Early view

May 12, 2022

Editorials
Letter to the Editor

Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation (64 Online Views)

Annalisa Ruggeri, Liesbeth C. de Wreede, Carlheinz R. Müller, Pietro Crivello, Edouard F. Bonneville, Effie W. Petersdorf, Gerard Socié, Valérie Dubois, Riitta Niittyvuopio, Juha Peräsaari, Ibrahim Yakoub-Agha, Jan J. Cornelissen, Lotte Wieten, Tobias Gedde-Dahl, Edouard Forcade, Charles R. Crawley, Steven G.E. Marsh, Virginie Gandemer, Eleni Tholouli, Claude-Eric Bulabois, Anne Huynh, Goda Choi, Eric Deconinck, Maija Itäla-Remes, Stig Lenhoff, Mats Bengtsson, Jan-Erik Johansson, Gwendolyn van Gorkom, Jorinde D. Hoogenboom, Luca Vago, Vanderson Rocha, Chiara Bonini, Christian Chabannon, Katharina Fleischhauer

https://doi.org/10.3324/haematol.2021.280055

Articles

Assessment of functional shunting in patients with sickle cell disease (39 Online Views)

Liza Afzali-Hashemi, Lena Václavů, John C. Wood, Bart J. Biemond, Aart J. Nederveen, Henk J.M.M. Mutsaerts, Anouk Schrantee

https://doi.org/10.3324/haematol.2021.280183

COVID-19 in adult acute myeloid leukemia patients: a long-term followup study from the European Hematology Association survey (EPICOVIDEHA) (179 Online Views)

Francesco Marchesi, Jon Salmanton-García, Ziad Emarah, Klára Piukovics, Marcio Nucci, Alberto López-García, Zdeněk Ráčil, Francesca Farina, Marina Popova, Sofia Zompi, Ernesta Audisio, Marie-Pierre Ledoux, Luisa Verga, Barbora Weinbergerová, Tomas Szotkovski, Maria Gomes Da Silva, Nicola Fracchiolla, Nick De Jonge, Graham Collins, Monia Marchetti, Gabriele Magliano, Carolina García-Vidal, Monika M. Biernat, Jaap Van Doesum, Marina Machado, Fatih Demirkan, Murtadha Al-Khabori, Pavel Žák, Benjamín Víšek, Igor Stoma, Gustavo-Adolfo Méndez, Johan Maertens, Nina Khanna, Ildefonso Espigado, Giulia Dragonetti, Luana Fianchi, Maria Ilaria Del Principe, Alba Cabirta, Irati Ormazabal-Vélez, Ozren Jaksic, Caterina Buquicchio, Valentina Bonuomo, Josip Batinić, Ali S. Omrani, Sylvain Lamure, Olimpia Finizio, Noemí Fernández, Iker Falces-Romero, Ola Blennow, Rui Bergantim, Natasha Ali, Sein Win, Jens Van Praet, Maria Chiara Tisi, Ayten Shirinova, Martin Schönlein, Juergen Prattes, Monica Piedimonte, Verena Petzer, Milan Navrátil, Austin Kulasekararaj, Pavel Jindra, Jiří Sramek, Andreas Glenthøj, Rita Fazzi, Cristina De Ramón-Sánchez, Chiara Cattaneo, Maria Calbacho, Nathan C. Bahr, Shaimaa El-Ashwah, Raul Cordoba, Michaela Hanakova, Giovanni Zambrotta, Mariarita Sciumè, Stephen Booth, Raquel Nunes Rodrigues, Maria Vittoria Sacchi, Nicole García-Poutón, Juan-Alberto Martín-González, Sofya Khostelidi, Stefanie Gräfe, Laman Rahimli, Emanuele Ammatuna, Alessandro Busca, Paolo Corradini, Martin Hoenigl, Nikolai Klimko, Philipp Koehler, Antonio Pagliuca, Francesco Passamonti, Oliver A. Cornely, Livio Pagano

https://doi.org/10.3324/haematol.2022.280847

Letters to the Editor

The gut microbiome in patients with chronic lymphocytic leukemia (76 Online Views)

Tereza Faitová, Rebecka Svanberg, Caspar da Cunha-Bang, Emma E. Ilett, Mette Jørgensen, Marc Noguera-Julian, Roger Paredes, Cameron R. MacPherson, Carsten U. Niemann

https://doi.org/10.3324/haematol.2021.280455

A validated clinical-genetic score for assessing the risk of thrombosis in patients with COVID-19 receiving thromboprophylaxis (82 Online Views)

José Manuel Soria, Sergi Mojal, Angel Martinez-Perez, Francisco René Acosta, Sonia López, Sara Miqueleiz, Diana Rodriguez, Maria Angeles Quijada, Antonio Cardenas, Francisco Vidal, Angel Remacha, Rosa Maria Antonijoan, Juan Carlos Souto

https://doi.org/10.3324/haematol.2022.281068

May 5, 2022

Articles

Patient- and physician-reported pain after tyrosine kinase inhibitor discontinuation among patients with chronic myeloid leukemia (250 Online Views)

Kathryn E Flynn, Ehab Atallah, Li Lin, Neil P Shah, Richard T Silver, Richard A. Larson, Javier Panilla-Ibarz, James E. Thompson, Vivian G. Oehler, Jerald P. Radich, Vamsi Kota, Michael J Mauro, Charles A Schiffer, Jorge Cortes, Kevin P Weinfurt

https://doi.org/10.3324/haematol.2021.280377

Relapse of immune-mediated thrombotic thrombocytopenic purpura following mRNA COVID-19 vaccination: a prospective cohort study (294 Online Views)

Gaetano Giuffrida, Uros Markovic, Annalisa Condorelli, Marianna Calagna, Stephanie Grasso, Andrea Duminuco, Carla Riccobene, Angelo Curto Pelle, Guido Zanghi, Francesco Di Raimondo

https://doi.org/10.3324/haematol.2022.280702

Letters to the Editor

Deregulated JAK3 mediates growth advantage and hemophagocytosis in extranodal nasal-type natural killer/T cell lymphoma (201 Online Views)

Adrien Picod, Suella Martino, Pascale Cervera, Gregory Manuceau, Marc Arca, Monica Wittner, YanYan Zhang, He Liang, Florian Beghi, Eric Solary, Fawzia Louache, Paul Coppo

https://doi.org/10.3324/haematol.2021.280349

Pure erythroid leukemia is characterized by biallelic TP53 inactivation and abnormal p53 expression patterns in de novo and secondary cases (183 Online Views)

Hong Fang, Sa A. Wang, Joseph D. Khoury, Siba El Hussein, Do Hwan Kim, Mehrnoosh Tashakori, Zhenya Tang, Shaoying Li, Zhihong Hu, Fatima Zahra Jelloul, Keyur P. Patel, Timothy J. McDonnell, Tapan Kadia, L. Jeffrey Medeiros, Wei Wang

https://doi.org/10.3324/haematol.2021.280487

Beta adrenergic signaling regulates HSPC commitment and therapy sensitivity in multiple myeloma (174 Online Views)

Remya Nair, Vimal Subramaniam, Benjamin G. Barwick, Vikas A. Gupta, Shannon M. Matulis, Sagar Lonial, Lawrence H. Boise, Ajay K. Nooka, Kuzhali Muthumalaiappan, Mala Shanmugam

https://doi.org/10.3324/haematol.2022.280907

Apr 28, 2022

Editorials
Article

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B cell lymphomas (226 Online Views)

Cristina Lopez, Nikolai Schleussner, Stephan H. Bernhart, Kortine Kleinheinz, Stephanie Sungalee, Henrike L. Sczakiel, Helene Kretzmer, Umut H. Toprak, Selina Glaser, Rabea Wagener, Ole Ammerpohl, Susanne Bens, Maciej Giefing, Juan C. Gonzalez Sanchez, Gordana Apic, Daniel Hubschmann, Martin Janz, Markus Kreuz, Anja Mottok, Judith M. Muller, Julian Seufert, Steve Hoffmann, Jan O. Korbel, Robert B. Russell, Roland Schule, Lorenz Trumper, Wolfram Klapper, Bernhard Radlwimmer, Peter Lichter, Ralf Kuppers, Matthias Schlesner, Stephan Mathas, Reiner Siebert

https://doi.org/10.3324/haematol.2021.280005

Editorials

Editorials

Editorials
Article

Molecular characterisation and clinical outcome of B-cell precursor acute lymphoblastic leukaemia with IG-MYC rearrangement (258 Online Views)

