijey, I-Ting Tsai, Harvey Roweth, Genevieve Couldwell, Adrian R. Wilkie, Hans Gaus, Jazana M. Goolsby, Ross Okazaki, Brooke E. Terkovich, John W. Semple, Jonathan N. Thon, Scott P. Henry, Padmakumar Narayanan, Joseph E. Italiano Jr.

https://doi.org/10.3324/haematol.2020.260059

Jan 14, 2021

Articles

Long term follow-up of pediatric-onset Evans syndrome: broad immunopathological manifestations and high treatment burden (824 Online Views)

Thomas Pincez, Helder Fernandes, Thierry Leblanc, Gérard Michel, Vincent Barlogis, Yves Bertrand, Bénédicte Neven, Wadih Abou Chahla, Marlène Pasquet, Corinne Guitton, Aude Marie-Cardine, Isabelle Pellier, Corinne Armari-Alla, Joy Benadiba, Pascale Blouin, Eric Jeziorski, Frédéric Millot, Catherine Paillard, Caroline Thomas, Nathalie Cheikh, Sophie Bayart, Fanny Fouyssac, Christophe Piguet, Marianna Deparis, Claire Briandet, Eric Dore, Capucine Picard, Frédéric Rieux-Laucat, Judith Landman-Parker, Guy Leverger, Nathalie Aladjidi

https://doi.org/10.3324/haematol.2020.271106

Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity (2007 Online Views)

Amanda Amoah, Anja Keller, Ramiz Emini, Markus Hoenicka, Andreas Liebold, Angelika Vollmer, Karina Eiwen, Karin Soller, Vadim Sakk, Yi Zheng, Maria Carolina Florian, Hartmut Geiger

https://doi.org/10.3324/haematol.2020.269670

Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector (1409 Online Views)

Yang Liu, Maria Dahl, Shubhranshu Debnath, Michael Rothe, Emma M. Smith, Tan Hooi Min Grahn, Sarah Warsi, Jun Chen, Johan Flygare, Axel Schambach, Stefan Karlsson

https://doi.org/10.3324/haematol.2020.269142

Human invariant natural killer T cells promote tolerance by preferential apoptosis induction of conventional dendritic cells (665 Online Views)

Hannes Schmid, Emmanuelle M. Ribeiro, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Ruoyun Dong, Timo Munz, Klaus Schulze-Osthoff, Stephan Hailfinger, Corina Schneidawind, Dominik Schneidawind

https://doi.org/10.3324/haematol.2020.267583

Jan 7, 2021

Articles

Risk factors for endocrine complications in transfusion-dependent thalassemia patients on chelation therapy with deferasirox: a risk assessment study from a multicentre nation-wide cohort (943 Online Views)

Maddalena Casale, Gian Luca Forni, Elena Cassinerio, Daniela Pasquali, Raffaella Origa, Marilena Serra, Saveria Campisi, Angelo Peluso, Roberta Renni, Alessandro Cattoni, Elisa De Michele, Massimo Allò, Maurizio Poggi, Francesca Ferrara, Rosanna Di Concilio, Filomena Sportelli, Antonella Quarta, Maria Caterina Putti, Lucia Dora Notarangelo, Antonella Sau, Saverio Ladogana, Immacolata Tartaglione, Stefania Picariello, Alessia Marcon, Patrizia Sturiale, Domenico Roberti, Antonio Ivan Lazzarino, Silverio Perrotta

https://doi.org/10.3324/haematol.2020.272419

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia. (2833 Online Views)

Rudy Birsen, Clement Larrue, Justine Decroocq, Natacha Johnson, Nathan Guiraud, Mathilde Gotanegre, Lilia Cantero-Aguilar, Eric Grignano, Tony Huynh, Michaela Fontenay, Olivier Kosmider, Patrick Mayeux, Nicolas Chapuis, Jean Emmanuel Sarry, Jerome Tamburini, Didier Bouscary

https://doi.org/10.3324/haematol.2020.259531

Dec 30, 2020

Articles

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide. (3198 Online Views)

Mark Gurney, Arwen Stikvoort, Emma Nolan, Lucy Kirkham-McCarthy, Stanislav Khoruzhenko, Rama Shivakumar, Sonja Zweegman, Niels W.C.J. van de Donk, Tuna Mutis, Eva Szegezdi, Subhashis Sarkar, Michael O’Dwyer

https://doi.org/10.3324/haematol.2020.271908

May 10, 2018

Articles

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells (582 Online Views)

Beibei Zhang, Pilar Ayuda Durán, Laure Piechaczyk, Yngvar Fløisand, Mireia Mayoral Safont Safont, Ida Tveit Karlsen, Zina Fandalyuk, Dagim Tadele, Pepijn van Mierlo, Alexander D. Rowe, Joseph M. Robertson, Bjørn Tore Gjertsen, Emmet McCormack, Jorrit M. Enserink, Bjørn Tore Gjertsen Group, Emmet McCormack Group

https://doi.org/10.3324/haematol.2018.189399