Simon Bomken, Amir Enshaei, Edward C. Schwalbe, Aneta Mikulasova, Yunfeng Dai, Masood Zaka, Kent T.M. Fung, Matthew Bashton, Huezin Lim, Lisa Jones, Nefeli Karataraki, Emily Winterman, Cody Ashby, Andishe Attarbaschi, Yves Bertrand, Jutta Bradtke, Barbara Buldini, G.A. Amos Burke, Giovanni Cazzaniga, Gudrun Gohring, Hesta A. de Groot-Kruseman, Claudia Haferlach, Luca Lo Nigro, Mayur Parihar, Adriana Plesa, Emma Seaford, Edwin Sonneveld, Sabine Strehl, Vincent H.J. van der Velden, Vikki Rand, Stephen P. Hunger, Christine J. Harrison, Chris M. Bacon, Frederik W. van Delft, Mignon L. Loh, John Moppett, Josef Vormoor, Brian A. Walker, Anthony V. Moorman, Lisa J. Russell

https://doi.org/10.3324/haematol.2021.280557

Articles

Resistance to PI3κδ inhibitors in marginal zone lymphoma can be reverted by targeting the IL-6/PDGFRA axis (465 Online Views)

Alberto J. Arribas, Sara Napoli, Luciano Cascione, Giulio Sartori, Laura Barnabei, Eugenio Gaudio, Chiara Tarantelli, Afua Adjeiwaa Mensah, Filippo Spriano, Antonella Zucchetto, Francesca M Rossi, Andrea Rinaldi, Manuel Castro de Moura, Sandra Jovic, Roberta Bordone-Pittau, Alessandra Di Veroli, Anastasios Stathis, Gabriele Cruciani, Georg Stussi, Valter Gattei, Jennifer R Brown, Manel Esteller, Emanuele Zucca, Davide Rossi, Francesco Bertoni

https://doi.org/10.3324/haematol.2021.279957

Total late effect burden in long-term lymphoma survivors after high-dose therapy with autologous stem-cell transplant and its effect on health-related quality of life (588 Online Views)

Knut Smeland, Harald Holte, Unn-Merete Fagerli, Hanne Bersvendsen, Marianne J. Hjermstad, Jon H. Loge, Klaus Murbrach, Marianne D. Linnsund, Oystein Fluge, Jo S. Stenehjem, May B. Lund, Stein Kvaloy, Cecilie E. Kiserud

https://doi.org/10.3324/haematol.2021.280413

Phenotypic and functional characterization of the CD6-ALCAM T cell costimulatory pathway after allogeneic cell transplantation (315 Online Views)

Benedetta Rambaldi, Haesook T. Kim, Yohei Arihara, Takeru Asano, Carol Reynolds, Mariah Manter, Max Halpern, Augustine Weber, John Koreth, Corey Cutler, Mahasweta Gooptu, Sarah Nikiforow, Vincent T. Ho, Joseph H. Antin, Rizwan Romee, Jeanette Ampudia, Cherie Ng, Stephen Connelly, Robert J. Soiffer, Jerome Ritz

https://doi.org/10.3324/haematol.2021.280444

Erdheim-Chester disease: look it in the eye. An orbital MRI study (83 Online Views)

Julien Haroche, Yoram Gueniche, Damien Galanaud, Fleur Cohen-Aubart, Didier Dormont, Théophile Rousseau, Zahir Amoura, Valerie Touitou, Natalia Shor

https://doi.org/10.3324/haematol.2021.280510

Letters to the Editor

Low-dose TKI in patients with chronic myeloid leukemia: a retrospective study in China (100 Online Views)

Yilin Chen, Zelin Liu, Jing Zou, Danyu Wang, Wenjuan He, Li Meng, Fanjun Cheng, Yanli Zhang, Weiming Li

https://doi.org/10.3324/haematol.2022.280637

Copy number alterations define outcome in Philadelphia chromosome-positive acute lymphoblastic leukemia (146 Online Views)

Helena Hohtari, Niels Pallisgaard, Matti Kankainen, Pekka Ellonen, Oscar Brück, Timo Siitonen, Marjaana Säily, Marjatta Sinisalo, Marja Pyörälä, Maija Itälä-Remes, Perttu Koskenvesa, Erkki Elonen, Satu Mustjoki, Kimmo Porkka

https://doi.org/10.3324/haematol.2021.280578

Apr 21, 2022

Editorials
Article

The mutational landscape in chronic myelomonocytic leukemia and its impact on allogeneic hematopoietic cell transplantation outcomes: a Center for Blood and Marrow Transplantation Research (CIBMTR) analysis (1000 Online Views)

Matthew Mei, Raju Pillai, Soyoung Kim, Noel Estrada-Merly, Michelle Afkhami, Lixin Yang, Zhuo Meng, Muhammad Bilal Abid, Mahmoud Aljurf, Ulrike Bacher, Amer Beitinjaneh, Christopher Bredeson, Jean-Yves Cahn, Jan Cerny, Edward Copelan, Corey Cutler, Zachariah DeFilipp, Miguel Angel Diaz Perez, Nosha Farhadfar, César O. Freytes, Shahinaz M. Gadalla, Siddhartha Ganguly, Robert Peter Gale, Usama Gergis, Michael R. Grunwald, Betty K. Hamilton, Shahrukh Hashmi, Gerhard C. Hildebrandt, Hillard M. Lazarus, Mark Litzow, Reinhold Munker, Hemant S. Murthy, Sunita Nathan, Taiga Nishihori, Sagar S. Patel, David Rizzieri, Sachiko Seo, Mithun Vinod Shah, Melhem Solh, Leo F. Verdonck, Ravi Vij, Ronald M. Sobecks, Betul Oran, Bart L. Scott, Wael Saber, Ryotaro Nakamura

https://doi.org/10.3324/haematol.2021.280203

Editorials
Letter to the Editor

Crosstalk between β-catenin and WT1 signalling activity in acute myeloid leukemia (401 Online Views)

Megan Wagstaff, Olga Tsaponina, Gilian Caalim, Hayley Greenfield, Leanne Milton-Harris, Erika J Mancini, Allison Blair, Kate J Heesom, Alex Tonks, Richard L Darley, Stefan G Roberts, Rhys G Morgan

https://doi.org/10.3324/haematol.2021.280294

Articles

Evidence of protective effects of recombinant ADAMTS13* in humanized model for sickle cell disease (173 Online Views)

Paolo Rossato, Enrica Federti, Alessandro Matte, Helmut Glantschnig, Fabio Canneva, Maria Schuster, Sogue Coulibaly, Gerald Schrenk, Dirk Voelkel, Michael Dockal, Barbara Plaimauer, Immacolata Andolfo, Achille Iolascon, Hanspeter Rottensteiner, Herbert Gritsch, Friedrich Scheiflinger, Werner Hoellriegl, Lucia De Franceschi

https://doi.org/10.3324/haematol.2021.280233

Letters to the Editor

COVID-19 Infection in acute lymphoblastic leukemia over 15 months of the pandemic. A CAMPUS ALL report. (121 Online Views)

Sabina Chiaretti, Massimiliano Bonifacio, Roberta Agrippino, Fabio Giglio, Mario Annunziata, Antonio Curti, Maria Ilaria Del Principe, Prassede Salutari, Mariarita Sciumè, Mario Delia, Marco Armenio, Valentina Mancini, Antonino Mulè, Francesco Grimaldi, Giovanna Rege-Cambrin, Lidia Santoro, Federico Lussana, Patrizia Chiusolo, Crescenza Pasciolla, Anna Maria Scattolin, Marco Cerrano, Maria Ciccone, Marzia Defina, Fabio Forghieri, Carla Mazzone, Matteo Piccini, Felicetto Ferrara, Giovanni Pizzolo, Robin Foà

https://doi.org/10.3324/haematol.2021.280289

Hemostatic and protein C pathway dysfunction in the pathogenesis of experimental cerebral malaria (181 Online Views)

Niamh O'Regan, Kristina Gegenbauer, Eimear M. Gleeson, Kenji Fukudome, Jamie M. O'Sullivan, Clive Drakeford, Niall Dalton, Alain Chion, Teresa M. Brophy, Owen P. Smith, Roger J.S. Preston, James S. O'Donnell

https://doi.org/10.3324/haematol.2021.280450

A novel BCMA CAR-T-cell therapy with optimized human scFv for treatment of relapsed/refractory multiple myeloma: results from phase I clinical trials (454 Online Views)

Min Yang, Wenhao Zhang, Kang Yu, Peng Wang, Hua Jiang, Linjun Chen, Haitao Meng, Yiqin Weng, Rong Tao, Xin Huang, Chongyun Xing, Huamao Wang, Jiangbo Wan, Shasha Wang, Lihui Dai, Amanda Y. Hendrix, Jun Xiao, Wei Wang, Hong Ma, Siguo Hao, Jie Jin, Zonghai Li, Songfu Jiang

https://doi.org/10.3324/haematol.2022.280629

Case Reports

Apr 14, 2022

Editorials

Articles

Genomic determinants impacting the clinical outcome of mogamulizumab treatment for adult T-cell leukemia/lymphoma (273 Online Views)

Norio Tanaka, Seiichi Mori, Kazuma Kiyotani, Yuki Ota, Osamu Gotoh, Shigeru Kusumoto, Nobuaki Nakano, Youko Suehiro, Asahi Ito, Ilseung Choi, Eiichi Ohtsuka, Michihiro Hidaka, Kisato Nosaka, Makoto Yoshimitsu, Yoshitaka Imaizumi, Shinsuke Iida, Atae Utsunomiya, Tetsuo Noda, Hiroyoshi Nishikawa, Ryuzo Ueda, Takashi Ishida

https://doi.org/10.3324/haematol.2021.280352

Apr 7, 2022

Articles

Treatment-free remission in chronic myeloid leukemia patients treated front-line with nilotinib: 10-year follow-up of the GIMEMA CML 0307 study (399 Online Views)

Gabriele Gugliotta, Fausto Castagnetti, Massimo Breccia, Luciano Levato, Tamara Intermesoli, Mariella D'Adda, Marzia Salvucci, Fabio Stagno, Giovanna Rege-Cambrin, Mario Tiribelli, Bruno Martino, Monica Bocchia, Michele Cedrone, Elena Trabacchi, Francesco Cavazzini, Ferdinando Porretto, Federica Sorà, Maria Pina Simula, Francesco Albano, Simona Soverini, Robin Foà, Fabrizio Pane, Michele Cavo, Giuseppe Saglio, Michele Baccarani, Gianantonio Rosti

https://doi.org/10.3324/haematol.2021.280175

Iron- and erythropoietin-resistant anemia in a spontaneous breast cancer mouse model (272 Online Views)

Nuria Fabregas Bregolat, Maja Ruetten, Milene Costa da Silva, Mostafa A. Aboouf, Hyrije Ademi, Nadine von Büren, Julia Armbruster, Martina Stirn, Sandro Altamura, Oriana Marques, Josep M. Monné Rodriguez, Victor J. Samillan, Rashim Pal Singh, Ben Wielockx, Martina U. Muckenthaler, Max Gassmann, Markus Thiersch

https://doi.org/10.3324/haematol.2022.280732

The deglycosylated form of 1E12 inhibits platelet activation and prothrombotic effects induced by VITT antibodies (269 Online Views)

Caroline Vayne, Raghavendra Palankar, Sandra Billy, Stefan Handtke, Thomas Thiele, Charlotte Cordonnier, Claire Pouplard, Andreas Greinacher, Yves Gruel, Jérôme Rollin

https://doi.org/10.3324/haematol.2021.280251

Case Reports

Mar 31, 2022

Articles

Final analysis of the phase 3 non-inferiority COLUMBA study of subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma (665 Online Views)

Saad Z. Usmani, Hareth Nahi, Wojciech Legiec, Sebastian Grosicki, Vladimir Vorobyev, Ivan Spicka, Vania Hungria, Sibirina Korenkova, Nizar J. Bahlis, Max Flogegard, Joan Bladé, Philippe Moreau, Martin Kaiser, Shinsuke Iida, Jacob Laubach, Hila Magen, Michele Cavo, Cyrille Hulin, Darrell White, Valerio De Stefano, Kristen Lantz, Lisa O’Rourke, Christoph Heuck, Maria Delioukina, Xiang Qin, Ivo Nnane, Ming Qi, Maria-Victoria Mateos

https://doi.org/10.3324/haematol.2021.279459

Glycolytic enzyme PFKFB3 determines bone marrow endothelial progenitor cell damage post chemotherapy and irradiation (404 Online Views)

Zhong-Shi Lyu, Shu-Qian Tang, Tong Xing, Yang Zhou, Meng Lv, Hai-Xia Fu, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Hsiang-Ying Lee, Yuan Kong, Xiao-Jun Huang

https://doi.org/10.3324/haematol.2021.279756

Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia: phenotypes, risk factors and genotypes (497 Online Views)

Stavroula Anastasopoulou, Rikke Linnemann Nielsen, Bodil Als-Nielsen, Joanna Banerjee, Mats A. Eriksson, Marianne Helenius, Mats M. Heyman, Inga Maria Johannsdottir, Olafur Gisli Jonsson, Stuart MacGregor, Marion K. Mateos, Chelsea Mayoh, Sirje Mikkel, Ida Hed Myrberg, Riitta Niinimäki, Kjeld Schmiegelow, Mervi Taskinen, Goda Vaitkeviciene, Anna Warnqvist, Benjamin Wolthers, Arja Harila-Saari, Susanna Ranta

https://doi.org/10.3324/haematol.2021.280016

Preclinical evaluation and structural optimization of anti-BCMA CAR to target multiple myeloma (621 Online Views)

Ortal Harush, Nathalie Asherie, Shlomit Kfir-Erenfeld, Galit Adler, Tilda Barliya, Miri Assayag, Moshe E. Gatt, Polina Stepensky, Cyrille J. Cohen

https://doi.org/10.3324/haematol.2021.280169

Fc galactosylation of anti-platelet hIgG1 alloantibodies enhance complement activation on platelets (355 Online Views)

Thijs L.J. van Osch, Janita J. Oosterhoff, Arthur E. H. Bentlage, Jan Nouta, Carolien A. M. Koeleman, Dionne M. Geerdes, Juk Yee Mok, Sebastiaan Heidt, Arend Mulder, Wim J. E. van Esch, Rick Kapur, Leendert Porcelijn, C. Ellen van der Schoot, Masja de Haas, Manfred Wuhrer, Jan Voorberg, Gestur Vidarsson

https://doi.org/10.3324/haematol.2021.280493

Letters to the Editor

Preclinical evaluation of the preservation of red blood cell concentrates by hypoxic storage technology for transfusion in sickle cell disease (163 Online Views)

Laura Bencheikh, Kim-Anh Nguyen, Philippe Chadebech, Laurent Kiger, Gwellaouen Bodivit, Alicia Jouard, Sadaf Pakdaman, Sandia Adypagavane, Etienne Audureau, Khouloud Tebbakha, Thibaut Bocquet, Blandine Mignen, Nicolas Hebert, Marion Seguin, France Pirenne, Samuel Sowemimo-Coker, Andrew Dunham, Pablo Bartolucci

https://doi.org/10.3324/haematol.2021.279721

The use of hydroxyurea pretreatment in chronic myeloid leukemia in the current tyrosine kinase inhibitor era (162 Online Views)

Camille C.B. Kockerols, Inge Geelen, Mark-David Levin, Jeroen J.W.M. Janssen, Avinash G. Dinmohamed, Mels Hoogendoorn, Jan J. Cornelissen, Peter E. Westerweel

https://doi.org/10.3324/haematol.2021.280501

Full versus prophylactic-intermediate doses of anticoagulants in COVID-19: a meta-analysis (234 Online Views)

Lorenzo Loffredo, Augusto Di Castelnuovo, Giovanni Alfonso Chiariello, Pasquale Pignatelli, Francesco Violi

https://doi.org/10.3324/haematol.2022.280652

Case Reports

Mar 24, 2022

Editorials
Article

Autologous stem cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study (719 Online Views)

Alejandro Martín García-Sancho, Monica Bellei, Miriam López-Parra, Giuseppe Gritti, María Cortés, Silvana Novelli, Carlos Panizo, Luigi Petrucci, Antonio Gutiérrez, Ivan Dlouhy, Mariana Bastos-Oreiro, Juan M. Sancho, María J. Ramírez, José M. Moraleda, Estrella Carrillo, Ana I. Jiménez-Ubieto, Isidro Jarque, Lorella Orsucci, Estefanía García-Torres, Carlos Montalbán, Anna Dodero, Reyes Arranz, Natalia de las Heras, María J. Pascual, Javier López-Jiménez, Michelle Spina, Alessandro Re, Sonia González de Villambrosia, Sabela Bobillo, Massimo Federico, Dolores Caballero

https://doi.org/10.3324/haematol.2021.279426

Letters to the Editor

Cell-free DNA sequencing as a potential screening tool for phase I targeted treatment in refractory/relapse diffuse large B cell lymphoma (307 Online Views)

Cyril Quivoron, Anthony Tarabay, Jean-Marie Michot, Arnaud Pagès, Hélène Lecourt, Anne Aupérin, Alina Danu, Julien Lazarovici, Julien Rossignol, David Ghez, Peggy Dartigues, Véronique Vergé, Christophe Massard, Valérie Camara-Clayette, Vincent Ribrag, Clémentine Sarkozy

https://doi.org/10.3324/haematol.2021.280464

Mar 17, 2022

Editorials
Article

Clinical relevance of an objective – limit of detection – limit of quantification - based flow cytometry approach for measurable residual disease assessment in acute myeloid leukemia. A post-hoc analysis of the GIMEMA AML1310 trial. (329 Online Views)

Francesco Buccisano, Raffaele Palmieri, Alfonso Piciocchi, Valentina Arena, Luca Maurillo, Maria-Ilaria Del Principe, Giovangiacinto Paterno, Maria-Antonietta Irno-Consalvo, Tiziana Ottone, Mariadomenica Divona, Consuelo Conti, Daniela Fraboni, Serena Lavorgna, William Arcese, Maria Teresa Voso, Adriano Venditti

https://doi.org/10.3324/haematol.2021.279777

Editorials

Articles

Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets (285 Online Views)

Robert Wolf, Sophie Grammbauer, Raghavendra Palankar, Céline Tolksdorf, Eileen Moritz, Andreas Böhm, Mahmoud Hasan, Annika Hafkemeyer, Andreas Greinacher, Mladen V. Tzvetkov, Bernhard H. Rauch, Gabriele Jedlitschky

https://doi.org/10.3324/haematol.2021.279761

Syndromes predisposing to leukemia are a major cause of inherited cytopenias in children (494 Online Views)

Oded Gilad, Orly Dgany, Sharon Noy-Lotan, Tanya Krasnov, Joanne Yacobovich, Ron Rabinowicz, Tracie Goldberg, Amir A. Kuperman, Abed Abu-Quider, Hagit Miskin, Noa Kapelushnik, Noa Mandel-Shorer, Shai Shimony, Dan Harlev, Tal Ben-Ami, Etai Adam, Carina Levin, Shraga Aviner, Ronit Elhasid, Sivan Berger-Achituv, Lilach Chaitman-Yerushalmi, Yona Kodman, Nino Oniashvilli, Michal Hameiri-Grosman, Shai Izraeli, Hannah Tamary, Orna Steinberg-Shemer

https://doi.org/10.3324/haematol.2021.280116

Letters to the Editor

BRAFV600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis (280 Online Views)

Ko Kudo, Tsutomu Toki, Rika Kanezaki, Tatsuhiko Tanaka, Takuya Kamio, Tomohiko Sato, Shinya Sasaki, Masaru Imamura, Chihaya Imai, Kumiko Ando, Harumi Kakuda, Takehiko Doi, Hiroshi Kawaguchi, Masahiro Irie, Yoji Sasahara, Akihiro Tamura, Daiichiro Hasegawa, Yosuke Itakura, Kenichiro Watanabe, Kenichi Sakamoto, Yoko Shioda, Motohiro Kato, Kazuko Kudo, Reiji Fukano, Atsushi Sato, Hiroshi Yagasaki, Hirokazu Kanegane, Itaru Kato, Katsutsugu Umeda, Souichi Adachi, Tatsuki Kataoka, Akira Kurose, Atsuko Nakazawa, Kiminori Terui, Etsuro Ito

https://doi.org/10.3324/haematol.2021.279857

Prolonged viral replication in patients with hematologic malignancies hospitalized with COVID-19 (353 Online Views)

Carolina Garcia-Vidal, Pedro Puerta-Alcalde, Aina Mateu, Genoveva Cuesta-Chasco, Fernanda Meira, Carlos Lopera, Patricia Monzo, Marta Santos-Bravo, Gerard Duenas, Mariana Chumbita, Nicole Garcia-Pouton, Anna Gaya, Marta Bodro, Sabina Herrera, Mar Mosquera, Francesc Fernandez-Aviles, Jose Antonio Martinez, Josep Mensa, Eva Gine, Maria Angeles Marcos, Alex Soriano

https://doi.org/10.3324/haematol.2021.280407

Treatment emergent peripheral neuropathy in the CASSIOPEIA trial (213 Online Views)

Cathelijne Fokkema, Phillipe Moreau, Bronno van der Holt, Jérôme Lambert, Mark van Duin, Ruth Wester, Joost L.M. Jongen, Pieter A. van Doorn, Sophie Godet, Kon Siong Jie, Olivier Fitoussi, Michel Delforge, Awa Keita-Manta, Odile Luycx, Tom Cupedo, Niels W.C.J. van de Donk, Sonja Zweegman, Jessica T. Vermeulen, Pieter Sonneveld, Annemiek Broijl

https://doi.org/10.3324/haematol.2021.280567

Mar 10, 2022

Editorials
Article

The IL32/BAFF axis supports prosurvival dialogs in the lymphoma ecosystem and is disrupted by NIK inhibition (381 Online Views)

Salomé Decombis, Antonin Papin, Céline Bellanger, Clara Sortais, Christelle Dousset, Yannick Le Bris, Thiphanie Riveron, Stéphanie Blandin, Philippe Hulin, Benoit Tessoulin, Mathieu Rouel, Steven Le Gouill, Agnès Moreau-Aubry, Catherine Pellat-Deceunynck, David Chiron

https://doi.org/10.3324/haematol.2021.279800

Articles

Extracellular vesicles mediate the communication between multiple myeloma and bone marrow microenvironment in a NOTCH dependent way (478 Online Views)

Domenica Giannandrea, Natalia Platonova, Michela Colombo, Mara Mazzola, Valentina Citro, Raffaella Adami, Filippo Maltoni, Silvia Ancona, Vincenza Dolo, Ilaria Giusti, Andrea Basile, Anna Pistocchi, Laura Cantone, Valentina Bollati, Lavinia Casati, Elisabetta Calzavara, Mauro Turrini, Elena Lesma, Raffaella Chiaramonte

https://doi.org/10.3324/haematol.2021.279716

High tumor burden before blinatumomab has a negative impact on the outcome of adult patients with B-cell precursor acute lymphoblastic leukemia. A real-world study by the GRAALL (456 Online Views)

Aurelie Cabannes-Hamy, Eolia Brissot, Thibaut Leguay, Francoise Huguet, Patrice Chevallier, Mathilde Hunault, Martine Escoffre-Barbe, Thomas Cluzeau, Marie Balsat, Stephanie Nguyen, Florence Pasquier, Magda Alexis, Veronique Lheritier, Cedric Pastoret, Eric Delabesse, Emmanuelle Clappier, Herve Dombret, Nicolas Boissel

https://doi.org/10.3324/haematol.2021.280078

Letters to the Editor

Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria (318 Online Views)

Jun-ichi Nishimura, Kiyoshi Ando, Masayoshi Masuko, Hideyoshi Noji, Yoshikazu Ito, Jiri Mayer, Laimonas Griskevicius, Christoph Bucher, Florian Müllershausen, Peter Gergely, Izabela Rozenberg, Anna Schubart, Raghav Chawla, Jean-Michel Rondeau, Michael Roguska, Igor Splawski, Mark T. Keating, Leslie Johnson, Rambabu Danekula, Morten Bagger, Yoko Watanabe, Börje Haraldsson, Yuzuru Kanakura

https://doi.org/10.3324/haematol.2020.265868

Mar 3, 2022

Review Articles

Articles

Rituximab in addition to LMB-based chemotherapy regimen in children and adolescents with primary mediastinal large B-cell lymphoma: results of the French LMB2001 prospective study. (531 Online Views)

Marie Emilie Dourthe, Aurélie Phulpin, Anne Auperin, Jacques Bosq, Marie-Laure Couec, Peggy Dartigues, Stéphane Ducassou, Nathalie Garnier, Stéphanie Haouy, Thierry Leblanc, Amaury Leruste, Catherine Paillard, Charlotte Rigaud, Mathieu Simonin, Catherine Patte, Véronique Minard-Colin

https://doi.org/10.3324/haematol.2021.280257

Letters to the Editor

CHIP-related epigenetic age acceleration correlates with CHIP clone size in patients with high morbidity (332 Online Views)

Jasper David Feldkamp, Valentin Max Vetter, Christopher Maximilian Arends, Tonio Johannes Lukas Lang, Lars Bullinger, Frederik Damm, Ilja Demuth, Mareike Frick

https://doi.org/10.3324/haematol.2021.280021

Decitabine salvage for Tumor Protein P53-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy (440 Online Views)

Francesca Ferraro, Agata Gruszczynska, Marianna B. Ruzinova, Christopher A. Miller, Mary Elizabeth Percival, Geoffrey L. Uy, Iskra Pusic, Meagan A. Jacoby, Mathew J. Christopher, Miriam Y. Kim, Peter Westervelt, Amanda F. Cashen, Mark A. Schroeder, John F. DiPersio, Camille N. Abboud, Lukas D. Wartman, Feng Gao, Daniel C. Link, Timothy J. Ley, John S. Welch

https://doi.org/10.3324/haematol.2021.280153

Tricuspid-valve regurgitant jet velocity as a risk factor for death in β-Thalassemia (177 Online Views)

Giorgio Derchi, Khaled M. Musallam, Valeria Maria Pinto, Giovanna Graziadei, Marianna Giuditta, Susanna Barella, Raffaella Origa, Gavino Casu, Annamaria Pasanisi, Filomena Longo, Maddalena Casale, Roberta Miceli, Pierluigi Merella, Barbara Gianesin, Pietro Ameri, Immacolata Tartaglione, Silverio Perrotta, Antonio Piga, Maria Domenica Cappellini, Gian Luca Forni

https://doi.org/10.3324/haematol.2021.280389

Reduced immunogenicity of a third COVID-19 vaccination among recipients of allogeneic haematopoietic stem cell transplantation (304 Online Views)

Sigrun Einarsdottir, Anna Martner, Malin Nicklasson, Hanna Grauers Wiktorin, Mohammad Arabpour, Andreas Törnell, Krista Vaht, Jesper Waldenström, Johan Ringlander, Tomas Bergström, Mats Brune, Kristoffer Hellstrand, Per Ljungman, Martin Lagging

https://doi.org/10.3324/haematol.2021.280494

Case Reports

Comments
Comment

Intricacies of GATA-ca, Continued (187 Online Views)

Christine Lomas-Francis, Elizabeth F. Stone, Connie M. Westhoff, Patricia A. Shi

https://doi.org/10.3324/haematol.2022.280876

Feb 24, 2022

Editorials
Article

Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia (697 Online Views)

Amos Tuval, Yardena Brilon, Hadas Azogy, Yoni Moskovitz, Dena Leshkowitz, Tomer M Salame, Mark D Minden, Perry Tal, Varda Rotter, Moshe Oren, Nathali Kaushansky, Liran I Shlush

https://doi.org/10.3324/haematol.2021.280329

Articles

Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia (501 Online Views)

Shiying Silvia Zheng, Zohra Ahmadi, Halina Hoi Laam Leung, Rose Wong, Feng Yan, Jose Sail Perdomo, Beng Hock Chong

https://doi.org/10.3324/haematol.2021.279751

Letters to the Editor

Risk of hepatitis B virus reactivation in chronic lymphocytic leukemia patients receiving ibrutinib with or without antiviral prophylaxis. A retrospective multicentric GIMEMA study (544 Online Views)

Idanna Innocenti, Gianluigi Reda, Andrea Visentin, Marta Coscia, Marina Motta, Roberta Murru, Riccardo Moia, Massimo Gentile, Elsa Pennese, Francesca Maria Quaglia, Francesco Albano, Ramona Cassin, Marina Deodato, Claudia Ielo, Anna Maria Frustaci, Alfonso Piciocchi, Arianna Rughini, Valentina Arena, Daniela Di Sevo, Annamaria Tomasso, Francesco Autore, Giovanni Del Poeta, Lydia Scarfò, Francesca Romana Mauro, Alessandra Tedeschi, Livio Trentin, Maurizio Pompili, Robin Foà, Paolo Ghia, Antonio Cuneo, Luca Laurenti

https://doi.org/10.3324/haematol.2021.280325

Diagnosis of acute promyelocytic leukemia based on routine biological parameters using machine learning (363 Online Views)

Estelle Cheli, Simon Chevalier, Olivier Kosmider, Marion Eveillard, Nicolas Chapuis, Adriana Plesa, Maël Heiblig, Lydie Andre, Jenny Pouget, Pascal Mossuz, Olivier Theisen, Vincent Alcazer, Dan Gugenheim, Nicolas Autexier, Pierre Sujobert

https://doi.org/10.3324/haematol.2022.280406

Feb 17, 2022

Editorials
Article

The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of acute myeloid leukemias (642 Online Views)

Rosa Paolillo, Mathias Boulanger, Pierre Gâtel, Ludovic Gabellier, Marion De Toledo, Denis Tempé, Rawan Hallal, Dana Akl, Jérôme Moreaux, Hayeon Baik, Elise Gueret, Christian Recher, Jean-Emmanuel Sarry, Guillaume Cartron, Marc Piechaczyk, Guillaume Bossis

https://doi.org/10.3324/haematol.2021.279889

Articles

Humoral immune-depression following autologous stem cell transplantation is a marker of prolonged response duration in patients with mantle cell lymphoma (543 Online Views)

Louise Bouard, Benoit Tessoulin, Catherine Thieblemont, Kamal Bouabdallah, Thomas Gastinne, Lucie Oberic, Sylvain Carras, Caroline Delette, Olivier Casasnovas, Caroline Dartigeas, Victoria Cacheux, Sibylle Masse, Olivier Hermine, Steven Le Gouill

https://doi.org/10.3324/haematol.2021.279561

Increased visceral fat distribution and body composition impact cytokine release syndrome onset and severity after CD19 CAR-T in advanced B-cell malignancies (1039 Online Views)

David M. Cordas dos Santos, Kai Rejeski, Michael Winkelmann, Lian Liu, Paul Trinkner, Sophie Günther, Veit L. Bücklein, Viktoria Blumenberg, Christian Schmidt, Wolfgang G. Kunz, Michael von Bergwelt-Baildon, Sebastian Theurich, Marion Subklewe

https://doi.org/10.3324/haematol.2021.280189

Letters to the Editor

The highly selective Bruton tyrosine kinase inhibitor acalabrutinib leaves macrophage phagocytosis intact (458 Online Views)

Jonathan J. Pinney, Sara K. Blick-Nitko, Andrea M. Baran, Derick R. Peterson, Hannah E. Whitehead, Raquel Izumi, Veerendra Munugalavadla, Karl R. Van DerMeid, Paul M. Barr, Clive S. Zent, Michael R. Elliott, Charles C. Chu

https://doi.org/10.3324/haematol.2021.279560

Complement C1s inhibition with sutimlimab results in durable response in cold agglutinin disease: CARDINAL study 1-year interim follow-up results (1094 Online Views)

Alexander Roth, Wilma Barcellini, Shirley D’Sa, Yoshitaka Miyakawa, Catherine M. Broome, Marc Michel, David J. Kuter, Bernd Jilma, Tor Henrik Anderson Tvedt, Ilene C. Weitz, Parija Patel, Xiaoyu Jiang, Caroline Reuter, Jun Su, Frank Shafer, Michelle Lee, Sigbjorn Berentsen

https://doi.org/10.3324/haematol.2021.279812

Vaccine-induced immune thrombotic thrombocytopenia: a possible pathogenetic role of ChAdOx1 nCoV-19 vaccine encoded soluble SARS-CoV-2 spike protein (396 Online Views)

Manuela De Michele, Paola Piscopo, Alessio Crestini, Roberto Rivabene, Giulia d’Amati, Martina Leopizzi, Lucia Stefanini, Fabio Pulcinelli, Antonio Chistolini, Marta Iacobucci, Oscar G. Schiavo, Irene Berto, Ettore Nicolini, Luca Petraglia, Maria Teresa Di Mascio, Danilo Toni

https://doi.org/10.3324/haematol.2021.280180

All-oral triplet combination with ixazomib, lenalidomide, and dexamethasone in newly diagnosed transplant-eligible myeloma patients: final results of the phase 2 IFM study 2013-06 (499 Online Views)

Cyrille Touzeau, Aurore Perrot, Murielle Roussel, Lionel Karlin, Lotfi Benboubker, Caroline Jacquet, Mohamad Mohty, Thierry Facon, Salomon Manier, Marie-Lorraine Chretien, Mourad Tiab, Cyrille Hulin, Xavier Leleu, Hervé Avet Loiseau, Thomas Dejoie, Lucie Planche, Michel Attal, Philippe Moreau

https://doi.org/10.3324/haematol.2021.280394

Feb 10, 2022

Articles

A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells in vitro and in vivo (671 Online Views)

Lucas C. M. Arruda, Arwen Stikvoort, Melanie Lambert, Liqing Jin, Laura Sanchez Rivera, Renato M. P. Alves, Tales Rocha de Moura, Carsten Mim, Sören Lehmann, Rebecca Axelsson-Robertson, John E. Dick, Jonas Mattsson, Björn Önfelt, Mattias Carlsten, Michael Uhlin

https://doi.org/10.3324/haematol.2021.279486

Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis (498 Online Views)

Stefania Momi, Jessica Canino, Mauro Vismara, Luca Galgano, Emanuela Falcinelli, Giuseppe Guglielmini, Giulia Ciarrocca Taranta, Gianni Francesco Guidetti, Paolo Gresele, Mauro Torti, Ilaria Canobbio

https://doi.org/10.3324/haematol.2021.279703

Outcome of relapsed or refractory acute B-lymphoblastic leukemia patients and BCR-ABL positive blast cell crisis of B-lymphoid lineage with extramedullary disease receiving inotuzumab ozogamicin (521 Online Views)

Sabine Kayser, Chiara Sartor, Marlise R. Luskin, Jonathan Webster, Fabio Giglio, Nydia Panitz, Andrew M. Brunner, Matthias Fante, Christoph Lutz, Daniel Wolff, Anthony D. Ho, Mark J. Levis, Richard F. Schlenk, Cristina Papayannidis

https://doi.org/10.3324/haematol.2021.280433

Feb 3, 2022

Editorials
Article

Temsirolimus combined with cyclophosphamide and etoposide for pediatric patients with relapsed/refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium trial (TACL 2014-001) (438 Online Views)

Sarah K. Tasian, Lewis B. Silverman, James A. Whitlock, Richard Sposto, Joseph P. Loftus, Eric S. Schafer, Kirk R. Schultz, Raymond J. Hutchinson, Paul S. Gaynon, Etan Orgel, Caroline M. Bateman, Todd M. Cooper, Theodore W. Laetsch, Maria Luisa Sulis, Yueh-Yun Chi, Jemily Malvar, Alan S. Wayne, Susan R. Rheingold

https://doi.org/10.3324/haematol.2021.279520

Editorials
Article

YTHDF3 modulates hematopoietic stem cells by recognizing RNA m6A modification on Ccnd1 (757 Online Views)

Xiaofei Zhang, Tingting Cong, Lei Wei, Bixi Zhong, Xiaowo Wang, Jin Sun, Shuxia Wang, Meng Michelle Xu, Ping Zhu, Hong Jiang, Jianwei Wang

https://doi.org/10.3324/haematol.2021.279739

Jan 27, 2022

Editorials
Article

A real-world based score to predict early death in acute promyelocytic leukemia (359 Online Views)

Albin Österroos, Tânia Maia, Anna Eriksson, Martin Jädersten, Vladimir Lazarevic, Lovisa Wennström, Petar Antunovic, Jörg Cammenga, Stefan Deneberg, Fryderyk Lorenz, Lars Möllgård, Bertil Uggla, Emma Ölander, Eliana Aguiar, Fernanda Trigo, Martin Höglund, Gunnar Juliusson, Sören Lehmann

https://doi.org/10.3324/haematol.2021.280093

Articles

Syntaxin 5 determines Weibel-Palade body size and Von Willebrand factor secretion by controlling Golgi architecture (498 Online Views)

Marije Kat, Ellie Karampini, Arie J. Hoogendijk, Petra E. Bürgisser, Aat A. Mulder, Floris P.J. van Alphen, Jenny Olins, Dirk Geerts, Maartje van den Biggelaar, Coert Margadant, Jan Voorberg, Ruben Bierings

https://doi.org/10.3324/haematol.2021.280121

Programmed cell death ligand 1 expression in aggressive pediatric non-Hodgkin lymphomas: frequency, genetic mechanisms, and clinical significance (449 Online Views)

Kevin E. Fisher, Lizmery S. Ferguson, Amy M. Coffey, Brian Y. Merritt, Jonathan L. Curry, Andrea N. Marcogliese, Angela M. Major, Kala Y. Kamdar, Dolores H. Lopez-Terrada, Choladda V. Curry

https://doi.org/10.3324/haematol.2021.280342

Case Reports

Occurrence of a paroxysmal nocturnal hemoglobinuria clone in an essential thrombocythemia: a link between PIGV and MPL (353 Online Views)

Alexej Knaus, François Vergez, Cédric Garcia, Hartmut Engels, Hela Hundertmark, David Ribes, Laetitia Largeaud, Suzanne Tavitian, Bernard Payrastre, Peter Krawitz, Stanislas Faguer, Agnes Ribes

https://doi.org/10.3324/haematol.2021.279804

Jan 20, 2022

Articles

Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities (762 Online Views)

Nicola Giesen, Nagarajan Paramasivam, Umut H. Toprak, Daniel Huebschmann, Jing Xu, Sebastian Uhrig, Mehmet Samur, Stella Bähr, Martina Fröhlich, Sadaf S. Mughal, Elias K. Mai, Anna Jauch, Carsten Müller-Tidow, Benedikt Brors, Nikhil Munshi, Hartmut Goldschmidt, Niels Weinhold, Matthias Schlesner, Marc S. Raab

https://doi.org/10.3324/haematol.2021.279360

Jan 13, 2022

Editorials
Article

First-line treatment of chronic lymphocytic leukemia with ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab: final analysis of the randomized, phase 3 iLLUMINATE trial (1511 Online Views)

Carol Moreno, Richard Greil, Fatih Demirkan, Alessandra Tedeschi, Bertrand Anz, Loree Larratt, Martin Simkovic, Jan Novak, Vladimir Strugov, Devinder Gill, John G. Gribben, Kevin Kwei, Sandra Dai, Emily Hsu, James P. Dean, Ian W. Flinn

https://doi.org/10.3324/haematol.2021.279012

Editorials

Editorials
Article

Clinical relevance of proteomic profiling in de novo pediatric acute myeloid leukemia: a Children’s Oncology Group study (610 Online Views)

Fieke W. Hoff, Anneke D. van Dijk, Yihua Qiu, Chenyue W. Hu, Rhonda E. Ries, Andrew Ligeralde, Gaye N. Jenkins, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Amina A. Qutub, Eveline S.J.M. de Bont, Terzah M. Horton, Steven M. Kornblau

https://doi.org/10.3324/haematol.2021.279672

Articles

Sorting Nexin 24 is required for α-granule biogenesis and cargo delivery in megakaryocytes (533 Online Views)

Joanne Lacey, Simon J. Webster, Paul R. Heath, Chris J. Hill, Lucinda Nicholson-Goult, Bart E. Wagner, Abdullah O. Khan, Neil V. Morgan, Michael Makris, Martina E. Daly

https://doi.org/10.3324/haematol.2021.279636

Oncogenic TYK2P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade (528 Online Views)

Katharina Woess, Sabine Macho-Maschler, Dorette S. van Ingen Schenau, Miriam Butler, Caroline Lassnig, Daniel Valcanover, Andrea Poelzl, Katrin Meissl, Barbara Maurer, Tania Brandstoetter, Claus Vogl, Anna Koren, Stefan Kubicek, Anna Orlova, Richard Moriggl, Birgit Strobl, Veronika Sexl, Frank N. van Leeuwen, Roland P. Kuiper, Mathias Mueller

https://doi.org/10.3324/haematol.2021.279848

Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS (1053 Online Views)

Cho Mar Myint Wai, Shangying Chen, The Phyu, Shuangyi Fan, Sai Mun Leong, Wenning Zheng, Louis Ching Yi Low, Shoa-Nian Choo, Chi-Kuen Lee, Tae-Hoon Chung, Kenneth Hon Kim Ban, Soumita Ghosh, Stefanus Lie, Seiichi Kato, Shigeo Nakamura, Emiko Takahashi, Young-Hyeh Ko, Joseph D. Khoury, Shih-Sung Chuang, Rex K.H. Au-Yeung, Soo-Yong Tan, Soon-Thye Lim, Choon-Kiat Ong, Yong-Howe Ho, Li Mei Poon, Sanjay de Mel, Anand D. Jeyasekharan, Wee-Joo Chng, Franziska Otto, Leticia Quintanilla-Martinez, Federica Zanardi, Fabio Iannelli, Claudio Tripodo, Jason J. Pitt, Siok-Bian Ng

https://doi.org/10.3324/haematol.2021.280003

Dec 30, 2021

Editorials
Letter to the Editor

Outcomes of refractory or relapsed Hodgkin lymphoma patients with post-autologous stem cell transplantation brentuximab vedotin maintenance: a French multicenter observational cohort study (858 Online Views)

Amira Marouf, Anne Segolene Cottereau, Salim Kanoun, Paul Deschamps, Michel Meignan, Patricia Franchi, David Sibon, Clara Antoine, Thomas Gastinne, Cecile Borel, Mohammad Hammoud, Guillaume Sicard, Romane Gille, Doriane Cavalieri, Aspasia Stamatoullas, Lauriane Filliatre-Clement, Julien Lazarovici, Adrien Chauchet, Luc-Matthieu Fornecker, Sandy Amorin, Mathieu Rocquet, Nicole Raus, Barbara Burroni, Marie Therese Rubio, Didier Bouscary, Philippe Quittet, Rene Olivier Casasnovas, Pauline Brice, Herve Ghesquieres, Jérôme Tamburini, Benedicte Deau

https://doi.org/10.3324/haematol.2021.279564

Dec 23, 2021

Articles

Rational drug combinations with CDK4/6 inhibitors in acute lymphoblastic Leukemia (788 Online Views)

Karen L. Bride, Hai Hu, Anastasia Tikhonova, Tori J. Fuller, Tiffaney L. Vincent, Rawan Shraim, Marilyn M. Li, William L. Carroll, Elizabeth A. Raetz, Iannis Aifantis, David T. Teachey

https://doi.org/10.3324/haematol.2021.279410

Dec 16, 2021

Articles

Antibody response after vaccination against SARS-CoV-2 in adults with haematological malignancies: a systematic review and meta-analysis (2273 Online Views)

Nico Gagelmann, Francesco Passamonti, Christine Wolschke, Radwan Massoud, Christian Niederwieser, Raissa Adjallé, Barbara Mora, Francis Ayuk, Nicolaus Kröger

https://doi.org/10.3324/haematol.2021.280163

Dec 2, 2021

Articles

The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements (521 Online Views)

Sarah Grasedieck, Ariene Cabantog, Liam MacPhee, Junbum Im, Christoph Ruess, Burcu Demir, Nadine Sperb, Frank G. Rücker, Konstanze Döhner, Tobias Herold, Jonathan R. Pollack, Lars Bullinger, Arefeh Rouhi, Florian Kuchenbauer

https://doi.org/10.3324/haematol.2021.276048

Nov 25, 2021

Editorials
Letter to the Editor

Editorials
Article

The von Willebrand Factor A-1 domain binding aptamer BT200 elevates plasma levels of VWF and Factor VIII: a first-in-human trial (529 Online Views)

Katarina D. Kovacevic, Jürgen Grafeneder, Christian Schörgenhofer, Georg Gelbenegger, Gloria Gager, Christa Firbas, Peter Quehenberger, Petra Jilma-Stohlawetz, Andrea Bileck, Shuhao Zhu, James C. Gilbert, Martin Beliveau, Bernd Jilma, Ulla Derhaschnig

https://doi.org/10.3324/haematol.2021.279948

Nov 18, 2021

Editorials
Letter to the Editor

A third anti-SARS-Cov2 mRNA dose does not overcome the pejorative impact of anti-CD20 therapy and/or low immunoglobulin levels in patients with lymphoma or chronic lymphocytic leukemia (548 Online Views)

Milena Kohn, Marc Delord, Maureen Chbat, Amina Guemriche, Fatiha Merabet, Anne-Laure Roupie, Naelle Lombion, Hassan Farhat, Thomas Longval, Aurélie Cabannes-Hamy, Juliette Lambert, Stéphanie Marque-Juillet, Victoria Raggueneau, Jennifer Osman, Marc Spentchian, Sophie Rigaudeau, Philippe Rousselot, Caroline Besson

https://doi.org/10.3324/haematol.2021.280026

Articles

Genetic and genomic analysis of acute lymphoblastic leukaemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials (1107 Online Views)

Thomas Creasey, Emilio Barretta, Sarra L. Ryan, Ellie Butler, Amy A. Kirkwood, Daniel Leongamornlert, Elli Papaemmanuil, Pip Patrick, Laura Clifton-Hadley, Bela Patel, Tobias Menne, Andrew K. McMillan, Christine J. Harrison, Clare J. Rowntree, Nick Morley, David I. Marks, Adele K. Fielding, Anthony V. Moorman

https://doi.org/10.3324/haematol.2021.279177

Mutational landscape of high-grade B-cell lymphoma with MYC-, BCL2 and/or BCL6 rearrangements characterized by whole-exome sequencing (1075 Online Views)

Axel Künstner, Hanno M. Witte, Jörg Riedl, Veronica Bernard, Stephanie Stölting, Hartmut Merz, Vito Olschewski, Wolfgang Peter, Julius Ketzer, Yannik Busch, Peter Trojok, Nikolas von Bubnoff, Hauke Busch, Alfred C. Feller, Niklas Gebauer

https://doi.org/10.3324/haematol.2021.279631

Comments

Nov 11, 2021

Editorials
Article

Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy (668 Online Views)

Jana Ihlow, Sophia Gross, Leonie Busack, Anne Flörcken, Julia Jesse, Michaela Schwarz, Nina Rosa Neuendorff, Ann-Christin von Brünneck, Ioannis Anagnostopoulos, Seval Türkmen, Igor Wolfgang Blau, Thomas Burmeister, David Horst, Lars Bullinger, Jörg Westermann

https://doi.org/10.3324/haematol.2021.279134

Articles

Cardiovascular events in patients treated with chimeric antigen receptor T-cell therapy for aggressive B-cell lymphoma (1486 Online Views)

Raphael E. Steiner, Jose Banchs, Efstratios Koutroumpakis, Melody Becnel, Cristina Gutierrez, Paolo Strati, Chelsea C. Pinnix, Lei Feng, Gabriela Rondon, Catherine Claussen, Nicolas Palaskas, Kaveh Karimzad, Sairah Ahmed, Sattva S. Neelapu, Elizabeth Shpall, Michael Wang, Francisco Vega, Jason Westin, Loretta J. Nastoupil, Anita Deswal

https://doi.org/10.3324/haematol.2021.280009

Nov 4, 2021

Articles

AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia (1016 Online Views)

Sean M. Post, Huaxian Ma, Prerna Malaney, Xiaorui Zhang, Marisa J.L. Aitken, Po Yee Mak, Vivian R. Ruvolo, Tomoko Yasuhiro, Ryohei Kozaki, Lauren E. Chan, Lauren B. Ostermann, Marina Konopleva, Bing Z. Carter, Courtney DiNardo, Michael D. Andreeff, Joseph D. Khoury, Peter P. Ruvolo

https://doi.org/10.3324/haematol.2021.278369

Oct 28, 2021

Editorials
Article

Correction of RNA splicing defect in β654-thalassemia mice using CRISPR/Cas9 gene-editing technology (505 Online Views)

Dan Lu, Xiuli Gong, Yudan Fang, Xinbing Guo, Yanwen Chen, Fan Yang, Guijun Zhao, Qingwen Ma, Yitao Zeng, Fanyi Zeng

https://doi.org/10.3324/haematol.2020.278238

Articles

Ionophore-mediated swelling of erythrocytes as a therapeutic mechanism in sickle cell disease (442 Online Views)

Athena C. Geisness, Melissa Azul, Dillon Williams, Hannah Szafraniec, Daniel C. De Souza, John M. Higgins, David K. Wood

https://doi.org/10.3324/haematol.2021.278666

Genetic modifiers of fetal hemoglobin affect the course of sickle cell disease in patients treated with hydroxyurea (469 Online Views)

Pierre Allard, Nareen Alhaj, Stephan Lobitz, Holger Cario, Andreas Jarisch, Regine Grosse, Lena Oevermann, Dani Hakimeh, Laura Tagliaferri, Elisabeth Kohne, Annette Kopp-Schneider, Andreas E. Kulozik, Joachim B. Kunz

https://doi.org/10.3324/haematol.2021.278952

Oct 21, 2021

Articles

Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment (702 Online Views)

Debora Soncini, Claudia Martinuzzi, Pamela Becherini, Elisa Gelli, Samantha Ruberti, Katia Todoerti, Luca Mastracci, Paola Contini, Antonia Cagnetta, Antonella Laudisi, Fabio Guolo, Paola Minetto, Maurizio Miglino, Sara Aquino, Riccardo Varaldo, Daniele Reverberi, Matteo Formica, Mario Passalacqua, Alessio Nencioni, Antonino Neri, Mehmet K. Samur, Nikhil C. Munshi, Mariateresa Fulciniti, Roberto M. Lemoli, Michele Cea

https://doi.org/10.3324/haematol.2021.279276

Oct 14, 2021

Editorials
Letter to the Editor

Direct and indirect anti-leukemic properties of Activity-on-Target interferons for the treatment of T-cell acute lymphoblastic leukemia (537 Online Views)

Steven Goossens, Anje Cauwels, Tim Pieters, Renate De Smedt, Sara T’Sas, André Almeida, Willem Daneels, Pieter Van Vlierberghe, Jan Tavernier

https://doi.org/10.3324/haematol.2021.278913

Editorials
Article

Articles

Profound systemic alteration of the immune phenotype and an immunoglobulin switch in Erdheim–Chester disease in a single-center of 78 patients (634 Online Views)

Fleur Cohen Aubart, Lucie Poupel, Flora Saint-Charles, Frederic Charlotte, Youssef Arsafi, Eric Frisdal, Damien Roos-Weil, Jean-Francois Emile, Zahir Amoura, Maryse Guerin, Philippe Lesnik, Julien Haroche, Wilfried Le Goff

https://doi.org/10.3324/haematol.2021.279118

Isatuximab plus carfilzomib and dexamethasone versus carfilzomib and dexamethasone in relapsed multiple myeloma patients with renal impairment: IKEMA subgroup analysis (1749 Online Views)

Marcelo Capra, Thomas Martin, Philippe Moreau, Ross Baker, Ludek Pour, Chang-Ki Min, Xavier Leleu, Mohamad Mohty, Marta Reinoso Segura, Mehmet Turgut, Richard LeBlanc, Marie-Laure Risse, Laure Malinge, Sandrine Schwab, Meletios Dimopoulos

https://doi.org/10.3324/haematol.2021.279229

Oct 7, 2021

Articles

Critical role of peroxisome proliferator-activated receptor α in promoting platelet hyperreactivity and thrombosis under hyperlipidemia (813 Online Views)

Li Li, Jiawei Zhou, Shuai Wang, Lei Jiang, Xiaoyan Chen, Yangfan Zhou, Jingke Li, Jingqi Shi, Pu Liu, Zheyue Shu, Frank J. Gonzalez, Aiming Liu, Hu Hu

https://doi.org/10.3324/haematol.2021.279770

Sep 30, 2021

Editorials
Article

Utility of plasma cell-free DNA for de novo detection and quantification of clonal hematopoiesis (979 Online Views)

Fernanda Gutierrez-Rodrigues, Isabel Beerman, Emma M. Groarke, Bhavisha A. Patel, Nina Spitofsky, Laura W. Dillon, Diego Quinones Raffo, Christopher S. Hourigan, Sachiko Kajigaya, Luigi Ferrucci, Neal S. Young

https://doi.org/10.3324/haematol.2021.279230

Articles

Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients (1744 Online Views)

Jennifer R. Brown, John C. Byrd, Paolo Ghia, Jeff P. Sharman, Peter Hillmen, Deborah M. Stephens, Clare Sun, Wojciech Jurczak, John M. Pagel, Alessandra Ferrajoli, Priti Patel, Lin Tao, Nataliya Kuptsova-Clarkson, Javid Moslehi, Richard R. Furman

https://doi.org/10.3324/haematol.2021.278901

Sep 23, 2021

Articles

Retrospective analysis of pacritinib in patients with myelofibrosis and severe thrombocytopenia (1138 Online Views)

Srdan Verstovsek, Ruben Mesa, Moshe Talpaz, Jean-Jacques Kiladjian, Claire N. Harrison, Stephen T. Oh, Alessandro M. Vannucchi, Raajit Rampal, Bart L. Scott, Sarah A. Buckley, Adam R. Craig, Karisse Roman-Torres, John O. Mascarenhas

https://doi.org/10.3324/haematol.2021.279415

Sep 16, 2021

Articles

Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains in vitro and in vivo (830 Online Views)

Leo Nicolai, Rainer Kaiser, Raphael Escaig, Marie-Louise Hoffknecht, Afra Anjum, Alexander Leunig, Joachim Pircher, Andreas Ehrlich, Michael Lorenz, Hellen Ishikawa-Ankerhold, William C. Aird, Steffen Massberg, Florian Gaertner

https://doi.org/10.3324/haematol.2021.278896

Sep 9, 2021

Articles

Hepcidin regulation in Kenyan children with severe malaria and non-typhoidal Salmonella bacteremia (1630 Online Views)

Kelvin M. Abuga, John Muthii Muriuki, Sophie M. Uyoga, Kennedy Mwai, Johnstone Makale, Reagan M. Mogire, Alex W. Macharia, Shebe Mohammed, Esther Muthumbi, Salim Mwarumba, Neema Mturi, Philip Bejon, J. Anthony G. Scott, Manfred Nairz, Thomas N. Williams, Sarah H. Atkinson

https://doi.org/10.3324/haematol.2021.279316

Aug 19, 2021

Articles

Establishment of a Bernard-Soulier syndrome model in zebrafish (850 Online Views)

Qing Lin, Riyang Zhou, Panpan Meng, Liangliang Wu, Lian Yang, Wenyu Liu, Jiaye Wu, Yuhuan Cheng, Linjuan Shi, Yiyue Zhang

https://doi.org/10.3324/haematol.2021.278893

Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study (608 Online Views)

Lale Kostakoglu, Federico Mattiello, Maurizio Martelli, Laurie H. Sehn, David Belada, Chiara Ghiggi, Neil Chua, Eva González-Barca, Xiaonan Hong, Antonio Pinto, Yuankai Shi, Yoichi Tatsumi, Christopher Bolen, Andrea Knapp, Gila Sellam, Tina Nielsen, Deniz Sahin, Umberto Vitolo, Marek Trněný

https://doi.org/10.3324/haematol.2021.278663

Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease (936 Online Views)

Eileen Haring, Geoffroy Andrieux, Franziska M. Uhl, Máté Krausz, Michele Proietti, Barbara Sauer, Philipp R. Esser, Stefan F. Martin, Dietmar Pfeifer, Annette Schmitt-Graeff, Justus Duyster, Natalie Köhler, Bodo Grimbacher, Melanie Boerries, Konrad Aumann, Robert Zeiser, Petya Apostolova

https://doi.org/10.3324/haematol.2021.278387

Errata Corrige

Long-term outcomes from the phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma (1766 Online Views)

Johannes Duell, Kami J. Maddocks, Eva González-Barca, Wojciech Jurczak, Anna Marina Liberati, Sven de Vos, Zsolt Nagy, Aleš Obr, Gianluca Gaidano, Pau Abrisqueta, Nagesh Kalakonda, Marc André, Martin Dreyling, Tobias Menne, Olivier Tournilhac, Marinela Augustin, Andreas Rosenwald, Maren Dirnberger-Hertweck, Johannes Weirather, Sumeet Ambarkhane, Gilles Salles

https://doi.org/10.3324/haematol.2021.279802

Aug 12, 2021

Articles

Whole-genome profiling of primary cutaneous anaplastic large cell lymphoma (1173 Online Views)

Armando N. Bastidas Torres, Rutger C. Melchers, Liana van Grieken, Jacoba J. Out-Luiting, Hailiang Mei, Cedrick Agaser, Thomas B. Kuipers, Koen D. Quint, Rein Willemze, Maarten H. Vermeer, Cornelis P. Tensen

https://doi.org/10.3324/haematol.2020.263251

Renal function and clinical outcome of patients with cancer-associated venous thromboembolism randomized to receive apixaban or dalteparin. Results from the Caravaggio trial (853 Online Views)

Cecilia Becattini, Rupert Bauersachs, Giorgio Maraziti, Laurent Bertoletti, Alexander Cohen, Jean M. Connors, Dario Manfellotto, Antonio Sanchez, Benjamin Brenner, Giancarlo Agnelli

https://doi.org/10.3324/haematol.2021.279072

Aug 5, 2021

Articles

Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets (895 Online Views)

Inga Scheller, Sarah Beck, Vanessa Göb, Carina Gross, Raluca A. I. Neagoe, Katja Aurbach, Markus Bender, David Stegner, Zoltan Nagy, Bernhard Nieswandt

https://doi.org/10.3324/haematol.2021.278537

Jul 29, 2021

Articles

Phase I/II clinical trial of temsirolimus and lenalidomide in patients with relapsed and refractory lymphomas (1107 Online Views)

Ajay Major, Justin Kline, Theodore G. Karrison, Paul A. S. Fishkin, Amy S. Kimball, Adam M. Petrich, Sreenivasa Nattam, Krishna Rao, Bethany G. Sleckman, Kenneth Cohen, Koen van Besien, Aaron P. Rapoport, Sonali M. Smith

https://doi.org/10.3324/haematol.2021.278853

May 10, 2018

Articles

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells (717 Online Views)

Beibei Zhang, Pilar Ayuda Durán, Laure Piechaczyk, Yngvar Fløisand, Mireia Mayoral Safont Safont, Ida Tveit Karlsen, Zina Fandalyuk, Dagim Tadele, Pepijn van Mierlo, Alexander D. Rowe, Joseph M. Robertson, Bjørn Tore Gjertsen, Emmet McCormack, Jorrit M. Enserink, Bjørn Tore Gjertsen Group, Emmet McCormack Group

https://doi.org/10.3324/haematol.2018.189399